Multiple primary cutaneous plasmacytomas: Figure 1

Multiple primary cutaneous plasmacytoma a decade after a nasal solitary extramedullary plasmacytoma: a puzzling case

“…Diagnosis is based on clinical, histological, and immunochemical findings. Clinically, PCP patients develop solitary or multiple erythematous-violaceous subcutaneous papules, nodules, and/or plaques with a diameter from 1 to 5 cm, with a predilection for the face, trunk, and extremities [4,9], as was our patient's case. However, some authors state that there are no predilection sites [8,10].…”

“…Within the EMP group, solitary extramedullary plasmacytomas (SEP) are usually localized in the upper respiratory tract and constitute around 3-5% of all plasma cell neoplasms [7,8]. Some patients have a small monoclonal protein, in the serum or urine, that disappears after treatment [3,4,9]. In our patient, no monoclonal component was detected at the time of the nasal plasmacytoma; however, it was detected 2 years before the second episode.…”

“…This technique also allows distinguishing reactive plasma cell proliferation by infections or inflammatory processes from PCP . Diagnostic criteria include cytoplasmic expression of immunoglobulins restricted to one immunoglobulin chain and exclusion of underlying myeloma through laboratory, radiological, and bone marrow investigations . All of these criteria were met in our patient's case.…”

“…Therapy options range from surgical excision plus radiotherapy in the case of solitary plasmacytomas [1,6], to systemic therapy in the case of multiple lesions, as occurred in our case [4,9]. Novel agents, such as proteasome inhibitors and immunomodulatory drugs, have been recently introduced in the treatment of patients with MM, and they have showed to be also effective in EMP, especially for proteasome inhibitors [15,16].…”

Treatment and Outcomes for Primary Cutaneous Extramedullary Plasmacytoma: A Case Series

“…Furthermore, details of treatment are poorly described; many case reports focus only on the pathologic diagnosis 3,[8][9][10][11] . Although extramedullar y plasmacytomas are associated with good clinical outcomes, patients with pcp can develop local recurrence, distant skin recurrence, or systemic progression to multiple myeloma 1,2 .…”