“…This assumption is often not met in clinical conditions. Participant factors including employment flexibility, socioeconomic status, transportation availability, and even underlying physical, mental, or emotional health may affect the ability a participant to receive planned therapy [ [23] , [24] , [25] , [26] , [27] ]. When the aWLC method is applied in clinical situations, we expect the Stage I durations for the control group will be both more variable and longer than the current simulation study implies.…”