Multiple primary malignancies: synchronous lymphoma, pancreatic neuroendocrine tumour and colorectal cancer

Abstract

A 67-year-old woman underwent a medical check-up by her general practitioner after complaining of atypical pain in the shoulder girdle. Due to the important inflammatory syndrome noticed on blood testing, a polymyalgia rheumatica was suspected and she was started on corticosteroid treatment with good clinical response, but no impact on inflammation. She underwent extensive imaging with a thoraco-abdominal CT scanner that demonstrated a pancreatic mass, then later a PET-CT showed 3 different hyperactive lesions. Biopsies then revealed simultaneous diffuse large B-cell lymphoma (DLBCL), colorectal adenocarcinoma and pancreatic neuroendocrine tumour. She benefited from low rectal endoscopic excision of the colorectal tumour, R-CHOP chemotherapy for DLBCL and laparoscopic left pancreatectomy. Successful treatment required a good multidisciplinary collaboration between the different specialists. The patient made a good recovery and achieved complete remission at 1 year. This an unusual presentation of multiple primary malignancies.

Clinical and genetic characteristics in lymphoma patients with a second solid malignancy

“…Therefore, synchronous combination of lymphoma and other solid carcinomas are considered as a rare condition (14, 18-21). A few cases of synchronous double primary tumors of DLBCL and digestive carcinoma have been reported as rare case reports (22)(23)(24). In our five cases of synchronous double primary malignancies, two patients had synchronous DLBCL and colon adenocarcinoma.…”

A case report of synchronous triple primary malignancies: Diffuse large B-cell lymphoma, rectal adenocarcinoma and hepatocellular carcinoma

“…Therefore, we can state that the patient in this report suffered from synchronous MPM consisting of three tumors. The previously similar reported instances of synchronous triple primary malignancies including lymphoma and solid digestive system tumors are listed in Table 2 (6)(7)(8).…”

Prolonged, recurrent, spontaneous massive gluteal and femoral bleeding in a patient with five metachronous primary malignancies

“…An increase in overall life expectancy, improved cancer therapies and follow-up, and more sensitive detection modalities have allowed an increase in the reported frequency of multiple primary tumors in the range of 2%-17% (1,2). The term multiple primary malignancies commonly includes two large categories: if they are diagnosed simultaneously or within 6 months, they are called synchronous neoplasms, and if second-or higherorder malignancies follow at least 6 months after the previous one, they are called metachronous neoplasms (2).…”