Multiple Novel Mosquito-Borne Zoonotic Viruses Revealed in Pangolin Virome

Zhang, Duo; Zheng, Min; Zhang, Ying; Feng, Guanrong; Peng, Chengcheng; Li, Chenghui; Li, Yiquan; Zhang, He; Li, Nan; Xiao, Pengpeng

doi:10.3389/fcimb.2022.874003

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…5e ). JEV, an arbovirus belonging to the family Flaviviridae , could accidentally infect humans 14 . JEVs detected in captive pangolins were genetically clustered in the same clade as those from bats and mosquitos in the same country (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Systematic review and integrated data analysis reveal diverse pangolin-associated microbes with infection potential

Ye,

Wang,

et al. 2023

Nat Commun

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There has been increasing global concern about the spillover transmission of pangolin-associated microbes. To assess the risk of these microbes for emergence as human pathogens, we integrated data from multiple sources to describe the distribution and spectrum of microbes harbored by pangolins. Wild and trafficked pangolins have been mainly recorded in Asia and Africa, while captive pangolins have been reported in European and North American countries. A total of 128 microbes, including 92 viruses, 25 bacteria, eight protists, and three uncharacterized microbes, have been identified in five pangolin species. Out of 128 pangolin-associated microbes, 31 (including 13 viruses, 15 bacteria, and three protists) have been reported in humans, and 54 are animal-associated viruses. The phylogenetic analysis of human-associated viruses carried by pangolins reveals that they are genetically close to those naturally circulating among human populations in the world. Pangolins harbor diverse microbes, many of which have been previously reported in humans and animals. Abundant viruses initially detected in pangolins might exhibit risks for spillover transmission.

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Section: Resultsmentioning

confidence: 99%

“…5f ). Chikungunya viruses in pangolins fell into two distinct branches 14 , one of which was clustered with those from southeastern Asia, and the other was genetically close to those from mosquitos in Senegal of western Africa (Fig. 5g ).…”

Section: Resultsmentioning

confidence: 99%

Systematic review and integrated data analysis reveal diverse pangolin-associated microbes with infection potential

Ye,

Wang,

et al. 2023

Nat Commun

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“…Similar events may also occur in the future. For example, simultaneous amplification of CHIKV and GETV has been observed in pangolins in Guangxi Province, China, indicating cotransmission of these viruses 34 . Because GETV possesses diverse receptor binding properties, it may, through coinfection and recombination events, relatively easily overcome existing host range barriers and thus represent a potential risk to public health 35 .…”

Section: The Lack Of a Distinct Receptor-binding Domain (Rbd) Has Imp...mentioning

confidence: 99%

LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy

Wang,

Merits,

Veit

et al. 2024

Nat Commun

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Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes of multiple alphaviruses to understand their ability to infect a wide range of hosts. We further discuss the challenges associated with the development of broad-spectrum treatment strategies against a diverse range of alphaviruses.

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Detection of a novel Pestivirus strain in Java ticks (Amblyomma javanense) and the hosts Malayan pangolin (Manis javanica) and Chinese pangolin (Manis pentadactyla)

Shi

Zhou

et al. 2022

Front. Microbiol.

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Pangolins are endangered animals and are listed in the CITES Appendix I of the Convention International Trade Endangered Species of Wild Fauna and Flora as well as being the national first-level protected wild animal in China. Based on a few reports on pangolins infected with pestiviruses of the Flaviviridae family, Pestivirus infections in pangolins have attracted increasing attention. Pangolin pestivirus is a pathogen that may cause diseases such as acute diarrhea and acute hemorrhagic syndrome. To better understand the epidemiology and genomic characterization of pestiviruses carried by pangolins, we detected pestiviruses in dead Malayan pangolin using metavirome sequencing technology and obtained a Pestivirus sequence of 12,333 nucleotides (named Guangdong pangolin Pestivirus, GDPV). Phylogenetic tree analysis based on the entire coding sequence, NS3 gene or RdRp gene sequences, showed that GDPV was closely related to previously reported pangolin-derived Pestivirus and clustered into a separate branch. Molecular epidemiological investigation revealed that 15 Pestivirus-positive tissues from two pangolins individuals with a positivity rate of 5.56%, and six Amblyomma javanense carried pestiviruses with a positivity rate of 19.35%. Moreover, the RdRp gene of the Pestivirus carried by A. javanense showed a high similarity to that carried by pangolins (93–100%), indicating A. javanense is likely to represent the vector of Pestivirus transmission. This study expands the diversity of viruses carried by pangolins and provides an important reference value for interrupting the transmission route of the virus and protecting the health of pangolins.

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Multiple Novel Mosquito-Borne Zoonotic Viruses Revealed in Pangolin Virome

Cited by 3 publications

References 22 publications

Systematic review and integrated data analysis reveal diverse pangolin-associated microbes with infection potential

Systematic review and integrated data analysis reveal diverse pangolin-associated microbes with infection potential

LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy

Detection of a novel Pestivirus strain in Java ticks (Amblyomma javanense) and the hosts Malayan pangolin (Manis javanica) and Chinese pangolin (Manis pentadactyla)

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