Multiple osteolytic bone and lung metastases from prostate cancer including small cell carcinoma with marked increases in CEA and Pro-GRP

Okamura, Shun; Fujiwara, Yu; Nagata, Kaoru

doi:10.1016/j.eucr.2019.100883

Cited by 1 publication

(1 citation statement)

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“…Although serum tumour markers have some value in cancer diagnosis, pathological staging, and prognostic assessment, there are various serum tumour markers that can be used for lung cancer screening, the most commonly used ones include CEA and NSE [ 34 ]. NSE is an enzyme marker that is specific for central nervous cells and endocrine tissues and has high serum levels in neuroendocrine diseases (e.g., small-cell carcinoma of the lung) and adenocarcinoma [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Detection of Changes in CEA and ProGRP Levels in BALF of Patients with Peripheral Lung Cancer and the Relationship with CT Signs

Huang

Ren

2023

Contrast Media & Molecular Imaging

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Objective. To investigate the relationship between the detection of changes in the levels of carcinoembryonic antigen (CEA) and progastrin-releasing peptide (ProGRP) in bronchoalveolar lavage fluid (BALF) and CT signs in patients with peripheral lung cancer. Methods. Retrospective analysis of 108 patients with perihilar lung cancer who attended our hospital from January 2019 to January 2022, 54 cases were randomly selected as the observation group and 50 cases as the control group. Patients in both groups received CT examination and BALF test at the same time to observe and compare the differences in serum levels, the relationship between CT signs and serum indices, and the diagnostic value of peripheral lung cancer between the two groups. Results. The serum levels of ProGrp, CEA, CA211, and NSE in the observation group were significantly higher than those in the control group, and the difference was statistically significant ( P < 0.05). The morphology, density, mass enhancement pattern, bronchial morphology, obstructive signs, and lymph node fusion of CT signs were compared between the observation group and the control group, indicating that CT signs were more helpful for the localization, diagnosis, and staging of lung cancer. The results of ROC curve analysis showed that the AUC value of low-dose CT combined with serum ProGrp, CEA, CA211, and NSE was 0.892, sensitivity was 96.21%, and specificity of 90.05%, which were significantly higher than those of the single tests, respectively. The positive likelihood ratio was 84.41% and the negative likelihood ratio was 87.11%. Conclusion. The combination of CT signs and serum tumour markers helps to improve the detection rate, sensitivity, and specificity of lung cancer, which has a high diagnostic rate for lung cancer and may provide evidence for the early diagnosis of lung cancer.

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Section: Discussionmentioning

confidence: 99%