Multiple Primary Malignancies Combined With Esophagus and Other Organs

Sekiguchi, Masayuki; Takagi, Iwao; Kunishima, Kazuo

doi:10.3919/ringe1963.51.2371

Cited by 8 publications

(6 citation statements)

References 6 publications

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“…As for multiple primary cancers of the esoph- agus and other organs, priority in treatment should be given to the cancer with the worst prognosis. Shinoda et al 19 reported that the prognosis of multiple primary cancers mainly depended on the prognosis of primary esophageal carcinoma. If each of the multiple primary cancers can be curatively resected, the prognosis is relatively fair 20 .…”

Section: Discussionmentioning

confidence: 99%

Undifferentiated Carcinoma of the Esophagus with Rapid Growth of Lymph Node. A Case Report and Review of the Literature

Mori

Tagaya

Hamada

et al. 2008

Tumori

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We present a case of undifferentiated carcinoma of the esophagus (UCE) treated with chemotherapy consisting of 5-fluorouracil plus nedaplatin and radiotherapy. The patient developed rapid growth of lymph nodes and died of massive hematemesis 2 months after the diagnosis. UCE is rare but highly malignant. Since there is no established treatment for UCE, its clinical outcome is invariably poor. We also reviewed the effectiveness of chemotherapy against UCE.

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Section: Discussionmentioning

confidence: 99%

Undifferentiated Carcinoma of the Esophagus with Rapid Growth of Lymph Node. A Case Report and Review of the Literature

Mori

Tagaya

Hamada

et al. 2008

Tumori

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“…1,2 Nevertheless, triple cancers are rare and few cases have been described in the literature. We present herein the case of a patient In December 1996, the patient presented again, complaining of a feeling of discomfort in the chest.…”

Section: Introductionmentioning

confidence: 99%

Metachronous Triple Cancers of the Sigmoid Colon, Stomach, and Esophagus: Report of a Case

Iioka¹,

Tsuchida²,

Okubo³

et al. 2000

Surgery Today

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We report herein an unusual case of metachronous triple cancers of the sigmoid colon, stomach, and esophagus. A 60-year-old man was initially admitted to our hospital for investigation of occult fecal blood. This was found to be caused by sigmoid colon cancer which was resected in July 1985 (T3, N0, M0; Stage II). A follow-up endoscopy performed in 1990 showed early gastric cancer, and a gastrectomy was performed in August 1990 (Tis, N0, M0; Stage 0). Another endoscopic examination performed as follow-up in 1993 revealed early cancer of the remnant stomach, and all the remnant stomach was surgically resected in March 1993 (Tis, N0, M0; Stage 0). He presented again in December 1996, complaining of discomfort in the chest which was found to be caused by cancer of the middle thoracic esophagus. Although surgery was considered necessary, the patient refused to undergo any further operations. Instead, radiation was administered from January 1997. An endoscopy after the completion of radiotherapy confirmed that the cancer had almost disappeared; however, it started to grow again from the beginning of 1998. He was hospitalized due to esophageal stenosis in April 1998, and died of carcinomatous cachexia in September of the same year.

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“…Synchronous colonic cancers are common and have been identified in about 20% of colonic resection segments, 1,2 but synchronous upper gastrointestinal (GI) malignancies are relatively uncommon 3 . It has been reported that number of diagnosed multiple primary cancers has been increasing, 4 and it is possible that the frequency of synchronous esophageal cancers, gastric cancers or duodenal cancers is also increasing due to the application of advanced diagnostic tools, in particular, the upper GI endoscopy, and the prolonged life span of the general population.…”

Section: Introductionmentioning

confidence: 99%

Clinical presentation, endoscopic features, treatment and prognosis of synchronous upper gastrointestinal malignancies

Bai

Zou

2011

J of Digest Diseases

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OBJECTIVE:To study the clinical presentation, endoscopic features and prognosis of patients with synchronous upper gastrointestinal (GI) cancers. METHODS:A prospective database review of consecutive patients with synchronous upper GI malignancies was performed in a tertiary university hospital endoscopy unit. Gender, age, symptoms and cancer sites, endoscopic and pathological findings, as well as the long-term survival of these patients were analyzed. RESULTS:A total of 64 patients with a median age of 56 years were included, in which 81.3% were male, 71.9% presented with notable features, 68.8% had familial history of cancer, 56.3% of gastric cancers were at the gastric body, 92.9% of the duodenal malignancies at the duodenal bulb, all esophageal cancers at the middle and lower part of esophagus and a significant proportion of tumors in the synchronous malignancies group were poorly differentiated. In all patients, 20 underwent curative surgical treatment and the 5-year survival rate was only 20%. CONCLUSIONS:Patients with synchronous upper GI cancers are mainly male and present with different anatomic distribution and endoscopic features. They carry a poor prognosis as compared with single primary cancer patients. This case series describes the clinical profiles and emphasizes the necessity of a thorough examination for additional cancers before treatment of upper GI cancer.

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Multiple Primary Malignancies Combined With Esophagus and Other Organs

Cited by 8 publications

References 6 publications

Undifferentiated Carcinoma of the Esophagus with Rapid Growth of Lymph Node. A Case Report and Review of the Literature

Undifferentiated Carcinoma of the Esophagus with Rapid Growth of Lymph Node. A Case Report and Review of the Literature

Metachronous Triple Cancers of the Sigmoid Colon, Stomach, and Esophagus: Report of a Case

Clinical presentation, endoscopic features, treatment and prognosis of synchronous upper gastrointestinal malignancies

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