Multiple pathways are responsible for Anti-inflammatory and Cardiovascular activities of Hordeum vulgare L.

Gul, Saima; Ahmed, Sagheer; Kifli, Nurolaini; Uddin, Qazi Tahir; Tahir, Nafisa Batool; Hussain, Abrar; Jaafar, Hawa Z. E.; Moga, Marius; Zia-Ul-Haq, Muhammad

doi:10.1186/s12967-014-0316-9

Cited by 34 publications

(35 citation statements)

References 34 publications

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“…Plants are important in finding cure for various human ailments. Inhibition of AA metabolites by natural compounds has previously been reported [33]. Many medicinal plants and their secondary metabolites inhibit both enzymatic pathways of AA, resulting in the simultaneous inhibition of LOX and COX-mediated products [34].…”

Section: Discussionmentioning

confidence: 99%

Antiplatelet and Antioxidant Activities of Tomato

Khan¹,

Iqbal²,

Ahmed³

et al. 2019

JFNR

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Tomato, botanically known as Lycopersicon esculentum, is a food crop used throughout world in different cultures. Traditionally, various cardiovascular and inflammatory ailments are cured by fruit of this plant. But this has been done without any knowledge about its exact mechanism in these diseases, especially in thrombotic conditions. This study has been designed to investigate the potential mechanisms used by Lycopersicon esculentum fruit to provide relief in these diseases. A crude fraction of Lycopersicon esculentum fruits was prepared and then separated into n-hexane, chloroform and aqueous fractions. These fractions were screened for the presence of activities against arachidonic acid (AA) metabolism and agonist-induced human platelet aggregation. These fractions were also investigated for their potential to enhance the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx). Platelet aggregation was monitored using turbidometric principle, while AA metabolism was studied using radiolabelled AA. Antioxidant enzymes were measured by commercial kits using spectrophotometer. The aqueous fraction of Lycopersicon esculentum was mostly active against cyclooxygenase pathway of AA metabolism while chloroform was the only fraction possessing significant activity against lipoxygenase pathway. Aqueous and n-hexane fraction seem to have concentrated compounds responsible for elevating SOD activity while n-hexane was the most potent against PAF and the only fraction exhibiting potent activity against collagen-induced platelet aggregation. Compounds responsible for elevating GPx activity seems to be distributed throughout various fractions of tomato. The results demonstrate that anti-inflammatory and cardiovascular effects of Lycopersicon esculentum are mediated through multiple pathways. The compounds responsible for these pharmacological actions were however, distributed throughout various fractions of Lycopersicon esculentum.

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Section: Discussionmentioning

confidence: 99%

Antiplatelet and Antioxidant Activities of Tomato

Khan¹,

Iqbal²,

Ahmed³

et al. 2019

JFNR

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“…Yava (Hordeum vulgare) Inhibits platelet aggregation, anti-inflammatory, useful in cardiovascular diseases, protects against diabetes, obesity, atherosclerosis and stroke, improves insulin resistance, antioxidant [36] Shyamaka (Setaria italica) Antidiabetic [37] Kodrava (Paspalum scrobiculatum Linn. )…”

Section: Dietmentioning

confidence: 99%

Untitled

Mamidi

2017

IJGP

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Urustambha is a grave condition, in which the patient's thighs become painful, numb and immobile. Urustambha is a disease which is not amenable to panchakarma (five evacuative procedures) treatment. Till date, there is no clear understanding of the concept of Urustambha and its clinical application. This article is aimed to understand the concept of Urustambha and its correlation with relevant modern pathology or disease. Urustambha is a lifestyle disease and it is commonly seen in higher socioeconomic status. Urustambha samprapti resembles with atherogenesis. Diva swapna and raatri jaagarana explained in Urustambha nidaana may indicate obstructive sleep apnea (OSA). Clinical presentation of Urustambha may be unilateral or bilateral or both. Charaka's version of Urustambha indicates vascular pathology like "aortoiliac occlusion" with an underlying "metabolic syndrome (MS)," whereas Sushruta's version of Urustambha indicates inflammatory pathology of spinal cord like "acute transverse myelitis" or "inflammatory myelopathy" or "infectious myelitis." Principles of Urustambha are applicable for the prevention and management of the conditions like atherosclerosis, MS, OSA, aortoiliac occlusion, diabetes mellitus, obesity, cardiovascular pathology, acute myelopathy and other ischemic and inflammatory spinal diseases.

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“…(annual baby's breath) Caryophyllaceae gypsophilin China, India Used for the treatment of immune disorders, liver diseases Not indicated [70] Hordeum vulgare L. (barley) Poaceae JIP60, barley toxins China, India, Japan, Korea Used for the treatment of cardiovascular diseases, diabetes, hyperuricemia, urinary stones Seeds [23,54,71] Ancient Egypt Used as astringent and for the treatment of skin irritation Seeds [37][38][39] Mediterranean area Used as tonic Used for the treatment of gastric ulcers, gynaecological disorders Seeds [21,35,36] Hura crepitans L. (sandbox tree) Euphorbiaceae H. crepitans RIPs, crepitin, hurin South America Used as antidote for snakebites, emetic, purgative Used for the treatment of elephantiasis, leprosy, rheumatism, toothache Bark, latex, seeds [72] Peru Used as anti-oxidant, tonic Used for the treatment of amenorrhea, dysentery, dysmenorrhea, flu, obesity, oliguria Seeds [18,154] Some of the type 2 RIPs are highly toxic and for this reason have been recognized since ancient times by traditional healers, starting from Ricinus communis L. (castor bean), which produces ricin, the best known RIP and also one of the oldest known RIPs. A list of RIP-expressing plants, traditionally identified as medicinal plants for their pharmacological properties, is given in Table 1.…”

Section: Chinamentioning

confidence: 99%

Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine

et al. 2016

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Ribosome-inactivating proteins (RIPs) are enzymes that deadenylate nucleic acids and are broadly distributed in the plant kingdom. Many plants that contain RIPs are listed in the pharmacopoeias of folk medicine all over the world, mostly because of their toxicity. This review analyses the position occupied in traditional medicine by plants from which RIPs have been isolated. The overview starts from the antique age of the Mediterranean area with ancient Egypt, followed by the Greek and Roman classic period. Then, the ancient oriental civilizations of China and India are evaluated. More recently, Unani medicine and European folk medicine are examined. Finally, the African and American folk medicines are taken into consideration. In conclusion, a list of RIP-expressing plants, which have been used in folk medicine, is provided with the geographical distribution and the prescriptions that are recommended by traditional healers. Some final considerations are provided on the present utilization of such herbal treatments, both in developing and developed countries, often in the absence of scientific validation. The most promising prospect for the medicinal use of RIP-expressing plants is the conjugation of purified RIPs to antibodies that recognise tumour antigens for cancer therapy.

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Multiple pathways are responsible for Anti-inflammatory and Cardiovascular activities of Hordeum vulgare L.

Cited by 34 publications

References 34 publications

Antiplatelet and Antioxidant Activities of Tomato

Antiplatelet and Antioxidant Activities of Tomato

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Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine

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