Energy consumption is one of the most concerned topics of the industry, and the cost of energy represents a large proportion of operating expenditure for energy-intensive sectors. In the analysis and design of industrial processes, mainly thermodynamics is often used with economic principles to obtain the optimum design for energy-efficient systems. The performance of the system can be analyzed via applying the conservation principles of energy that is defined by the first law of thermodynamics. However, only regarding the conservation of energy is not sufficient to determine the real performance of the system. At this point, an exergy analysis is done to predict the useful part of the energy, also to provide the magnitudes and places of the irreversibilities and losses within the system. Moreover, the thermoeconomic analysis is done for providing useful information to design and operate a cost-effective system. In this study, thermoeconomic analysis of the steam boilers in a power plant was performed. The simulations of the steam boilers were done by using the Aspen HYSYS simulation software. The mass, energy and cost balance equations were obtained for the boilers to determine the effect of various fuels on the process economics.