Multiple Primary Brain Tumors of Different Histological Types

Tokunaga, Takayuki; Shigemori, Minoru; Hirohata, Masaru; Sugita, Yasuo; Miyagi, Jun; Kuramoto, Shinken

doi:10.2176/nmc.31.141

Cited by 21 publications

(13 citation statements)

References 10 publications

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“…Various hypotheses have been proposed to explain this phenomenon. Pure coincidence, genetic predisposition, and the possibility that one tumor may serve as an irritating factor that leads to the growth of the second tumor [11,12]. Among recipient intracranial tumors, meningiomas are the most common, with many studies reporting collision tumors between various primary tumors, including renal cell carcinomas, breast cancers, and lung cancers, and meningiomas [1,[13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Collision Metastasis of Chronic Lymphocytic Leukemia and Glioblastoma: A Case Report

Yan¹,

Lakis²,

Stopa³

et al. 2017

J Clin Exp Pathol

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Collision tumors or metastasis from an extracranial tumor to a primary brain neoplasm are rare but do occur. The majority involve metastases to meningiomas. This case presents the second documented collision of a systemic chronic lymphocytic leukemia (CLL) to a glioblastoma multiforme (GBM). Lymphomas tend to coalesce in perivascular locations, and the characteristic vascularity of glioblastomas may present a very inviting milieu for lymphoma cells.

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Section: Discussionmentioning

confidence: 99%

Collision Metastasis of Chronic Lymphocytic Leukemia and Glioblastoma: A Case Report

Yan¹,

Lakis²,

Stopa³

et al. 2017

J Clin Exp Pathol

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“…1,4,5,[9][10][11]14) One case of pituitary chromophobe adenoma associated with hemangioblastoma of the cerebellum occurred among 2023 cases of intracranial tumors of Cushing's series, 11) 10) 82/M stromal astrocytosis cerebellar -no Tokunaga et al (1991) 14) 49/M acoustic neurinoma cerebellar -no Mariani and Seiler (1999) 9) 42/M pituitary macroprolactinoma cerebellar -yes Akusu et al (2005) …”

Section: Discussionmentioning

confidence: 99%

Coexistence of Sporadic Cerebellar Hemangioblastoma and Pituitary Null Cell Adenoma: Simultaneous Expression of von Hippel-Lindau Gene Product

Shimoda

Ogawa

Endo

et al. 2012

Neurol. Med. Chir.(Tokyo)

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Coexistence of brain tumors of different pathologies is rare, and the majority of the cases were related to genetic disorders or secondary tumors occurring after radiotherapy. A 73-year-old man was introduced to the outpatient department suffering from severe nausea and vertigo. Magnetic resonance imaging showed a cystic tumor in the left cerebellar hemisphere and another lesion in the sella turcica. There was no evident family history of von Hippel-Lindau (VHL) disease, and the systemic investigation failed to detect any other tumors or signs of VHL disease. Treatment was performed in two stages, and he was discharged with remaining slight ataxic gait. The diagnoses were cerebellar hemangioblastoma and pituitary null cell adenoma. Additional immunohistochemical investigation using VHL disease gene-related protein in both tumors showed minute granular positive staining in the cytoplasm of stromal cells in the former, and diffuse and strong granular cytoplasmic positive staining in the latter. Further analysis is required to confirm the true implication of the VHL gene mutation, and the possible involvement of VHL gene-related protein in the pathogenesis of these coexisting tumors.

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“…Meningiomas and gliomas are the most frequently reported combination of histologically different brain tumors [6]. …”

Section: Discussionmentioning

confidence: 99%

“…The observation that a significant number of the reported cases had their tumoral localization in juxtaposition raises the possibility that one tumor may act as an irritating agent for the local proliferation and growth of the other [6,11,12]. A purely coincidental event has been suggested by others [6,11,12]. Surgical trauma, ionizing radiation and genetic factors may influence tumor development [4].…”

Section: Discussionmentioning

confidence: 99%