Multiple organ dysfunction syndrome and death secondary to Cyberlindnera fabianii

Desai, Mehul; Nitta, Bradley; Dhanani, Hussain; Djurkovic, Svetolik; Katugaha, Shalika B.

doi:10.1016/j.mmcr.2019.07.004

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…However, recently, few case reports have highlighted its pathogenic activity in high-risk patients, thus recognizing that fungus is an emerging pathogen associated with fungaemia, sepsis, and multiple organ dysfunction syndrome. Interestingly, half of reported cases occurred in pediatric patients, while an outbreak of fungaemia involving preterm neonates has also been reported [ 42 , 43 ]. Although data on antifungal susceptibility of C. fabianii are limited, it appears that fluconazole, itraconazole, and posaconazole are less active compared to voriconazole, 5-flucytosine, and echinocandins [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Rare Invasive Yeast Infections in Greek Neonates and Children, a Retrospective 12-Year Study

Noni

Stathi

Velegraki

et al. 2020

JoF

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Although Candida species remain the leading cause of invasive fungal infections (IFI), the list of other isolated fungal pathogens is increasing. The aim of the study was to report cases of IFI caused by rare yeasts in the largest tertiary Greek pediatric hospital. A retrospective study was performed from 6/2008–6/2020 regarding IFI caused by rare species. Identification of isolates was attained by conventional, molecular, and MALDI TOF MS methods, and susceptibility testing was performed according to the Clinical and Laboratory Standards (CLSI) methodology. During a 12-year period, 14 different rare fungal species in 33 neonates and children with IFI hospitalized in intensive care and oncology units were isolated from blood, central catheters, peritoneal, pleural, or pericardial fluid specimens. It is the first time for IFI caused by Wickerhamomyces anomalus (Candida pelliculosa), Pichia fermentans (Candida lambica), Yarrowia (Candida) lipolytica, Pichia (Hansenula) kluyveri, Rhodotorula mucilaginosa, Wickerhamiella (Candida) pararugosa and Cyberlindnera (Candida) fabianii in Greek neonates and children to be reported. For most of these rare fungal species isolated in the present study, no official antifungal breakpoints have been defined, and there are no guidelines for their treatment. Clinical laboratories should be aware of uncommon and emerging yeast pathogens and be able to detect them with molecular and proteomic methods.

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Section: Discussionmentioning

confidence: 99%

Rare Invasive Yeast Infections in Greek Neonates and Children, a Retrospective 12-Year Study

Noni

Stathi

Velegraki

et al. 2020

JoF

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“…It has been described under the genus Hansenula, Pichia and Lindnera [270], and next as Cyberlindnera along with 20 other taxa since the genus Lindnera was a later homonym of an already published genus Lindnera in 1866 [271]. C. fabianii rarely been reported as a human pathogen, but due to advanced diagnostic methods and therapeutic techniques, infection has been increasingly recognised [272][273][274][275][276][277][278][279][280][281][282][283][284][285][286][287][288]. One Flo11-type adhesin that contains two Flo11 domains in the N-terminal region, was found in the Pfam database (Table 3).…”

Section: Candida Species That Rarely Cause Infectionsmentioning

confidence: 99%

The Flo Adhesin Family

2021

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The first step in the infection of fungal pathogens in humans is the adhesion of the pathogen to host tissue cells or abiotic surfaces such as catheters and implants. One of the main players involved in this are the expressed cell wall adhesins. Here, we review the Flo adhesin family and their involvement in the adhesion of these yeasts during human infections. Firstly, we redefined the Flo adhesin family based on the domain architectures that are present in the Flo adhesins and their functions, and set up a new classification of Flo adhesins. Next, the structure, function, and adhesion mechanisms of the Flo adhesins whose structure has been solved are discussed in detail. Finally, we identified from Pfam database datamining yeasts that could express Flo adhesins and are encountered in human infections and their adhesin architectures. These yeasts are discussed in relation to their adhesion characteristics and involvement in infections.

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“…In addition, hospital outbreaks have been also reported in pre-term newborns, suggesting the emergence of nosocomial transmission [ 6 ]. The number of described predisposing factors is scarce, but severe immunosuppression, low birth weight and surgical intervention may contribute to the infection [ 7 ]. It is noteworthy that the usage of indwelling catheters is one of the most important sources of infections, further emphasising the role of biofilm development in Cy.…”

Section: Introductionmentioning

confidence: 99%

“…It is noteworthy that the usage of indwelling catheters is one of the most important sources of infections, further emphasising the role of biofilm development in Cy. fabianii- related cases [ 1 , 7 ]. The optimal therapeutic strategy against Cy.…”

Section: Introductionmentioning

confidence: 99%

The In Vitro Activity of Fluconazole, Amphotericin B and Echinocandins Against Cyberlindnera fabianii Planktonic Cells and Biofilms

et al. 2022

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Until recently, little was known about the susceptibility pattern of Cyberlindnera fabianii (Cy. fabianii) planktonic cells and biofilms regarding the most frequently administered systemic antifungals, despite the high mortality rate and its potential role in catheter-related infections. In the current study, the activity of fluconazole, amphotericin B and echinocandins (anidulafungin, caspofungin and micafungin) was determined against planktonic and sessile cells of Cy. fabianii clinical isolates (n = 8). Planktonic minimum inhibitory concentrations (MICs) ranged from 1 to 2, from 0.25 to 1, from 0.015 to 0.06, from 0.03 to 0.12 and from 0.25 to 0.5 mg/l for fluconazole, amphotericin B, anidulafungin, caspofungin and micafungin, respectively. One-day-old biofilms were highly resistant to fluconazole (MIC ranged from 512 to > 512) compared to planktonic counterparts, but not to amphotericin B (MIC ranged from 0.25 to 2 mg/l) and echinocandins (MIC ranged from 0.06 to 2 mg/l). Based on the calculated planktonic killing rates, the highest activity was observed in the case of anidulafungin (k values ranged from 0.37 to 2.09), while micafungin, caspofungin, amphotericin B and fluconazole exerted 0.46–1.47, 0.14–0.86, −0.03 to 2.08 and −0.15 to 0.09 killing rate value ranges, respectively. The obtained in vitro planktonic and sessile susceptibility patterns suggest that echinocandins and amphotericin B may be the most reliable treatment option for the treatment of Cy. fabianii infections.

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Multiple organ dysfunction syndrome and death secondary to Cyberlindnera fabianii

Cited by 6 publications

References 23 publications

Rare Invasive Yeast Infections in Greek Neonates and Children, a Retrospective 12-Year Study

Rare Invasive Yeast Infections in Greek Neonates and Children, a Retrospective 12-Year Study

The Flo Adhesin Family

The In Vitro Activity of Fluconazole, Amphotericin B and Echinocandins Against Cyberlindnera fabianii Planktonic Cells and Biofilms

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