Multiple Primary Cancers: Primary Malignant Lymphomas and Carcinomas of the Intestinal Tract in the Same Patient

Cornes, J. S.

doi:10.1136/jcp.13.6.483

Cited by 36 publications

(19 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Eighteen case reports have been previously published since Cattell's report in 1947, as shown in Table 1. 5,6,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Adenocarcinomas were located in the cecum in 3, in the ascending colon in 2, in the transverse colon in 1, in the descending colon in 1, in the sigmoid colon in 2, and in the rectum in 10 of 19 lesions. On the contrary, lymphomas were located in the cecum in 7, in the ascending colon in 3, in the transverse colon in 1, in the descending colon in 1, and in the rectum in 7 of 19 lesions.…”

Section: Discussionmentioning

confidence: 95%

“…5 Furthermore, lymphoma accompanied synchronously by adenocarcinoma of the colon is extremely rare. 6 Malignant lymphoma is a disease associated with disorders of the immune system, and investigating cases with a collision of malignant lymphoma and adenocarcinoma is interesting in terms of carcinogenesis and/or the progression of carcinoma. The present report describes a case of a collision tumor of primary follicular lymphoma and adenocarcinoma in the cecum, in which the regional lymph nodes were involved by lymphoma, and not by adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: Report of a case

Sasaki¹,

Hatanaka²,

Sahara³

et al. 2010

Surg Today

View full text Add to dashboard Cite

This report presents the case of a 62-year-old man with a collision tumor of primary malignant lymphoma and adenocarcinoma in the cecum. All regional mesenteric lymph nodes that were removed surgically were found to be occupied by lymphoma cells and no lymph nodes contained any cancer cells, although the primary carcinomas did exhibit lymphatic invasion. Malignant lymphoma was also seen in the duodenum. Systemic chemotherapy was administered for the malignant lymphoma, and a complete response was thus obtained. However, just after chemotherapy multiple liver metastases of adenocarcinoma emerged, and chemotherapy against adenocarcinoma was therefore continued. The occurrence of synchronous lymphoma and adenocarcinoma of the colorectum is rare. Furthermore, collisions of these different entities are also extremely unusual; so far only five such case reports have been published. The accurate clinical determination of the dominant tumor and a close follow-up is required for proper treatment in these cases.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: Report of a case

Sasaki¹,

Hatanaka²,

Sahara³

et al. 2010

Surg Today

View full text Add to dashboard Cite

show abstract

“…It has been postulated that lymphoma might predispose the colon to adenocarcinoma because of altered immune function, allowing for cancerous cells to grow without surveillance. Cornes and others [12][13][14] observed that, in coexisting tumours, adenocarcinomas occur either synchronously with or after a diagnosis of lymphoma in the intestinal tract, suggesting an association between those two cancer types. Nonetheless, the rarity of such cases prevents any firm establishment of a relationship between lymphomas and adenocarcinomas 11,15 .…”

Section: Discussionmentioning

confidence: 99%

Synchronous Rectal Adenocarcinoma and Splenic Marginal Zone Lymphoma

et al. 2016

View full text Add to dashboard Cite

Synchronous cancers of different primary origin are rare. Here, we describe the case of a patient with concomitant diagnoses of rectal adenocarcinoma and splenic marginal zone lymphoma (smzl).A 57-year-old woman initially presented with abdominal pain. Physical examination and computed tomography demonstrated massive splenomegaly, and a complete blood count revealed microcytic anemia and lymphopenia. During the subsequent evaluation, she presented with hematochezia, melena, and constipation, which prompted gastroenterology referral. Subsequent endoscopic rectal ultrasonography revealed a T3N1 moderately differentiated rectal adenocarcinoma, with computed tomography imaging of chest, abdomen, and pelvis confirming no metastasis. Thus, the cancer was classified as clinical stage T3N1M0, stage iii. Bone marrow biopsy confirmed co-existing marginal zone lymphoma, and with the clinical presentation of massive splenomegaly, a diagnosis of smzl was made.The patient's management was individually tailored for simultaneous optimal treatment of both conditions. Concurrent treatment with neoadjuvant rituximab and 5-fluorouracil chemotherapy, with external-beam radiation therapy to the pelvis, was administered, followed by surgery consisting of en bloc splenectomy and distal pancreatectomy, and low anterior resection. The patient completed a standard course of adjuvant folfox (fluorouracil-leucovorin-oxaliplatin) chemotherapy and has remained disease-free for 7 years.To our knowledge, this report is the first to specifically describe simultaneous diagnoses of locally advanced rectal cancer and smzl. We also describe the successful combined neoadjuvant treatment combination of 5-fluorouracil, rituximab, and pelvic radiation.

show abstract

“…3 Lee et al 1 consider that old age and decreased immunity may be the risk factors for coexisting primary malignant lymphoma and colon adenocarcinoma in one patient. Cornes 4 reported that coexisting adenocarcinomas either ocur synchronously or follow, but never precede lymphoma. In addition, the current lymphoma extended systemically and occupied the regional lymph node, thus suggesting that lymphoma preceded the adenocarcinoma and was predominant.…”

Section: Dear Editor;mentioning

confidence: 99%

Coexisting Primary Malignant Lymphoma and Adenocarcinoma of the Intestinal Tract

Ezer¹,

Parlakgümüş²

2017

TJCD

View full text Add to dashboard Cite

Multiple Primary Cancers: Primary Malignant Lymphomas and Carcinomas of the Intestinal Tract in the Same Patient

Cited by 36 publications

References 9 publications

Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: Report of a case

Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: Report of a case

Synchronous Rectal Adenocarcinoma and Splenic Marginal Zone Lymphoma

Coexisting Primary Malignant Lymphoma and Adenocarcinoma of the Intestinal Tract

Contact Info

Product

Resources

About