Multiple primary malignancies in patients with renal cell carcinoma: a national population‐based cohort study

Abstract

expected number of different tumour types was calculated according to age group, gender and observation time. RESULTSOf the 1425 patients, 228 (16%) had one, 23 (1.6%) had two, three (0.2%) had three and one (0.07%) had four other primary malignancies. In all, 100 (34.8%) of the other tumours were diagnosed as antecedent, 53 (18.7%) as synchronous and 134 (46.7%) as subsequent to the RCC. Cancer in the prostate, bladder, lung, breast, colon and rectal cancer, malignant melanomas (MM) and non-Hodgkin's lymphomas (NHL) were the most common other malignancies. The observed overall number of subsequent other malignant tumours was 22% higher than the expected number. The observed number of subsequent tumours was significantly higher for bladder cancer, NHL and MM. The estimated 15-year cumulative risk for patients with RCC and no previous or synchronous other malignancy for developing a later second cancer was 26.6% in men, and 15.5% in women (statistically significant, P = 0.04). Patients with antecedent or synchronous other cancer had significantly poorer overall survival than those without. CONCLUSIONSPatients with RCC seem to have a significantly higher risk of developing other subsequent primary malignancies. This should be considered during the follow-up of patients with RCC.

Urothelial Cancer and the Diagnosis of Subsequent Malignancies

“…[1][2][3][4] Multiple primaries, as defined by the International Agency for Research on Cancer (IARC), are those cancers which develop in several primary sites that are not an extension, recurrence nor metastasis of each other. Multiple primaries also include tumours arising from the same site but with different morphologies.…”

Neuroendocrine breast carcinoma metastatic to renal cell carcinoma and ipsilateral adrenal gland

“…RCC is the most common tumor found to coexist with other malignancies [1,10,12,13,14]. In different studies the incidence of second primary malignancy associated with RCC is reported to be 12%-27.4% [1,10,11,14]. About 19% of these tumors appeared synchronously [1].…”

“…In different studies the incidence of second primary malignancy associated with RCC is reported to be 12%-27.4% [1,10,11,14]. About 19% of these tumors appeared synchronously [1]. Other primary malignant tumors most often associated with RCC are bladder, prostate, colorectal and lung cancer [1,10,12,20].…”

“…Other primary malignant tumors most often associated with RCC are bladder, prostate, colorectal and lung cancer [1,10,12,20]. Breast cancer is also one of the tumors known to coexist with RCC [1,11].…”

Synchronous Primary Malignancies in Breast and Kidney: A Rare Case Report

“…Literature reveals that renal cell carcinoma has been associated with other primary malignancies (synchronous and metachronous); like those of colon [2], rectum [2], stomach [5], prostate [2], bladder [2], endometrium [1], ovary [1], breast [2], nasopharynx [5], lung [6] and haematological malignancies.…”