Multiple Pigmented Basal Cell Carcinomas

Abstract

Basal cell carcinoma is the most common of all skin cancers and the most prevalent one among Caucasians. Rarely, these tumors are seen in other races. We report a 77-year-old Korean woman who presented with multiple darkly pigmented enlarging nodules on her scalp, face, trunk, and extremities. The patient had first noted a 6-mm pigmented lesion on her left eyebrow 10 years previously. Since then, other lesions had appeared in many locations on her body. She had been otherwise healthy and without a history of exposure to arsenic or radiation. There was no family history of skin cancer, xeroderma pigmentosum, or basal cell nevus syndrome. On physical examination, multiple darkly pigmented dome-shaped papules and nodules were present on her scalp, face, right forearm, lower abdomen, and inguinal areas. They ranged in size from 0.5 mm to 2 cm. The larger ones showed central ulceration. Multiple biopsy specimens from different sites showed pigmented basal cell carcinomas. Clinically, there was no evidence of nevus sebaceus, xeroderma pigmentosum, basal cell nevus syndrome, or immunodeficiency. Clinical workup including chest radiography, abdominal ultrasound, bone scan, and brain computerized axial tomography scan did not demonstrate primary or secondary tumors. The results of serologic and hematologic tests were also within normal limits. This is an unusual case report of multiple pigmented basal cell carcinomas in an Asian woman without any predisposing risk factors.

Superficial Type of Multiple Basal Cell Carcinomas: Detailed Comparative Study of Its Dermoscopic and Histopathological Findings

“…As the lesion progresses, the rimming gradually may become unclear [5, 7], as seen in this present case. As the superficial type of BCC shows a series of these developmental processes, it finally forms a scar formation in the inner side of the lesion, together with scattered pigmented structures [2, 3]. Arborizing vessels and blue-gray ovoid nests are rather unremarkable compared to those seen in other types of BCC.…”

“…Although the gross findings noted in basal cell carcinomas (BCCs) have been quite varied, there are several common diagnostic characteristics, including peripheral small nodules, ulcer formation (“rodent ulcer”) [1], and black color (especially in Japanese [2, 3] and black people [4]). Recently, the spread of dermoscopy and accumulation of dermoscopic findings have improved the diagnostic accuracy of BCC [5].…”