Multiple rapid-responsive probes for hypochlorite detection based on dioxetane luminophore derivatives

Sun, Yingai; Gao, Yuqi; Tang, Chunchao; Dong, Gaopan; Zhao, Pei; Peng, Dunquan; Wang, Tiantian; Du, Lüpei; Li, Minyong

doi:10.1016/j.jpha.2021.10.001

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…As an ICT (Intramolecular Charge Transfer)-based fluorescent dye, 4 -hydroxybiphenyl-4-carbonitrile (dye 2) has many desirable features, which are attributed to its great pushpull electronic system, such as emission in the cyan spectral region and good photostabilities [33]. In addition, the N, N-dimethylthiocarbamate group has been widely used as a specific response site for ClO − [34][35][36][37]. Based on the above excellent photophysical properties, in this work, we design a new cyan fluorescence probe 1, which was composed of the ICT-based fluorophore, 4 -hydroxybiphenyl-4-carbonitrile and N, Ndimethylthiocarbamate group for the selectivity detection of ClO − .…”

Section: Introductionmentioning

confidence: 99%

A Simple ICT-Based Fluorescent Probe for HOCl and Bioimaging Applications

Zheng

Bing

et al. 2023

Biosensors

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Over the past few decades, drug-induced liver damage (DILI) has become a serious public health problem due to drug abuse. Among multifarious reactive oxygen species, mounting evidence attests that ClO− has been used as a potential biomarker in DILI. In this work, a new “turn-on” fluorescent probe 1 was designed and synthesized by modifying 4′-hydroxybiphenyl-4-carbonitrile (dye 2) with N, N-dimethylthiocarbamate as a response site for detecting ClO−. Probe 1 displayed a low detection limit (72 nM), fast response time (30 s), wide pH operating range (6–8), great tissue penetration, large Stokes shift (125 nm) and 291-fold fluorescence enhancement at 475 nm in the mapping of ClO−. Probe 1 could trace amounts of exogenous and endogenous ClO− with high sensitivity in MCF-7 cells and HeLa cells. Expectantly, the fluoxetine-induced liver injury model is successfully established, and probe 1 has been used for detecting the fluctuation of ClO− levels in the mouse model of fluoxetine-induced liver injury. All in all, probe 1 with its high specificity, good biological compatibility and liver tissue penetration ability is expected to assist with the early diagnosis of DILI and the clinical screening of various new drugs. We expect that probe 1 could be efficiently used as a powerful molecular tool to predict clinical DILI and explore molecular mechanisms between molecules and disease.

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Section: Introductionmentioning

confidence: 99%

A Simple ICT-Based Fluorescent Probe for HOCl and Bioimaging Applications

Zheng

Bing

et al. 2023

Biosensors

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“…Hypochlorite anion (ClO − ) plays an essential role in biological organisms and environmental monitors, which not only is produced by H 2 O 2 and chloride ions in activated neutrophils [ 1 , 2 , 3 , 4 , 5 ] but is also a kind of disinfector which can kill the coronavirus [ 6 , 7 , 8 ]. However, excessive hypochlorite could lead to diseases and even cancer including cardiovascular diseases, neuron degeneration, and arthritis [ 9 , 10 ]. Therefore, quantitative detection of hypochlorite with highly sensitive and selective methods becomes more and more crucial.…”

Section: Introductionmentioning

confidence: 99%

A Flexible Chemosensor Based on Colorimetric and Fluorescent Dual Modes for Rapid and Sensitive Detection of Hypochlorite Anion

Tao

Zhao

et al. 2021

Sensors

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A flexible chemosensor has been developed based on colorimetric and fluorescent dual modes using tetraphenylethylene-centered tetraaniline (TPE4A) for rapid and sensitive detection of hypochlorite anion. The fluorescent probe TPE4A exhibits a unique aggregation-induced emission (AIE) character which is proved by a blue shift of the fluorescent peak from 544 to 474 nm with the water equivalents increasing. With the addition of hypochlorite in solution, the absorbance of the probe changes and the responding fluorescence color can be observed to change from light green to purple. The detection limit of hypochlorite is 1.80 × 10−4 M in solution, and the visual detection limit is 1.27 µg/cm2 with the naked eye for the flexible paper-based chemosensor. The proposed flexible chemosensors show a good selectivity and sensitivity which has great potential for effective detection of hypochlorite anions without any spectroscopic instrumentation.

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