Multiple Object Tracking While Walking: Similarities and Differences Between Young, Young-Old, and Old-Old Adults

Kristell, Pothier; Benguigui, Nicolas; Kulpa, Richard; Chavoix, Chantal

doi:10.1093/geronb/gbu047

Cited by 32 publications

(35 citation statements)

References 35 publications

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“…Polypharmacy also impairs cognition (Langeard et al, 2016;Rawle et al, 2018). Yet, association between low cognitive abilities and increased risk of falling is well-known (Herman et al, 2010;Montero-Odasso et al, 2012;Li et al, 2018), which is consistent with the high interference of cognitive demands with postural control, widely demonstrated in both young and older adults (Lundin-Olsson et al, 1997), and even more so in old-old adults (Pothier et al, 2015). Among the cognitive abilities, executive function would be preferentially involved in falls (Herman et al, 2010;Segev-Jacubovski et al, 2011;Hsu et al, 2012).…”

Section: Introductionmentioning

confidence: 71%

Psychotropic Polypharmacy in Adults 55 Years or Older: A Risk for Impaired Global Cognition, Executive Function, and Mobility

et al. 2020

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Objectives: With their broad spectrum of action, psychotropic drugs are among the most common medications prescribed to the elderly. Consequently, the number of older adults taking multiple psychotropic drugs has more than doubled over the last decade. To improve knowledge about the deleterious effects of psychotropic polypharmacy, we investigated whether there is a threshold number of psychotropic molecules that could lead to impairment of global cognition, executive function, or mobility. Furthermore, relationships between the number of psychotropic molecules and cognitive and mobility impairment were examined. Design: Cross-sectional studySetting: University Hospital of Caen (France) and advertisements in medical offices Participants: Community-dwelling older adults 55 years and older (n = 177; 69.8 ± 9.3 years; 81% women) Measurements: Number of psychotropic molecules taken daily, global cognition assessed with the Mini Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA), processing speed with the Trail Making Test (TMT) A, executive function with the TMT B and TMT B-A, and mobility with the Time Up and Go (TUG). The threshold numbers of psychotropic molecules were determined by ROC curves analysis. Based on these threshold values, multinomial logistic regression adjusting for covariates was then performed.Results: Logistic regressions showed that the threshold of two daily psychotropic molecules, identified by the ROC curves analysis, increases the risk of impaired executive function (p = .05 and.005 for the TMT B and TMT B-A, respectively), global cognition (p = .006 and.001 for the MMSE and MoCA, respectively), and mobility (p = .005 for the TUG), independent of confounding factors, including comorbidities. Furthermore, psychotropic polypharmacy would affect mobility through executive functions.Conclusion: Impairment of global cognition, executive function, and mobility when as few as two psychotropic molecules are consumed in relatively healthy young older adults should alert physicians when prescribing combinations of psychotropic medications.

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Section: Introductionmentioning

confidence: 71%

Psychotropic Polypharmacy in Adults 55 Years or Older: A Risk for Impaired Global Cognition, Executive Function, and Mobility

et al. 2020

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“…Only rare studies have addressed the issue of the risks of falling (Ziere et al, 2006; Bennett et al, 2014), mobility impairments, in particular during dual walking task (Pothier et al, 2014) or polypharmacy (Bennett et al, 2014; Lu et al, 2015) at different stages of life in older adults. Further investigations would thus be useful for improving our understanding of the deleterious effects of polypharmacy at different stages of adult life in order to implement accurate strategies as soon as polypharmacy becomes a risk to people.…”

Section: Discussionmentioning

confidence: 99%

Polypharmacy Cut-Off for Gait and Cognitive Impairments

et al. 2016

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Background: Polypharmacy is a well-established risk factor for falls, and these are one of the major health problems that affect the quality of life as people age. However, the risk of mobility and cognitive impairments consecutive to polypharmacy has been little addressed, despite the association between these adverse outcomes and falls. Moreover, the rare polypharmacy cut-offs were all but one arbitrarily determined.Objective: Studying relationships between polypharmacy and both mobility and cognitive impairments, and statistically determining a cut-off point in the number of medicinal molecule beyond which polypharmacy has deleterious consequences with respect to mobility and cognitive impairment.Methods: We enrolled 113 community-dwelling adults aged 55 years and older with a fall history, with or without injury, in the previous year. We carefully collected information about daily medicinal molecules taken. We assessed basic mobility and global cognition with the Time-Up-and-Go and the Montreal Cognitive Assessment (MoCA) test, respectively (clinicaltrials.gov NCT02292316).Results: Timed-Up and Go test and MoCA scores were both significantly correlated with the number of molecule, used. Receiver Operating Characteristic curves indicate, with high prediction (p < 0.002), that daily consumption of five or more molecules is associated with risk for both impaired mobility and global cognition. These relationships were independent of the number of comorbidities and of the pharmacological class.Conclusion: Community-dwelling adults aged 55 years and older who take five or more daily medicinal molecules are at high risk for both mobility and cognitive impairments. Physicians and patients should be aware of these new findings, especially when there are multiple prescribers involved in the care of the patient.

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“…Potentially, confounding factors were age, sex, residential area, Charlson comorbidity index, chronic disease, and disability. The sample was divided into young‐old (aged 60‐74 years) and old‐old (aged 75 years and older) groups based on previous studies . The residential area was classified based on the administrative district (seven metropolitan cities and nine provinces); that is, a residential area was classified as “urban” for the metropolitan cities and “rural” for the nine provinces.…”

Section: Methodsmentioning

confidence: 99%

Poverty and suicide risk in older adults: A retrospective longitudinal cohort study

Choi

Kim

Shin

et al. 2019

Int J Geriat Psychiatry

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Objectives The present study evaluated suicide risk within 1 year after discharge among older adults with stroke as a function of depression onset. Method We used the Korean National Health Insurance Service‐Senior cohort data and included first discharged patients with a stroke as the principal diagnosis. The comparison group was selected by a 1:2 case‐control propensity score matching for age, sex, Charlson comorbidity index, and diagnosis year between 2005 and 2012. Suicide deaths were measured by code for causes of death from Statistics Korea, and the main outcome was suicide death within 1 year following discharge. An adjusted hazard ratio (AHR) of suicidal risk was measured using a Cox proportional hazard model. Results In the total sample of 128 286 older adults (aged 63‐114 years), the higher suicidal risk was examined for stroke patients vs the comparison group (AHR = 1.4; 95% confidence interval [CI], 1.1‐1.8). Stroke patients with depression had an increased suicide risk (AHR = 2.9; 95% CI, 1.8‐4.8) but only for poststroke depression (AHR = 4.1; 95% CI, 1.8‐9.5). Pre and poststroke depression suicidality (AHR = 4.8; 95% CI, 2.1‐11.1) was also higher when compared to stroke patients without depression. Conclusions Poststroke patients are at increased suicidal risk during 1 year following discharge. Furthermore, patients who were diagnosed with depression after a stroke are more likely to commit suicide than stroke patients without depression. This suggests a necessity for early suicide preventive intervention for stroke patients while considering depressive symptomology.

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Multiple Object Tracking While Walking: Similarities and Differences Between Young, Young-Old, and Old-Old Adults

Abstract: These different profiles between the two groups of older participants could be explained in terms of compensation strategies and risk of falling.

Cited by 32 publications

References 35 publications

Psychotropic Polypharmacy in Adults 55 Years or Older: A Risk for Impaired Global Cognition, Executive Function, and Mobility

Psychotropic Polypharmacy in Adults 55 Years or Older: A Risk for Impaired Global Cognition, Executive Function, and Mobility

Polypharmacy Cut-Off for Gait and Cognitive Impairments

Poverty and suicide risk in older adults: A retrospective longitudinal cohort study

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