Multiple receptors converge on H2‐Q10 to regulate NK and γδT‐cell development

Goodall, Katharine J.; Nguyen, Angela; Matsumoto, Aya; McMullen, Julie R.; Eckle, Sidonia B G; Bertolino, Patrick; Sullivan, Lucy C.; Andrews, Daniel M.

doi:10.1111/imcb.12222

Cited by 13 publications

(23 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hepatocyte-derived H2-Q10, a ligand for CD8αα, also controls liver-resident γδ T cell development. 63 These programmed tissueresident γδ T cells would be shaped by and adapted to the tissue environment.…”

Section: Innate Lymphoid Cells (Ilcs)mentioning

confidence: 99%

Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer

Chen

Tian

2020

Cell Mol Immunol

View full text Add to dashboard Cite

The liver is a lymphoid organ with unique immunological properties, particularly, its predominant innate immune system. The balance between immune tolerance and immune activity is critical to liver physiological functions and is responsible for the sensitivity of this organ to numerous diseases, including hepatotropic virus infection, alcoholic liver disease, nonalcoholic fatty liver disease, autoimmune liver disease, and liver cancer, which are major health problems globally. In the past decade, with the discovery of liver-resident natural killer cells, the importance of innate lymphocytes with tissue residency has gradually become the focus of research. In this review, we address the current knowledge regarding hepatic innate lymphocytes with unique characteristics, including NK cells, ILC1/2/3s, NKT cells, γδ T cells, and MAIT cells, and their potential roles in liver homeostasis maintenance and the progression of liver diseases and cancer. A better understanding of the immunopathogenesis of hepatic innate lymphocytes will be helpful for proposing effective treatments for liver diseases and cancer.

show abstract

Section: Innate Lymphoid Cells (Ilcs)mentioning

confidence: 99%

Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer

Chen

Tian

2020

Cell Mol Immunol

View full text Add to dashboard Cite

show abstract

“…Thus far, at least two subsets of liver-resident γδ T cells have been identified: one CD1d-expressing subset that produces IL-17 governed by lipid antigens from gut commensal bacteria, 58 and another CD8αα + subset regulated by the MHC class I-related molecule, H2-Q10. 59 Similar populations of resident cells are also found in human livers, characterized by the expression of Vδ1 as well as established resident markers, such as CD69, CXCR3, and CXCR6. 3 However, the original source of γδ T liver cells in humans or mice is currently unknown.…”

Section: De Velopment Of Circul Ating and G Ut-re S Ident γδ T Cell Smentioning

confidence: 78%

“…The origin of mouse liver‐resident and gut‐resident γδ T cells—whose functions will obviously be important in primary CRC and liver metastasis—is somewhat unclear. Thus far, at least two subsets of liver‐resident γδ T cells have been identified: one CD1d‐expressing subset that produces IL‐17 governed by lipid antigens from gut commensal bacteria, 58 and another CD8αα + subset regulated by the MHC class I–related molecule, H2‐Q10 59 . Similar populations of resident cells are also found in human livers, characterized by the expression of Vδ1 as well as established resident markers, such as CD69, CXCR3, and CXCR6 3 .…”

Section: Development Of Circulating and Gut‐resident γδ T Cellsmentioning

confidence: 99%

Gut γδ T cells as guardians, disruptors, and instigators of cancer

Suzuki

Hayman

Kilbey

et al. 2020

Immunological Reviews

View full text Add to dashboard Cite

One of the most prevalent immune cell populations in gut tissue are γδ T cells. γδ T cells represent a collection of diverse subsets with independent phenotypes and functions-some subsets reside in tissue-resident and other subsets circulate in blood. In humans, these subsets are defined by their expression of the δ chain (Vδ1, Vδ2, and Vδ3), whereas γδ T cell subsets in mice are characterized by the expression of the γ chain (Vγ1, Vγ4, Vγ5, Vγ6, and Vγ7). One interesting aspect of γδ T cells is that the γδTCR often dictates where the cells localize anatomically. Human Vδ1 and Vδ3 cells are frequently found in organs, including the gut, skin, and liver, 1-3 while Vδ2 cells circulate in the peripheral blood. Similarly, mouse Vγ5, Vγ6, and Vγ7 cells are tissue-resident, whereas Vγ1 and Vγ4 cells traffic from tissue to lymph nodes. Human Vγ4Vδ1 cells and mouse Vγ7 cells account for the majority of gut-resident γδ T cells, 1,4 but other subsets can infiltrate diseased, damaged, and dysplastic gut

show abstract

“…Additionally, the CD8αα γδ T cells exist and are liver-resident cells. CD8αα binds to the class 1 MHC molecule H2-Q10 expressed on hepatocytes and thereby controls their activation and development [ 75 ]. In conclusion, γδ T cells are another liver-resident T cell subpopulation that support T RM cell function in the course of pathogen infection.…”

Section: Liver T Rm Cells—in Health Disease Anmentioning

confidence: 99%

Tissue-Resident Memory T Cells in the Liver—Unique Characteristics of Local Specialists

Bartsch

Damasio

Subudhi

et al. 2020

Cells

View full text Add to dashboard Cite

T cells play an important role to build up an effective immune response and are essential in the eradication of pathogens. To establish a long-lasting protection even after a re-challenge with the same pathogen, some T cells differentiate into memory T cells. Recently, a certain subpopulation of memory T cells at different tissue-sites of infection was detected—tissue-resident memory T cells (TRM cells). These cells can patrol in the tissue in order to encounter their cognate antigen to establish an effective protection against secondary infection. The liver as an immunogenic organ is exposed to a variety of pathogens entering the liver through the systemic blood circulation or via the portal vein from the gut. It could be shown that intrahepatic TRM cells can reside within the liver tissue for several years. Interestingly, hepatic TRM cell differentiation requires a distinct cytokine milieu. In addition, TRM cells express specific surface markers and transcription factors, which allow their identification delimited from their circulating counterparts. It could be demonstrated that liver TRM cells play a particular role in many liver diseases such as hepatitis B and C infection, non-alcoholic fatty liver disease and even play a role in the development of hepatocellular carcinoma and in building long-lasting immune responses after vaccination. A better understanding of intrahepatic TRM cells is critical to understand the pathophysiology of many liver diseases and to identify new potential drug targets for the development of novel treatment strategies.

show abstract

Multiple receptors converge on H2‐Q10 to regulate NK and γδT‐cell development

Cited by 13 publications

References 55 publications

Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer

Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer

Gut γδ T cells as guardians, disruptors, and instigators of cancer

Tissue-Resident Memory T Cells in the Liver—Unique Characteristics of Local Specialists

Contact Info

Product

Resources

About