Multiple prenatal stresses increase sexual dimorphism in adult offspring behavior

Verstraeten, Barbara; McCreary, J. Keiko; Falkenberg, Erin A.; Fang, Xin; Weyers, Steven; Metz, Gerlinde A. S.; Olson, David M.

doi:10.1016/j.psyneuen.2019.05.003

Cited by 11 publications

(8 citation statements)

References 84 publications

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“…Based on these available studies it seems that even though PRS-exposed young female rodents more often develop increased anxiety-related behaviour when compared to males, this likely depends on the rodents' strain and the type and intensity of PRS (M. Schroeder et al, 2013;Mychasiuk et al, 2011). In adulthood, PRS induced sex-differences were also modest; mostly both PRS-exposed males and females displayed increased anxiety-related behaviour (Salomon et al, 2011;Kohman et al, 2008;Ribes et al, 2010;Richardson et al, 2006;Verstraeten, 2019;Zohar et al, 2016). However, from the experiments showing a sex-effect, increased anxiety-related behaviour was more often reported in males Green et al, 2018;Verstraeten, 2019;Brunton and Russell, 2010;Said et al, 2015;Zuena, 2008) than in females (Schulz, 2014;Richardson et al, 2006;Van den Hove, 2014), possibly indicating increased vulnerability in males.…”

Section: Anxiety-like Behaviourmentioning

confidence: 99%

Sex-dependence and comorbidities of the early-life adversity induced mental and metabolic disease risks: Where are we at?

Reemst

Ruigrok

Bleker

et al. 2022

Neuroscience & Biobehavioral Reviews

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Section: Anxiety-like Behaviourmentioning

confidence: 99%

Sex-dependence and comorbidities of the early-life adversity induced mental and metabolic disease risks: Where are we at?

Reemst

Ruigrok

Bleker

et al. 2022

Neuroscience & Biobehavioral Reviews

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“…Allostatic load (AL), in contrast, reflects the body’s “wear and tear” when the mediators of allostasis fail to promote resilience but rather accumulate the biological burden associated with repeated stressful hits [ 248 ]. Notably, the aging trajectory reflects the cumulative impact of wear and tear previous ancestral, prenatal and lifetime psychological, physical and inflammatory stressors, with each stress representing a “hit” [ 23 , 249 , 250 ]. High AL or unproductive resilience to stressors with cumulative wear and tear induced by multiple stress hits seems a hallmark of aging in a gender-based trajectory [ 251 , 252 ], reduces longevity [ 253 ], and ultimately predicts frailty, morbidity and mortality [ 254 ].…”

Section: Social Interaction: the Precursor Of Psychobiological Integritymentioning

confidence: 99%

Aging, Social Distancing, and COVID-19 Risk: Who is more Vulnerable and Why?

Faraji¹,

Metz²

2021

Aging and disease

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Perceived social support represents an important predictor of healthy aging. The global COVID-19 pandemic has dramatically changed the face of social relationships and revealed elderly to be particularly vulnerable to the effects of social isolation. Social distancing may represent a double-edged sword for older adults, protecting them against COVID-19 infection while also sacrificing personal interaction and attention at a critical time. Here, we consider the moderating role of social relationships as a potential influence on stress resilience, allostatic load, and vulnerability to infection and adverse health outcomes in the elderly population. Understanding the mechanisms how social support enhances resilience to stress and promotes mental and physical health into old age will enable new preventive strategies. Targeted social interventions may provide effective relief from the impact of COVID-19-related isolation and loneliness. In this regard, a pandemic may also offer a window of opportunity for raising awareness and mobilizing resources for new strategies that help build resilience in our aging population and future generations.

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“…Male, but not female prenatally stressed offspring show less active stress coping behaviours in the forced swim and tail suspension test, and anhedonia in the sucrose preference test; behaviours which are considered to be indicative of a depressive-like phenotype (Mueller & Bale, 2008). However, these sex differences seem to be dependent on the species, stress paradigm used, the timing of the stress exposure and the age of the animals at testing, as some studies report greater anxiety-and depressive-like behaviour in the offspring of both sexes (Fride & Weinstock, 1988;Butkevich et al, 2019;Verstraeten et al, 2019) or that females are more affected than males (Keshet & Weinstock, 1995;Richardson et al, 2006;Sickmann et al, 2015).…”

Section: Sex Differences In Early Life Stress Effectsmentioning

confidence: 99%

Sex, stress and steroids

Sze

Brunton

2019

Eur J of Neuroscience

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The hypothalamo-pituitary-adrenal (HPA) axis plays a key role in the neuroendocrine response to stress and in maintaining physiological homeostasis. However, stress that is chronic in nature can lead to HPA axis dysfunction and increase the risk for developing affective disorders, particularly if the stress is experienced during vulnerable periods in life. Sex differences in how the HPA axis responds to stress are well established, with females typically displaying heightened responses. The underlying cause of these sex differences are important to understand, as many neuropsychiatric disorders disproportionately affect females.Much research has provided evidence for gonadal sex steroids in underpinning sex differences in HPA axis responsivity, however we suggest that neuroactive metabolites of these steroids also play a key role in the brain in mediating sex differences in HPA axis responses to stress.The relationship between neuroactive steroids and stress is complex. Acute stress rapidly increases neuroactive steroid production, which can in turn modulate activity of the HPA axis.However under chronic stress conditions, stress can impact the brain's capacity to generate steroids, and this in turn has corollary effects on HPA axis function that may increase the propensity for psychopathology, given both HPA axis dysfunction and deficits in neuroactive steroids are implicated in affective disorders. Hence here we review the evidence from animal and human studies for sex differences in the interactions between neuroactive steroids and the stress axis at various stages of life, under physiological and pathophysiological stress conditions and consider the implications for health and disease.

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Multiple prenatal stresses increase sexual dimorphism in adult offspring behavior

Cited by 11 publications

References 84 publications

Sex-dependence and comorbidities of the early-life adversity induced mental and metabolic disease risks: Where are we at?

Sex-dependence and comorbidities of the early-life adversity induced mental and metabolic disease risks: Where are we at?

Aging, Social Distancing, and COVID-19 Risk: Who is more Vulnerable and Why?

Sex, stress and steroids

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