Multiple primary melanomas among 16,570 patients with melanoma diagnosed at Kaiser Permanente Northern California, 1996 to 2011

Moore, Megan; Geller, Alan C.; Warton, E. Margaret; Schwalbe, J.; Asgari, Maryam M.

doi:10.1016/j.jaad.2015.06.059

Cited by 56 publications

(86 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One of these cases occurred in a patient with neurofibromatosis type 1, which may have represented a unique inherited predisposition [6] . Multiple primary cutaneous melanomas, however, are not uncommon, ranging from 0.2 to 8.6% of primary melanomas [7][8][9][10][11][12][13] . The observed numbers in most studies are well beyond those expected by chance alone [7-10, 12, 13] .…”

Section: Discussionmentioning

confidence: 99%

“…The second melanoma in patients with two primaries tends to be thinner, on average, than the initial tumor [7][8][9][10][11][12][13] . In persons with multiple primary melanomas, Breslow thickness is the main determinant of prognosis [7][8][9][10][11][12][13] .…”

Section: Discussionmentioning

confidence: 99%

“…In persons with multiple primary melanomas, Breslow thickness is the main determinant of prognosis [7][8][9][10][11][12][13] . Other independent risk factors include mitotic index, ulceration, and location on the scalp [11] .…”

Section: Discussionmentioning

confidence: 99%

“…Family histories of melanoma and dysplastic nevi have been associated with multiple primary melanomas [12] . Importantly, second primary melanomas do not convey any added risk of mortality [7][8][9][10][11][12][13] .…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Separate Primary Melanomas of the Bulbar Conjunctiva and Eyelid Skin: Clinical Implications of Multiple Primary Melanomas

Jacinto¹,

Fisher²,

Espana³

et al. 2016

Ocul Oncol Pathol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Separate Primary Melanomas of the Bulbar Conjunctiva and Eyelid Skin: Clinical Implications of Multiple Primary Melanomas

Jacinto¹,

Fisher²,

Espana³

et al. 2016

Ocul Oncol Pathol

View full text Add to dashboard Cite

show abstract

“…58 Melanoma survivors are at increased risk of developing a second primary cancer at another site, especially skin cancers, but also cancers of the bone, soft tissue, colon and rectum, female breast, kidney, prostate, thyroid, non-Hodgkin lymphoma, and chronic lymphocytic leukemia. 59,60 In one study, melanoma patients receiving a BRAF inhibitor for metastatic disease (vemurafenib) had a 26% chance of developing a SCC within a median timeframe of approximately 8 weeks; most of the SCCs were keratoacanthomatype, which generally have a good prognosis.…”

Section: Risk Of Skin Cancer Among Cancer Survivorsmentioning

confidence: 99%

Ultraviolet Radiation Exposure and Its Impact on Skin Cancer Risk

Watson¹,

Holman²,

Maguire-Eisen³

2016

Seminars in Oncology Nursing

202

115

View full text Add to dashboard Cite

Objectives To review research and evidence-based resources on skin cancer prevention and early detection and their importance for oncology nurses. Data Sources Journal articles, federal reports, cancer surveillance data, behavioral surveillance data. Conclusion Most cases of skin cancer are preventable. Survivors of many types of cancer are at increased risk of skin cancers. Implications for Nursing Practice Oncology nurses can play an important role in protecting their patients from future skin cancer morbidity and mortality.

show abstract

Comparison of Survival Between Patients With Single vs Multiple Primary Cutaneous Melanomas

et al. 2019

View full text Add to dashboard Cite

IMPORTANCE Melanoma is one of the most rapidly increasing forms of cancer worldwide. Most studies about survival among patients with melanoma consider only the primary tumor and disregard the potential effect of multiple primary tumors. A better understanding of the prognosis of patients with multiple primary melanoma is important for patient counselling and follow-up strategies. OBJECTIVE To describe the epidemiologic features of multiple primary melanoma in patients from the Netherlands. DESIGN, SETTING, AND PARTICIPANTS This retrospective, population-based cohort study included adults with histologically proven, primary, invasive cutaneous melanoma in the Netherlands between January 1, 2000, and December 31, 2014, with a median follow-up of 75.1 months, using data from PALGA, the Dutch Nationwide Network and Registry of Histopathology and Cytopathology. Follow-up data were retrieved from the Netherlands Cancer Registry. Statistical analysis was performed from August 1, 2018, to September 3, 2018. MAIN OUTCOMES AND MEASURES A multivariable Cox model with a time-varying covariate was performed to assess overall survival between patients with a single primary melanoma vs those with multiple primary melanomas. Secondary outcomes included incidence of multiple primary melanoma, differences in Breslow thickness, and time between first and second multiple primary melanoma. RESULTS Of the 56 929 study patients, 31 916 (56.1%) were female, with a mean (SD) age of 56.4 (16.2) years. A total of 54 645 single primary melanomas and 4967 multiple primary melanomas in 2284 patients were included. The median Breslow thickness decreased from 0.90 mm (interquartile range, 0.55-1.70 mm) for the first melanoma to 0.65 mm (interquartile range, 0.45-1.10 mm) for the second melanoma (P < .001). For their second melanoma, 370 patients (16.2%) had a higher T stage, 1112 (48.7%) had the same T stage, and 802 (35.1%) had a lower T stage. In addition, 841 of 2284 second melanomas (36.8%) in patients with multiple primary melanomas were found during the first year of follow-up, whereas 624 of 2284 (27.3%) were found after 5 years of follow-up. These proportions did not vary when stratified for melanoma stage. Worse overall survival was seen among patients with multiple primary melanomas compared with patients with a single primary melanoma (hazard ratio, 1.31; 95% CI, 1.20-1.42; P < .001). CONCLUSIONS AND RELEVANCE A significant decrease in Breslow thickness between the first and second multiple primary melanoma was found, and overall survival among patients with multiple primary melanomas was significantly worse than that among patients with a single primary melanoma. These findings suggest that more strict follow-up strategies may be warranted for patients with multiple primary melanomas.

show abstract

Multiple primary melanomas among 16,570 patients with melanoma diagnosed at Kaiser Permanente Northern California, 1996 to 2011

Cited by 56 publications

References 11 publications

Separate Primary Melanomas of the Bulbar Conjunctiva and Eyelid Skin: Clinical Implications of Multiple Primary Melanomas

Separate Primary Melanomas of the Bulbar Conjunctiva and Eyelid Skin: Clinical Implications of Multiple Primary Melanomas

Ultraviolet Radiation Exposure and Its Impact on Skin Cancer Risk

Comparison of Survival Between Patients With Single vs Multiple Primary Cutaneous Melanomas

Contact Info

Product

Resources

About