Multiple myeloma presenting as dural plasmacytoma

Gregorio, Laura M.; Soyemi, Temitope O.

doi:10.1016/j.radcr.2019.05.026

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…Recent evidence suggests that MM arises from the BM and disseminates throughout the body. Through a process that is similar to metastasis of solid tumors, the disseminated MM cells can settle at different sites including the liver, lung, brain, and other soft tissues [1][2][3]. Advanced MM may be found in up to 30% of patients and is strongly correlated with poor prognosis with an overall survival of less than 6 months [4,5].…”

Section: Introductionmentioning

confidence: 99%

O-GlcNAcylation homeostasis controlled by calcium influx channels regulates multiple myeloma dissemination

Samart

Luanpitpong

Rojanasakul

et al. 2021

J Exp Clin Cancer Res

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Background Multiple myeloma (MM) cell motility is a critical step during MM dissemination throughout the body, but how it is regulated remains largely unknown. As hypercalcemia is an important clinical feature of MM, high calcium (Ca2+) and altered Ca2+ signaling could be a key contributing factor to the pathological process. Methods Bioinformatics analyses were employed to assess the clinical significance of Ca2+ influx channels in clinical specimens of smoldering and symptomatic MM. Functional and regulatory roles of influx channels and downstream signaling in MM cell migration and invasion were conducted and experimental MM dissemination was examined in a xenograft mouse model using in vivo live imaging and engraftment analysis. Results Inhibition of TRPM7, ORAI1, and STIM1 influx channels, which are highly expressed in MM patients, and subsequent blockage of Ca2+ influx by CRISPR/Cas9 and small molecule inhibitors, effectively inhibit MM cell migration and invasion, and attenuate the experimental MM dissemination. Mechanistic studies reveal a nutrient sensor O-GlcNAcylation as a downstream regulator of Ca2+ influx that specifically targets cell adhesion molecules. Hyper-O-GlcNAcylation following the inhibition of Ca2+ influx channels induces integrin α4 and integrin β7 downregulation via ubiquitin-proteasomal degradation and represses the aggressive MM phenotype. Conclusions Our findings unveil a novel regulatory mechanism of MM cell motility via Ca2+ influx/O-GlcNAcylation axis that directly targets integrin α4 and integrin β7, providing mechanistic insights into the pathogenesis and progression of MM and demonstrating potential predictive biomarkers and therapeutic targets for advanced MM.

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Section: Introductionmentioning

confidence: 99%

O-GlcNAcylation homeostasis controlled by calcium influx channels regulates multiple myeloma dissemination

Samart

Luanpitpong

Rojanasakul

et al. 2021

J Exp Clin Cancer Res

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“…Depending on the site of infiltration at the skull base, 7 MM can first present with: (i) isolated palsies of, for example, the oculomotor, 21 abducens, 22 or hypoglossal 23 nerves; or as (ii) multiple cranial neuropathies that are either adjacent (eg, of the trigeminal and abducens nerve) 24 or separate (eg, optic neuropathy in combination with other cranial neuropathies) 25 . Even if the presenting feature is cranial, it remains important to look for concurrent neurological involvement in the spinal cord 26 or peripheral nerves, 27 which we did in our patient on clinical examination.…”

Section: Discussionmentioning

confidence: 94%

Collet‐Sicard syndrome due to concurrent extramedullary intracranial plasmacytoma and jugular venous sinus thrombosis in multiple myeloma

Sokhi¹,

Mithi²,

Ebrahim³

et al. 2021

Clinical Case Reports

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Extramedullary Intracranial Plasmacytomas: A Systematic Review of Literature

Palavani,

Bapat,

Batista

et al. 2024

Asian J Neurosurg

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Extramedullary plasmacytoma (EMP) is an uncommon disorder characterized by the development of abnormal plasma cell tumors outside the bone marrow. These tumors are typically observed in various locations, including the upper respiratory tract, gastrointestinal tract, and other soft tissues. Among the less explored manifestations of EMP is intracranial EMP, which remains poorly understood due to the limited literature available on the subject. The objective was to comprehend the population characteristics, localization, type, treatment, and outcomes of intracranial EMP. A systematic review of the literature for EMPs was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The strategy “extramedullary plasmacytoma AND multiple myeloma” was used for the search. The search terms were queried using PubMed, Embase, Scopus, Cochrane, and Web of Science databases. We included only those studies that presented clinical studies with patients diagnosed with intracranial plasmacytomas. In this study, a total of 84 patients from 25 studies were analyzed. The average age of diagnosis was 57.25 years, with a slightly higher proportion of females (57%) compared to male patients (43%). The most common locations of intracranial plasmacytomas were the clivus (29.7%), frontal lobe (18.9%), parietal lobe (8.1%), occipital lobe (6.7%), temporal lobe (6.7%), and sphenoid (4%). Chordoma and meningioma were the most common differential diagnoses encountered during clinical investigations. Treatment modalities included radiotherapy (RT), chemotherapy (QT), surgical resection (SR), and conservative approaches. The most frequent treatment combinations were SR + RT (19%) and RT only (17.8%). Mortality was reported in 48% of the cases, with complete resolution observed in 10 cases and partial resolution in 3 cases. The average follow-up duration was 37.5 months. The clivus is the most frequently reported site of extramedullary intracranial plasmacytoma (EMIP) occurrence, representing 29.7% of cases. Chordomas were commonly observed alongside EMIPs and emerged as the primary differential diagnosis. RT was the predominant treatment modality, with SR considered when feasible. RT alone demonstrated the highest effectiveness in managing EMIPs (30%), while QT as a sole intervention showed lower efficacy. However, a combination of dexamethasone, lenalidomide, and targeted RT displayed promising results, offering improved tumor response and increased safety.

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Multiple myeloma presenting as dural plasmacytoma

Cited by 4 publications

References 27 publications

O-GlcNAcylation homeostasis controlled by calcium influx channels regulates multiple myeloma dissemination

O-GlcNAcylation homeostasis controlled by calcium influx channels regulates multiple myeloma dissemination

Collet‐Sicard syndrome due to concurrent extramedullary intracranial plasmacytoma and jugular venous sinus thrombosis in multiple myeloma

Extramedullary Intracranial Plasmacytomas: A Systematic Review of Literature

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