Multiple, relapsing thrombosis in a young man with primary thrombocytosis

Ml, Randi; Fabris, Fabrizio; Stocco, Fabio; Tison, Tiziana; Girolami, A

doi:10.1097/00001721-199008000-00011

Cited by 5 publications

(2 citation statements)

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“…In 1 report, autopsy of a patient with essential thrombocytosis revealed myocardial infarction and pulmonary embolism. 14 This case suggests that young patients with primary thrombocytosis should be treated with antiplatelet agents in spite of the ab-sence of other thrombotic risks. In morphologically and cytogenetically defined essential thrombocythemia, the delayed development of either acute leukemia or myelofibrosis is unusual.…”

Section: Prognosismentioning

confidence: 91%

“…In addition to routine management of myocardial infarction there are cases reported where patients have undergone angioplasty or coronary artery bypass surgery. 14,15 Although no large-scale controlled trials exist, the consensus is to treat patients with essential thrombocythemia who have thrombotic events and cardiovascular risk factors. 4 The anticipated reduction in risk of future thrombosis should outweigh the risk of complications from drug therapy.…”

Section: Managementmentioning

confidence: 99%

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Essential Thrombocythemia-Related Acute ST-Segment Elevation Myocardial Infarction

et al. 2004

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Essential thrombocythemia is a clonal disorder of the myeloid stem cell that causes pathologic expansion of the megakaryocytic elements in the bone marrow, with a persistent increase in the platelet count. The disease is associated with an elevated risk of thrombosis, hemorrhage, and vasomotor symptoms. The presenting features of essential thrombocythemia can range from being asymptomatic to thrombohemorrhagic complications including acute myocardial infarction. Acute ST-segment elevation myocardial infarction due to left main trunk and ostial left anterior descending coronary artery lesions was diagnosed in a young 31-year-old man. Platelet count was markedly increased and essential thrombocythemia was also diagnosed. Because of left main disease, primary coronary intervention was not feasible and an emergent coronary artery bypass grafting was performed along with pharmacologic management of essential thrombocythemia. The early postoperative period was complicated by acute pulmonary embolism. Hydroxyurea and anagrelide were administered postoperatively, resulting in the decrease of platelet count. A succinct review of myocardial infarction in patients with essential thrombocythemia is presented, and therapeutic strategies in such patients are discussed.

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Section: Prognosismentioning

confidence: 91%

Section: Managementmentioning

confidence: 99%