This article addresses the global issue of preserving cultural heritage, which is associated, among other things, with the lack of provision for boundaries of protection zones for cultural heritage sites. This paper analyzes the worldwide experience in the field of establishing protection zones for cultural heritage sites, identifies the issues of preserving cultural heritage in Russia, as well as imperfections in the management of lands containing cultural heritage sites. To improve the management of such lands, a method of historical and cultural assessment of territories has been developed, which, on the basis of evaluative factors, makes it possible to characterize the historical and cultural value of a territory. In this article, based on this list of factors, a method for mathematical substantiation of the boundaries of protection zones of cultural heritage sites has been developed; this method includes seven stages. Using mathematical and statistical methods, models were obtained to determine the area of the protection (buffer) zone and the development control zone, the analysis of which revealed differentiation between the factors of historical and cultural assessment that characterize the urban environment, depending on the type of zones. The interpretation of the obtained models and the fields of their use are given.