Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis

Hu, Shiqian; Rayman, Margaret P.

doi:10.1089/thy.2016.0635

Cited by 158 publications

(113 citation statements)

References 137 publications

(163 reference statements)

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…It is also possible that other nutrient deficiencies beyond iodine (e.g. selenium, iron [36,37]) interact with thyroid metabolism. Finally, thyroid size, reflected by DBS-Tg, may be larger in the Swedish population, as shown for school-aged children when compared with an age-matched reference international population [16].…”

Section: Discussionmentioning

confidence: 99%

Iodine deficiency in pregnant women in Sweden: a national cross-sectional study

et al. 2019

View full text Add to dashboard Cite

Purpose Voluntary salt iodization at 50 mg/kg salt ensures adequate iodine nutrition in Swedish school-aged children, but iodine status in pregnant women is uncertain. Methods We conducted a cross-sectional national study of 743 pregnant women, at median gestational age of 23 weeks (IQR 9, 38), recruited from maternal health care centers. We measured: urinary iodine concentration (UIC) and urinary creatinine concentration in spot urine samples; thyroglobulin (Tg), thyroid-stimulating hormone (TSH), and total thyroxine (tT4) on dried blood spots (DBS); and thyreoperoxidase antibodies in serum samples. Data on dietary supplement use were obtained, and women were classified as supplement users (consuming multivitamins containing ≥ 150 µg iodine/day) and non-supplement users (no supplements or < 150 µg iodine/day from supplements). Results Overall median UIC [bootstrapped 95% confidence interval (CI)] was 101 µg/L (95, 108; n = 737): 149 µg/L (132, 164) in supplement users (n = 253) and 85 µg/L (79, 92) in non-supplement users (n = 440) (p < 0.001). Overall geometric mean DBS-Tg (95% CI) was 22.1 μg/L (20.8, 23.5; n = 675) and the prevalence of elevated DBS-Tg was 19%. DBS-Tg was lower in supplement users (n = 229) than in non-supplement users (n = 405) (19.1 vs 24.4 μg/L, p < 0.001). DBS-TSH, DBS-tT4, and S-TPOab positivity did not differ between the two groups. Conclusions Pregnant women in Sweden have inadequate iodine nutrition. Women not taking iodine supplements containing ≥ 150 µg iodine/day are affected by mild iodine deficiency and are at higher risk for increased thyroid activity, while maintaining euthyroidism. Iodine intake should be improved in women both before and after conception by promotion of iodized salt instead of non-iodized salt. We urge regular monitoring of iodine status in the general Swedish population, as well as in risk groups.

show abstract

Section: Discussionmentioning

confidence: 99%

Iodine deficiency in pregnant women in Sweden: a national cross-sectional study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Fontos megjegyezni, hogy a szelénnel kezelt betegek savójá-ban nemcsak az anti-TPO-titer csökkenése volt feltűnő, hanem a keringő komplexek eltűnése is. Ez a jelenség a szelénnek az autoimmun mechanizmusra és a pajzsmirigy működésre kifejtett hatásaival állhat összefüggés-ben [17,18]. A makro-TSH kialakulásának okát nem tudjuk, de közelebb vihetnek a jelenség megértéséhez a TSH molekuláira vonatkozó újabb adatok.…”

Section: Megbeszélésunclassified

A makro-TSH diagnosztikus és terápiás jelentősége Hashimoto-thyreoiditises betegekben

Balázs

Rácz

2017

Orvosi Hetilap

View full text Add to dashboard Cite

Bevezetés: A makro-TSH szerkezete, incidenciája és klinikai szerepe pajzsmirigybetegekben nem tisztázott. Célkitűzés: A makro-TSH előfordulási gyakoriságának, tulajdonságainak meghatározása Hashimoto-thyreoiditises betegek savójában. Módszer: A Hashimoto-thyreoiditises betegek vérmintáiban a makro-TSH-t meghatározták polietilén-glikol precipitációs módszerrel és protein G agaróz abszorpciós, illetve gélfiltrációs kromatográfiával. A makro-TSH biológiai aktivitását TSH-receptorral transzfektált CHO bioassay módszerével mérték. A betegek L-tiroxin-kezelésben részesül-tek (átlagosan 66,5 µg/nap), a betegek fele pedig szelént is kapott (átlagosan 60 µg/nap). Eredmények: 880 Hashimoto-thyreoiditises beteget (728 nő, átlagéletkor 44,8 év) vontak be a vizsgálatba. A makro-TSH-t 41 betegben (4,6%) mutatták ki, az átlagos TSH-szint a PEG-precipitáció előtt 185,4 ± 35 IU/l volt, a precipitáció után pedig 5,55 ± 1,8 IU/l. Az anti-TPO-szint 445 ± 51 IU/l volt és fokozatosan csökkent 212 ± 51 IU/l-re egyéves tiroxin-és szelénkezelés után. Mind a PEG-precipitációs, mind a protein G abszorpciós módszerrel, illetve gélkromatográfiás eljárással a TSH elleni antitest jelenlétét mutatták ki a makro-TSH-immunkomplexben. A makro-TSH biológialag inaktívnak bizonyult, mivel a CHO-sejteket nem stimulálta. A makro-TSH a szelénnel nem kezelt csoportban 18 ± 3,2 hónapig, a szelénnel kezeltben 12 ± 1,9 hónapig volt kimutatható. Következtetés: A TSH elleni antitestek fő komponensei a makro-TSH-nak és diagnosztikus, illetve terápiás nehézsége-ket okozhatnak. A PEG-precipitációs eljárás alkalmas szűrőmódszer a makro-TSH bizonyítására. A szelén képes nemcsak az anti-TPO-, hanem a makro-TSH-szint csökkentésére egyaránt. Amikor a TSH-szint 40,0 IU/l feletti a hypothyreosis jelei nélkül, gondolnunk kell a makro-TSH jelenlétére. Orv Hetil. 2017; 158(34): 1346-1350. Kulcsszavak: TSH, makro-TSH, Hashimoto-thyreoiditis, anti-TPO, hypothyreosis Diagnostic and therapeutical significance of macro-TSH in patients with Hashimoto's thyroiditisIntroduction: Structure, importance and incidence and clinical role of macro-TSH not clarified in thyroid diseases. Aim: This study was undertaken to determine the incidence and biological role of macro-TSH in patients with Hashimoto's thyroiditis. Method: Blood samples taken from patients with Hashimoto's thyroiditis were screened for the presence of macro-TSH with the polyethylene glycol method and confirmed with protein G agarose absorption test and gel filtration chromatography. Stimulatory capacity of macro-TSH was measured by CHO cells bio-assay. Patients were treated with L-thyroxine (mean 66.5 µg/day) and half of them with selenium (mean 60 µg/day), respectively. Results: 880 patients (728 female, aged 44.8 yr) with Hashimoto's thyroiditis was involved in the study. Macro-TSH was found in the serum of 41 patients (4.6%), the mean TSH 185.4 ± 35 IU/l was before PEG precipitations and after 5.55 ± 1.8 IU/l. Titre of anti-TPO proved to be 445 ± 51 IU/l and gradulally decreased to 212 ± 51 IU/l after one year ther...

show abstract

“…Chronic lymphocytic thyroiditis (Hashimoto's thyroiditis -HT) is one of the most prevalent autoimmune diseases worldwide. Women are 5-10 times more likely to have HT compared to men, predominantly between the ages of 30 and 50 years [16][17][18][19]. The disease is due to an autoimmune attack on the thyroid gland by autoreactive lymphocytes and autoantibodies against thyroid peroxidase (anti-TPO) and thyroglobulin (anti-TG).…”

Section: Introductionmentioning

confidence: 99%

“…Przewlekłe limfocytarne zapalenie tarczycy, czyli choroba Hashimoto jest jedną z najczęściej występujących chorób autoimmunologicznych na świecie. Chorobę rozpoznaje się 5-10-krotnie częściej u kobiet niż u mężczyzn, najczęściej w 4.-5. dekadzie życia [16][17][18][19]. U podłoża schorzenia leżą mechanizmy podlegające na atakowaniu tkanek własnych tarczycy poprzez autoreaktywne limfocyty, jak również autoprzeciwciała przeciwko peroksydazie tarczycowej (anty-TPO) oraz tyreoglobulinie (anty-TG).…”

Section: Introductionunclassified

Can Hashimoto's thyroiditis cause vertigo? [Czy choroba Hashimoto może być przyczyną zawrotów głowy?]

Miśkiewicz-Orczyk

Lisowska

Kajdaniuk

et al. 2020

Endokrynologia Polska

View full text Add to dashboard Cite

Vertigo and balance disorders are common symptoms reported by approximately 15-20% of the adult population worldwide. For many years thyroid diseases have been suspected as the cause of vertigo by ENT physicians. Almost every patient hospitalised due to severe vertigo is investigated for thyroid disease as a suspected cause of acute vestibulopathy. The issue presented in this paper is related to a difficult and poorly understood relationship between autoimmune thyroid disease and peripheral vertigo. (Endokrynol Pol 2020; 71 (1): 76-81) Artykuł jest tłumaczeniem pracy: Katarzyna A. Miśkiewicz-Orczyk, Grażyna Lisowska, Dariusz Kajdaniuk, Mateusz Wojtulek. Can Hashimoto's thyroiditis cause vertigo? Endokrynol Pol 2020; 71 (1): 76-81. Należy cytować wersję pierwotną. Piśmiennictwo dostępne w wersji pierwotnej na stronach 79-81. Endokrynologia Polska Volume/Tom 71; Number/Numer 1/2020

show abstract

Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis

Cited by 158 publications

References 137 publications

Iodine deficiency in pregnant women in Sweden: a national cross-sectional study

Iodine deficiency in pregnant women in Sweden: a national cross-sectional study

A makro-TSH diagnosztikus és terápiás jelentősége Hashimoto-thyreoiditises betegekben

Can Hashimoto's thyroiditis cause vertigo? [Czy choroba Hashimoto może być przyczyną zawrotów głowy?]

Contact Info

Product

Resources

About