Multiple papillomatosis of the lower respiratory tract. Clinical and pathologic study of eleven cases

Abstract

Eleven cases of multiple papillomatosis of the lower respiratory tract are reported and the clinicopathologic picture is studied. These cases include some extremely rare varieties and a 44‐year follow‐up. When the disease starts during childhood, it usually appears to be self‐limiting if properly managed. In adults, however, the disease sometimes runs a more protracted course with a higher risk of developing cancer. This study illustrates the difficulties of management and diagnosis and establishes the disease as a definite clinicopathologic entity.

Lung involvement in juvenile onset recurrent respiratory papillomatosis: A systematic review of the literature

“…Seventytwo publications were case reports, with four having more than one case [87][88][89][90], for a total of 76 cases including our unpublished case [14]. The five case series [3,6,7,91,92] yielded 19 patients with pulmonary involvement, while the 23 cohort studies [5,17, yielded 55 patients with lung involvement. Finally, the experimental studies added 11 patients.…”

An Adult Case of Multiple Squamous Papillomas of the Trachea Associated with Human Papilloma Virus Type 6

“…geal papillomas which spread into the inferior airways or tracheobronchial papillomas without laryngeal involvement have been men with a high incidence of malignant transformation (8)(9)(10). (2).…”

“…First, this is an elderly woman case of multiple papillomas localized to the trachea without laryngeal involvement; such findings have been reported predominantly in adult man cases (8)(9)(10) …”

Non–Small Cell Carcinomas of the Lung

“…These lesions will show squamous epithelium with some evidence of maturation remaining and in focal areas may demonstrate areas of transition between squamous and nonsquamous epithelium. [20][21][22] Cystic The cystic variant usually is recognized from the gross appearance of the tumor. It is characterized by prominent cystically dilated spaces, which may be filled with necrotic or inflammatory debris.…”