2011
DOI: 10.1021/ja205687k
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Multiple Polymersomes for Programmed Release of Multiple Components

Abstract: Long-term storage and controlled release of multiple components while avoiding cross-contamination have potentially important applications for pharmaceuticals and cosmetics. Polymersomes are very promising delivery vehicles but cannot be used to encapsulate multiple independent components and release them in a controlled manner. Here, we report a microfluidic approach to produce multiple polymersomes, or polymersomes-in-polymersome by design, enabling encapsulation and programmed release of multiple components… Show more

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Cited by 224 publications
(243 citation statements)
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“…In this later case, different bioactive agents can be encapsulated in separate to offer a programmed release that relies on the sequential dissociation of the membranes. [ 237 ] Nanosized poly(trimethylene carbonate)-b-poly( L -glutamic acid) polymersomes were encapsulated in larger ones, composed by PBut-b-PEO, creating independent compartments in each particle. [ 238 ] The lumen of the nanosized vesicle is one compartment and the cavity of the giant polymersome is other compartment.…”
Section: Reviewmentioning
confidence: 99%
“…In this later case, different bioactive agents can be encapsulated in separate to offer a programmed release that relies on the sequential dissociation of the membranes. [ 237 ] Nanosized poly(trimethylene carbonate)-b-poly( L -glutamic acid) polymersomes were encapsulated in larger ones, composed by PBut-b-PEO, creating independent compartments in each particle. [ 238 ] The lumen of the nanosized vesicle is one compartment and the cavity of the giant polymersome is other compartment.…”
Section: Reviewmentioning
confidence: 99%
“…This operates over a wide range of flow rates of the innermost, middle, and continuous phases, thereby enabling stable production of the double-emulsion drops in each drop makers in the parallelized device, though the flow rates in each drop maker are slightly different from one another. The resultant double-emulson drops exhibit dewetting of the middle oil phase on the surface of the innermost water drops, followed by subsequent separation of the oil, creating polymersomes whose membranes are composed of a bilayer of amphiphilic diblock-copolymers (Shum et al 2011;Kim et al 2011c). …”
Section: Introductionmentioning
confidence: 99%
“…Multiple emulsion drops containing two or more inner droplets can be used as templates for preparation of nonspherical polymersomes Kim et al, 2011b) and colloidosomes (Lee & Weitz, 2009) with multiple inner compartments. Two T-junction drop makers with alternating surface wettability shown in Fig.…”
Section: Multiple Emulsion Drops With Controlled Number Of Inner Dropmentioning
confidence: 99%