Multiple nanoemulsions

Sheth, Tanvi; Seshadri, Serena; Prileszky, Tamás A.; Helgeson, Matthew E.

doi:10.1038/s41578-019-0161-9

Cited by 191 publications

(129 citation statements)

References 123 publications

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“…An emulsion is a colloidal system that consists of two or more entirely or partially immiscible phases where one of them was dispersed as small droplets in another phase (Komaiko, Sastrosubroto, & McClements, 2016a), and can be of the types water-in-oil (W/O), oil-in-water (O/W), or multiple-emulsions in a complex system in the form of O/W/O or W/O/W (Li et al, 2019;Sheth, Seshadri, Prileszky, & Helgeson, 2020). The emulsions can be prepared not only by surface-active substances, that is, emulsifiers, although solid nanoparticles may be used to formulate the so-called Pickering emulsions (Pickering, 1907).…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsions: Using emulsifiers from natural sources replacing synthetic ones—A review

Dammak

Sobral

Aquino

et al. 2020

Comp Rev Food Sci Food Safe

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In recent years, substantial consideration within the food industry has been aimed at the development of food‐grade nanoemulsions (NE) as promising systems for encapsulating, stabilizing, and delivering bioactive compounds. Although numerous studies have revealed the critical potential of NE, there are still several challenges to overcome them. These include the extensive amounts of synthetic emulsifiers needed for NE formulation, which can potentially be toxic for human health. The interest in safety, and natural emulsifiers have stimulated food manufacturers to develop "label‐friendly" formulations by replacing synthetic emulsifiers with natural alternatives. This review represents a critical and comprehensive summary of the application of natural emulsifiers as potential substitutes for synthetic emulsifiers in NE production, with particular emphasis on the newly identified natural emulsifiers. Some recent reports showed the excellent emulsifying properties of various natural emulsifier extracted from natural resources, to produce NE, and therefore, might be generalized for further industrial applications. Future trends are encouraged to identify novel natural emulsifiers from industrial food by‐products that may demonstrate highly effective emulsifiers.

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Section: Introductionmentioning

confidence: 99%

Nanoemulsions: Using emulsifiers from natural sources replacing synthetic ones—A review

Dammak

Sobral

Aquino

et al. 2020

Comp Rev Food Sci Food Safe

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“…In addition, formulations can be stabilized by using the proper emulsion type. In addition to conventional single emulsions (oil-in-water or water-in-oil), multiple emulsions such as water-in-oil-in-water (W/O/W) are attracting attention as a potentially more stable drug delivery system [ 30 ]. W/O/W double emulsions consist of water-in-oil emulsions dispersed in a second continuous water phase.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Lymphatic Delivery of Methotrexate Using W/O/W Nanoemulsion: In Vitro Characterization and Pharmacokinetic Study

2020

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Methotrexate, which is widely used in the treatment of cancer and immune-related diseases, has limitations in use because of its low bioavailability, short half-life, and tissue toxicity. Thus, in this study, a nano-sized water-in-oil-in-water (W/O/W) double emulsion containing methotrexate was prepared to enhance its lymphatic delivery and bioavailability. Based on the results from solubility testing and a pseudo-ternary diagram study, olive oil as the oil, Labrasol as a surfactant, and ethanol as a co-surfactant, were selected as the optimal components for the nanoemulsion. The prepared nanoemulsion was evaluated for size, zeta potential, encapsulation efficiency, pH, morphology, and in vitro release profiles. Furthermore, pharmacokinetics and lymphatic targeting efficiency were assessed after oral and intravenous administration of methotrexate-loaded nanoemulsion to rats. Mean droplet size, zeta potential, encapsulation efficiency, and pH of formulated nanoemulsion were 173.77 ± 5.76 nm, −35.63 ± 0.78 mV, 90.37 ± 0.96%, and 4.07 ± 0.03, respectively. In vitro release profile of the formulation indicated a higher dissolution and faster rate of methotrexate than that of free drug. The prepared nanoemulsion showed significant increases in maximum plasma concentration, area under the plasma concentration-time curve, half-life, oral bioavailability, and lymphatic targeting efficiency in both oral and intravenous administration. Therefore, our research proposes a methotrexate-loaded nanoemulsion as a good candidate for enhancing targeted lymphatic delivery of methotrexate.

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“…The short shelf life of the double emulsions can be enhanced by reducing the micrometer droplets size down to the nanometric scale. For this reason, many approaches have been applied to modulate the emulsion double structure and stabilize the droplets size at the nanolevel, including the nanoemulsion structural design methods [55]. These strategies involve, e.g., replacing the oil phase with a lipophilic polymer/solvent phase or using biodegradable polymers from polyester family (PLGA, PLA, PGA or PCL).…”

Section: Multiple Formulationsmentioning

confidence: 99%

“…These dispersions not only meet the requirements for easy production and scale up but also, by directly using hydrophilic and lipophilic phases at the inner or external interface. They guarantee the best possible solubilization/entrapment/encapsulation/loading efficiency of both polar and non-polar molecules [55]. The second solubilization step allows for better loading and protection from degradation as well as improved release control of the active cargo from the internal phase.…”

Section: Multiple Formulationsmentioning

confidence: 99%

“…The W/O/W type ( Figure 1 ), firstly described by Matsumoto et al (1976), is the most commonly studied system as a potential delivery formulation in the field of food ingredients, pharmaceuticals and cosmetics [ 52 , 53 ]. The significant advantage of multiple emulsions is the simultaneous introduction (entrapment/encapsulation/solubilization) of two mutually immiscible (polar and non-polar) or reactive molecules onto the internal double compartment structure and improved control release of the hybrid cargo [ 54 , 55 ].…”

Section: The Structure Of the Systemmentioning

confidence: 99%

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Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

et al. 2020

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The growing demand for effective delivery of photosensitive active compounds has resulted in the development of colloid chemistry and nanotechnology. Recently, many kinds of novel formulations with outstanding pharmaceutical potential have been investigated with an expansion in the design of a wide variety of “soft” nanostructures such as simple or multiple (double) nanoemulsions and lipid formulations. The latter can then be distinguished into vesicular, including liposomes and “smart” vesicles such as transferosomes, niosomes and ethosomes, and non-vesicular nanosystems with solid lipid nanoparticles and nanostructured lipid carriers. Encapsulation of photosensitive agents such as drugs, dyes, photosensitizers or antioxidants can be specifically formulated by the self-assembly of phospholipids or other amphiphilic compounds. They are intended to match unique pharmaceutic and cosmetic requirements and to improve their delivery to the target site via the most common, i.e., transdermal, intravenous or oral administration routes. Numerous surface modifications and functionalization of the nanostructures allow increasing their effectiveness and, consequently, may contribute to the treatment of many diseases, primarily cancer. An increasing article number is evidencing significant advances in applications of the different classes of the photosensitive agents incorporated in the ”soft” colloidal nanocarriers that deserved to be highlighted in the present review.

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Multiple nanoemulsions

Cited by 191 publications

References 123 publications

Nanoemulsions: Using emulsifiers from natural sources replacing synthetic ones—A review

Nanoemulsions: Using emulsifiers from natural sources replacing synthetic ones—A review

Enhanced Lymphatic Delivery of Methotrexate Using W/O/W Nanoemulsion: In Vitro Characterization and Pharmacokinetic Study

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

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