Multiple primary malignant neoplasms in breast cancer patients in Israel

Schenker, Joseph G.; Levinsky, R A; Ohel, Gonen

doi:10.1002/1097-0142(19840701)54:1<139::aid-cncr2820540129>3.0.co;2-u

Cited by 59 publications

(24 citation statements)

References 21 publications

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“…Similarly, our own analysis echoes a similar increased risk of SPM following breast cancer at magnitude of 42 %. Specifically, breast cancer survivors are at increased risk of developing cancers of the contralateral breast, endometrium, ovary, colon, lung, skin, thyroid gland as well as leukaemia [2,9,14,47,48].…”

Section: Discussionsupporting

confidence: 65%

“…This has been confirmed by our own analysis, where the SIRs for patients with a second primary malignancy following thyroid cancer increased and showed approximately 21 % increased risk compared to the general population. Specifically, the risks of adrenal, bone and joints, breast, brain and CNS, colon and colorectal, kidney, non-Hodgkin's lymphoma, multiple myeloma, leukaemia, prostate, salivary gland, soft tissue sarcoma and stomach were increased [2,9,14,47,48]. Similarly, our own analysis echoes a similar increased risk of SPM following breast cancer at magnitude of 42 %.…”

Section: Discussionmentioning

confidence: 99%

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The association between breast cancer and thyroid cancer: a meta-analysis

Joseph

Edirimanne

Eslick

2015

Breast Cancer Res Treat

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Previous studies have suggested an association between breast cancer and thyroid cancer; however, there has not been a formal meta-analysis which collates the existing evidence supporting the hypothesis that breast cancer or thyroid cancer predisposes an individual to developing the other. A systematic search was carried out using PubMed and Medline. We searched for articles containing epidemiological evidence of breast cancer following thyroid cancer and vice versa. Additionally, we searched for articles that included epidemiological data involving the incidence of all second primary malignancies (SPMs) following both breast cancer and thyroid cancer, and compared the datasets. The meta-analysis performed in a total of 18 studies showed that there is a significantly increased risk of developing thyroid cancer as a second primary malignancy of breast cancer (SIR = 1.59, 95 % confidence interval (CI) 1.28-1.99). Additionally, there was marginally increased risk of developing breast cancer as a second primary malignancy of thyroid cancer (SIR = 1.24, 95 % CI 1.16-1.33), compared to the general risk of developing a second primary malignancy following thyroid cancer. The findings suggest that the risk of developing thyroid cancer as a second primary malignancy of breast cancer and vice versa is increased compared to the background risk of developing other SPMs. The risk of developing thyroid cancer after a primary breast cancer was higher than the risk of developing breast cancer as a second primary malignancy of thyroid cancer. This suggests that the effects of treatment-related factors and specific pathological processes of each cancer may contribute to the increased risk rather than common risk factors including genetic factors. Elucidation of the common mechanisms between breast cancer and thyroid cancer will have important implications in both diagnostic and therapeutic management of these cancers. Benefit of thyroid ultrasound screening after breast cancer surgery needs to be assessed.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

The association between breast cancer and thyroid cancer: a meta-analysis

Joseph

Edirimanne

Eslick

2015

Breast Cancer Res Treat

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“…The increased observed/expected ratio for small bowel cancer could also be a random finding. Increased risks after breast cancer, regularly reported for cancer of the colonrectum, ovary, and uterus (Schenker et al, 1984;Ewertz and Mouridsen, 1985;Harvey and Brinton, 1985;Teppo et al, 1985;Rutqvist et al, 1995) are partly explained by a common aetiology or pathogenesis (e.g., hormonal exposure or susceptibility). The decreased risk for tobacco-related cancers in the lung and head and neck area could also be related to the high socio-economic status of breast cancer patients (Schrijvers et al, 1997), greater health awareness could also play a role.…”

mentioning

confidence: 99%

Excess mortality from breast cancer 20 years after diagnosis when life expectancy is normal

2001

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Summary In a population-based study, causes of death were traced of 418 deceased breast cancer patients diagnosed in 1960-1979 who survived at least 10 years after diagnosis. The pattern of causes of death in these patients was compared with the general female population using standardized mortality ratios (SMRs). Of 418 patients surviving at least 10 years, 196 (47%) died from breast cancer and 50 (12%) died from another cancer. The SMR for breast cancer was 15.8 (95% CI: 13.1-18.8) 10-14 years after diagnosis; it was still 4.7 (95% CI: 2.6-7.8) after 20 years. Overall mortality was higher than expected 10-14 years after diagnosis (SMR: 1.3; 95% CI: 1.1-1.5), but lower after more than 20 years (SMR: 0.6; 95% CI: 0.4-0.7). Despite a normal (or even improved) life expectancy for breast cancer patients 20 years after diagnosis the risk of dying from this disease remained elevated.

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“…Additional primary cancers occurring simultaneously with breast cancer have been reported in the opposite breast, salivary glands, uterine corpus, ovary and thyroid (9). To the best of our knowledge, the present case is the first report of concurring multiple primary malignancies of the breast and nasopharynx.…”

Section: Discussionmentioning

confidence: 93%

Case report of concurrent primary malignancies of the breast and nasopharynx

Pan

Zhu

2012

Oncology Letters

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Abstract. The aim of this study was to report a case of concurrent primary malignancies of the breast and nasopharynx and discuss the potential relationship between Epstein-Barr virus (EBV) infection and breast cancer. A 39-year-old female presented with a palpable mass present for 1 year in her left breast. Immunohistochemical staining was performed and the results showed that the tumor cells were immunopositive for the estrogen receptor, progesterone receptor and p53 protein, and markedly positive for C-erb B2. In addition, 30% of the tumor cells were positive for the Ki-67 antigen. Blood test results revealed that EBV-CA-IgG was present and EBV-EA-IgG was reactivated. The patient was diagnosed with breast cancer (T1N0M0) and EBV infection. A mastectomy with axillary clearance was performed on the left breast. Histopathological examination provided evidence of invasive ductal adenocarcinoma. Further evaluation due to epistaxis following the breast surgery resulted in a diagnosis of nasopharyngeal carcinoma (T2N1M0). Histopathology showed a non-keratinizing undifferentiated carcinoma. The patient was treated with chemoradiotherapy for nasopharyngeal carcinoma. Twelve months following surgery and chemoradiotherapy the patient was assessed at the Cancer Hospital of Guangxi Medical University outpatient clinic and no evidence of relapse or metastasis was found. Thus, EBV infection may be involved in the pathogenesis of breast cancer, as observed in nasopharyngeal carcinoma. IntroductionThe mechanisms responsible for the appearance of multiple primary cancers remain unclear. Among the factors most frequently involved are genetic susceptibility, the immune system and intensive exposure to carcinogens, including chemical and biological carcinogens and radiation.Breast cancer is the most common neoplastic disease of women in the Western world. In developed countries, more than 200 cases are diagnosed annually per 100,000 women. The etiology and mechanisms of breast cancer are poorly understood. Well-known risk factors, including those that affect circulating sex hormones and genetic background can only explain approximately 50% of all breast cancer cases. Among the remaining 50% of cases, findings of numerous studies have suggested that Epstein-Barr virus (EBV) infection may be a causal factor (1-4).EBV is a ubiquitous γ herpes virus and infects 90% of the population. In the majority of individuals, the virus persists for life in the memory B-cell pool (5) with no adverse health consequences. The virus is essentially a B-lymphotropic agent and is associated with malignancies of B-cell origin, including Burkitt's lymphoma. However, epithelial cell infection clearly occurs in vivo, as EBV is also associated with malignancies of epithelial origin, such as nasopharyngeal carcinoma (NPC). In Burkitt's lymphoma and NPC, epidemiological and molecular virological data favor the role of the virus as a cofactor in tumor initiation and/or development. The involvement of EBV has been demonstrated by the findings of EBNA-1 express...

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Multiple primary malignant neoplasms in breast cancer patients in Israel

Cited by 59 publications

References 21 publications

The association between breast cancer and thyroid cancer: a meta-analysis

The association between breast cancer and thyroid cancer: a meta-analysis

Excess mortality from breast cancer 20 years after diagnosis when life expectancy is normal

Case report of concurrent primary malignancies of the breast and nasopharynx

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