Multiple NMR T2 relaxation values in human liver tissue

Bernardino, ME; Small, William; Goldstein, J. H.; Sewell, CW; Pj, Sones; Gedgaudas-McClees, K; Jt, Galambos; Wenger, J; Casarella, WJ

doi:10.2214/ajr.141.6.1203

Cited by 40 publications

(12 citation statements)

References 16 publications

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“…Similar to previous NMR reports , our study demonstrates two components of the T 2 signal decay of liver tissue. However, in comparison with previous NMR reports, in which both the short and long T 2 components were typically found to be shorter than 110 ms , the long T 2 component in this study was found to approximate 400 ms. Differences in the reports may stem from differences in technique (NMR versus MRI, which introduces effects related to slice selection, etc.)…”

Section: Discussionsupporting

confidence: 91%

“…In comparing the results presented herein with previous work, several variables must be considered which may influence the T 2 spectra, including differences in the features of the raw data acquisition, such as the signal‐to‐noise ratio, data acquisition window width and sampling density, as well as features of the subsequent MET 2 processing, including the choice of data processing methodology as well as the analysis routine (region of interest versus pixel by pixel), among others . Similar to previous NMR reports , our study demonstrates two components of the T 2 signal decay of liver tissue. However, in comparison with previous NMR reports, in which both the short and long T 2 components were typically found to be shorter than 110 ms , the long T 2 component in this study was found to approximate 400 ms.…”

Section: Discussionsupporting

confidence: 79%

“…In addition to conventional monoexponential T 2 determinations, an alternative approach may be realized through further study of the T 2 relaxation properties to evaluate the presence and effects of hepatic fibrosis on the multiexponential T 2 (MET 2 ) decay of the liver. The NMR signal has been shown to exhibit MET 2 decay in various tissues, including white matter and the peripheral nervous system, skeletal muscle and liver . The use of MET 2 using MRI allows for the investigation of the microarchitecture of a tissue at the subvoxel level.…”

Section: Introductionmentioning

confidence: 99%

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Multiexponential T₂ analyses in a murine model of hepatic fibrosis at 11.7 T MRI

et al. 2012

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This study evaluated the effects of hepatic fibrosis on the multiexponential T(2) (MET(2) ) relaxation of ex vivo murine liver specimens using an 11.7 T MRI. This animal study was approved by the Institutional Animal Care and Use Committee. Eighteen male C57BL/6 mice were divided into control (n = 3) and experimental (n = 15) groups; the latter group was fed a 3,5-dicarbethoxy-1,4-dihydrocollidine-supplemented diet to induce hepatic fibrosis. Ex vivo liver specimens were imaged using an 11.7 T MRI scanner. A multi-echo spin-echo sequence was utilized for subsequent MET(2) analysis. Degrees of fibrosis were determined by a pathologist, as well as by digital image analysis. Scatterplot graphs comparing various features of the MET(2) signal decay with the degrees of fibrosis were generated, and correlation coefficients were calculated. Two distinct peaks of the MET(2) signal decay were identified in all liver specimens: a short T(2) component with a geometric mean T(2) (GMT(2) ) approximating 30 ms; and a long T(2) component with GMT(2) approximating 400 ms. Strong correlation was found between the degree of hepatic fibrosis and the amplitude of the short T(2) component, with a higher degrees of fibrosis associated with a lower amplitude. Moderate correlation was also found between hepatic fibrosis and the GMT(2) values of the long T(2) component, with higher degrees of fibrosis associated with lower GMT(2) values. The study of hepatic microenvironments using MET(2) analyses offers potential utility in the ongoing development of the noninvasive assessment of hepatic fibrosis using MRI.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

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Multiexponential T₂ analyses in a murine model of hepatic fibrosis at 11.7 T MRI

et al. 2012

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“…Tissue iron is detected indirectly by the effects on relaxation times by the interaction of ferritin and hemosiderin iron with hydrogen nuclei in normal cardiac tissue. The presence of iron in human body results in marked alteration in tissue relaxation times (15,28,29).…”

Section: Mri Principlesmentioning

confidence: 99%

MRI of cardiac iron overload

Chu

Lam³

2012

Magnetic Resonance Imaging

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Transfusion therapy has greatly improved the survival of transfusion dependent thalassemia major (TM) patients; however, the resultant iron load damages tissues including the heart, liver and endocrine organs. Among these, heart complication still remains the leading cause of mortality. Myocardial iron deposition can occur independently of other solid organ involvement; conversely, the heart may be spared despite heavy siderosis in other tissues. Iron chelation treatment diminishes the risk of hemosiderosis; however, the chelation treatment has its own toxicities and might not be available to all patients due to costs. Close monitoring of individual organ iron concentration and function is thus important for optimization of individual patient care. This review outlines the importance and clinical significance of recently available MRI techniques for monitoring cardiac iron load.

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“…28 Here we consider the spin-spin time constant, T2. Due to local differences in proton environment, relaxation processes may be multi-exponential, 29 and time, temperature and fixation all alter relaxation ex vivo. 30,31 Measurements are also affected by diffusion 32 and field strength.…”

Section: Introductionmentioning

confidence: 99%

<p>Improving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping</p>

Khuntikeo

Titapun

Chamadol

et al. 2020

HMER

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Aim: Cholangiocarcinoma is endemic in southeast Asia, generally developing from liver fluke infestation. However, diagnostic imaging of early-stage disease is challenging. The aim of this work is to investigate relaxometry (specifically, T2 mapping) as a method of exploiting the higher signal-to-noise ratio (SNR) of internal coils for improved reception of magnetic resonance signals, despite their non-uniform sensitivity. Methods: Ex vivo T2 mapping was carried out at 3T on fixed resection specimens from Thai cholangiocarcinoma patients using an mGRASE sequence and an endoscope coil based on a thin-film magneto-inductive waveguide and designed ultimately for internal use. Results: Disease-induced changes including granulomatous inflammation, intraepithelial neoplasia and intraductal tumours were correlated with histopathology, and relaxation data were compared with mono-and bi-exponential models of T2 relaxation. An approximately 10-fold local advantage in SNR compared to a 16-element torso coil was demonstrated using the endoscope coil, and improved tissue differentiation was obtained without contrast agents. Conclusion: The performance advantage above follows directly from the inverse relation between the component of the standard deviation of T2 due to thermal noise and the SNR, and offers an effective method of exploiting the SNR advantage of internal coils. No correction is required, avoiding the need for tracking, relaxing constraints on coil and slice orientation and providing rapid visualization.

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Multiple NMR T2 relaxation values in human liver tissue

Cited by 40 publications

References 16 publications

Multiexponential T₂ analyses in a murine model of hepatic fibrosis at 11.7 T MRI

Multiexponential T₂ analyses in a murine model of hepatic fibrosis at 11.7 T MRI

MRI of cardiac iron overload

<p>Improving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping</p>

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Multiple NMR T2 relaxation values in human liver tissue

Cited by 40 publications

References 16 publications

Multiexponential T2 analyses in a murine model of hepatic fibrosis at 11.7 T MRI

Multiexponential T2 analyses in a murine model of hepatic fibrosis at 11.7 T MRI

MRI of cardiac iron overload

<p>Improving the Detection of Cholangiocarcinoma: In vitro MRI-Based Study Using Local Coils and T2 Mapping</p>

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Multiexponential T₂ analyses in a murine model of hepatic fibrosis at 11.7 T MRI

Multiexponential T₂ analyses in a murine model of hepatic fibrosis at 11.7 T MRI