Multiple pulmonary scar carcinomas in a patient with Hodgkin's Disease: Report of a case and review of the literature

Abstract

A case of multiple pulmonary scar carcinomas arising in a 53-year-old woman with Hodgkin's disease is reported. Review of the literature reveals that scar carcinoma is generally thought to arise in areas of bronchiolar epithelial proliferation occurring in association with pre-existing lung scars. However, we and others have emphasized that, given the usual gross and histologic picture of scar carcinoma, it is impossible to state with certainty whether the carcinoma arose in response to the scar tissue, or the scar tissue formed consequent to the occurrence of repeated small foci of tumor necrosis. The association of Hodgkin's disease and multiple malignancies is also discussed.

Radiologic Features, Staging, and Operability of Primary Lung Cancer in the Western Cape, South Africa: A 1-Year Retrospective Study

“…It has been suggested that fibrosis may occur as a desmoplastic reaction to an already existing carcinoma similar to that occurring in breast carci-noma. [27][28][29][30] On the other hand, it has recently been shown in experimental studies that chronic tuberculosis infection induces cell dysplasia and squamous cell carcinoma in a lungspecific way. 31 In a retrospective autopsy study of 82 lung cancer cases associated with a scar, Auerbach et al 7 documented 23% being associated with tuberculosis.…”

Collagens in scar carcinoma of the lung

“…3 4 Others, however, have reported that the carcinoma-related scar is an example of desmoplastic reaction such as is seen in breast, stomach, pancreas, and colon cancers. [5][6][7] It is generally agreed the pulmonary adenocarcinoma has a lower survival rate than squamous cell carcinoma, because the tumor often invades both lymphatic channels and blood vessels at a very early stage in its development7 8 and also produces symptoms later in the course of the disease. Therefore, it becomes worthwhile to investigate the origin and significance of the fibrosing process associated with pulmonary scar carcinoma.…”