Multiple-phase helical CT of the liver for detecting small hepatomas in patients with liver cirrhosis: contrast-injection protocol and optimal timing.

Mitsuzaki, Katsuhiko; Yamashita, Yasuyuki; Ogata, Ichiro; Nishiharu, Taiji; Urata, Joji; Takahashi, Manabu

doi:10.2214/ajr.167.3.8751695

Cited by 152 publications

(94 citation statements)

References 5 publications

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“…As in other studies [3,4,13,14], a lesion-by-lesion pathologic evaluation was not performed. These patients are often on proto cols that require frequent CT examinations.…”

Section: Ajr:171 September 1998mentioning

confidence: 99%

Using triphasic helical CT to detect focal hepatic lesions in patients with neoplasms.

Miller

Butler²,

Hoff³

et al. 1998

American Journal of Roentgenology

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“…As in other studies [3,4,13,14], a lesion-by-lesion pathologic evaluation was not performed. These patients are often on proto cols that require frequent CT examinations.…”

Section: Ajr:171 September 1998mentioning

confidence: 99%

Using triphasic helical CT to detect focal hepatic lesions in patients with neoplasms.

Miller

Butler²,

Hoff³

et al. 1998

American Journal of Roentgenology

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“…In intravenous contrast-enhanced CT, the enhancing effect is reported to be determined by the technique 2,[5][6][7]9,11,12,14) of the administration of the contrast medium, including the infusion rate, infusion method, infusion volume, and the time of the beginning of scanning (delay time), and physiologic factors 2,8,10,15) in the patient such as the age, body weight, hemodynamics, and renal function. However, in consideration of differences in the environment, purpose, and area of scanning at various institutions, it would be extremely difficult to comprehensively evaluate these factors and establish a method for the administration of the contrast medium applicable to all institutions.…”

Section: Discussionmentioning

confidence: 99%

“…Contrastenhanced CT is particularly effective for clarification of internal properties and extent of the lesion and the spatial relationships between blood vessels and the lesion. In intravenous contrast-enhanced CT, it is desirable to maintain the concentration of the contrast medium in blood as high and stable as possible from the beginning to the end of scanning, but this is made difficult by the current techniques 2,[5][6][7]9,11,12,14) for the administration of the contrast medium and by consideration of the patient problems 2,8,10,15) . The concentration of the contrast medium is also affected by the types of medium and CT system used.…”

Section: Introductionmentioning

confidence: 99%

Contrast-Enhanced Conventional CT in Patients after Surgery for Malignant Tumors. Evaluation of the Optimal Method of the Administration of the Contrast Medium.

Wakoh

Yamada

Mori

et al. 2000

Bull. Tokyo Dent. Coll.

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Patients after ablative surgery for malignant tumors require computed tomography (CT) examination of a wide area on the head and neck to follow-up for recurrence and lymph metastasis. The aim of this study was to determine a more effective method for the infusion of the contrast medium into post-operative patients undergoing conventional CT, based on the relationship between the method of administering the contrast medium and the contrast-enhancing effect in the internal jugular vein. First eleven images were selected from the existing contrast-enhanced and plain CT images in a manner such that the CT values of the internal jugular vein were distributed evenly in a range of 50-180. Seven experienced observers evaluated the contrast-enhancing effect of each image set at a window value of 40 and window widths of 120, 200, and 280. Secondly, the CT values of the right internal jugular vein were measured in a total of 10 CT images from the thyroid to maxillary sinus level from each of 60 post-operative patients. The injection needles and contrast-enhancing techniques used in the 60 patients were drip infusion using an 18G injection needle in 20, drip infusion using a 21G injection needle with bolus intravenous injection immediately before scanning in 20, and drip infusion using a 23G injection needle with bolus intravenous injection immediately before scanning in 20. A CT value of 100 or above, preferably 120 or above, in the internal jugular vein was needed for the contrast-enhancing effect of a CT image to be judged as clinically significant.Our results found that, when a conventional CT was used in patients after surgery for malignant tumors, drip infusion using a 21G or 23G injection needle should be combined with bolus injections immediately before the beginning of scanning, and at the glottis or submandibular gland level during the scanning. A sufficient contrast-enhancing effect can also be obtained by drip infusion using an 18G injection needle without bolus injection.

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“…Thus, vascular tumours can be hypodense, compared with liver parenchyma during this phase. Although the arterial phase is most sensitive in the detection of HCC, the equilibrium phase is sometimes considered the second-most sensitive phase (38,39). However, the radiologist is responsible for determining the timing and appropriate phases of the scan protocol, and for One study compared CT with MRI imaging, gadolinium-enhanced multiphase dynamic MRI and multiphase multidetector-CT (MDCT) scanning for detecting small HCC (40).…”

Section: Computed Tomography In Diagnosis Of Hepatocellular Carcinomamentioning

confidence: 99%

Radiological diagnosis of hepatocellular carcinoma

Saar

Kellner-Weldon

2008

Liver International

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Treatment of hepatocellular carcinomas (HCC) is often complicated by the fact that early HCCs are mostly asymptomatic and the carcinoma is often discovered at an advanced stage. The aim of diagnostic imaging is to detect HCC at an early stage, when curative options are available. In recent years, there have been many efforts to improve early detection of small HCC. The purpose of this article is to describe the pertinent findings of HCCs in non-invasive, diagnostic imaging, including ultrasound, computed tomography, as well as modern magnetic resonance imaging techniques. Special emphasis is given to the frequently addressed difficulties of differentiation of precancerous lesions and small HCCs. A non-invasive diagnostic approach is considered with a review of the literature.

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Multiple-phase helical CT of the liver for detecting small hepatomas in patients with liver cirrhosis: contrast-injection protocol and optimal timing.

Cited by 152 publications

References 5 publications

Using triphasic helical CT to detect focal hepatic lesions in patients with neoplasms.

Using triphasic helical CT to detect focal hepatic lesions in patients with neoplasms.

Contrast-Enhanced Conventional CT in Patients after Surgery for Malignant Tumors. Evaluation of the Optimal Method of the Administration of the Contrast Medium.

Radiological diagnosis of hepatocellular carcinoma

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