Multiple primary pulmonary meningioma: A case report and literature review

Abstract

Lung cancer has become a leading cause of cancer‐related deaths. With the conventional use of low‐dose spiral computed tomography (CT) in physical examinations, an increasing number of small pulmonary nodules are screened. However, primary pulmonary meningiomas (PPMs) are rarely reported. Here, we report the case of a 64‐year‐old woman who had a CT scan during physical examination, which revealed three ground‐glass‐like opacity pulmonary nodules in both lungs. The patient underwent video‐assisted thoracoscopic wedge resection of the right upper and lower lobes. Paraffin sections revealed pulmonary meningothelial‐like and collagenous nodules in the right upper and lower lobes which stained as follows: EMA+, VIM+, SMA‐, S‐100‐, CD34‐, STAT6‐, Ki‐67+ (2%), and CgA‐. Primary pulmonary meningiomas (PPMs) were finally diagnosed. PPM is a kind of rare and benign tumor. Surgery can provide a precise pathological examination, and patients can achieve an excellent prognosis after surgical resection.

Multiple Primary Pulmonary Meningiomas. Case report and literature review.

“…Lung is the most common metastatic site with occurrence up to several years after the excision of the primary tumor. Ectopic meningiomas account for 2% of meningiomas and PPM is rare, whilst mPPM is exceptional, with only six patients (including our report) being reported to the best of our knowledge so far (11)(12)(13)(14)(15)(16)(17). PPM tends to occur in middle-aged females.…”

“…Pubmed research revealed 177 articles from 1968 to 2022, of which seven were considered eligible after ltering our initial selection (11)(12)(13)(14)(15)(16)(17). Three out of seven articles were authored by the same researchers and concerned the same patient (surgery, ten-and twenty-years follow-up).…”

Primary pulmonary meningioma with associated multiple micronodules: a case report and literature review

“…This manifestation is rare, and very few similar cases have been reported [ 7–9 , 33 ]. In two of these cases, different nodules were sampled, and histology confirmed the diagnosis of multiple PPM [ 7 , 8 ]. For other cases, the diagnosis was based on the histology of the largest lesion, and small nodules were on active surveillance [ 9 , 33 ].…”

Coexistence of primary pulmonary meningioma and metastatic papillary renal cell carcinoma of the lung: A rare case report with review of the literature

“…[ 8 ] PPM is more likely to occur in middle-aged and older women. [ 9 ] Although most patients are asymptomatic, some may have symptoms such as chest pain, coughing and hemoptysis. [ 10 ]…”

“…[8] PPM is more likely to occur in middle-aged and older women. [9] Although most patients are asymptomatic, some may have symptoms such as chest pain, coughing and hemoptysis. [10] In the most cases, PPM is usually found incidentally and often appears as solitary solid pulmonary nodules on chest CT scan.…”