Multiple retention deficit in passive avoidance in rats is eliminated by suprachiasmatic lesions

Stephan, Friedrich K.; Kovaćević, N

doi:10.1016/s0091-6773(78)92565-8

Cited by 86 publications

(56 citation statements)

References 13 publications

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“…In that study, test scores were optimal 24 h after training, but were significantly reduced at 18 or 30 h after training. As expected, this rhythm in performance was eliminated in SCN-lesioned rats, but surprisingly, these animals performed as well at all three time points as did control animals at the 24-h interval (52). In other studies, SCN-lesioned rats learned a T-maze discrimination task faster than intact animals (53) and no learning deficits were found in SCNlesioned golden hamsters on a conditioned place preference task where time of day was used as the discriminative stimulus (54).…”

Section: Lack Of Object Recognition Memory In Arrhythmic Hamsters: Losupporting

confidence: 77%

“…The few studies that have examined learning in SCN-lesioned animals support this idea. Intact rats exhibit a pronounced circadian rhythm in performance on a passive avoidance learning task (52). In that study, test scores were optimal 24 h after training, but were significantly reduced at 18 or 30 h after training.…”

Section: Lack Of Object Recognition Memory In Arrhythmic Hamsters: Lomentioning

confidence: 77%

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Hippocampal-dependent learning requires a functional circadian system

Ruby

Hwang²,

Wessells³

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

206

219

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Decades of studies have shown that eliminating circadian rhythms of mammals does not compromise their health or longevity in the laboratory in any obvious way. These observations have raised questions about the functional significance of the mammalian circadian system, but have been difficult to address for lack of an appropriate animal model. Surgical ablation of the suprachiasmatic nucleus (SCN) and clock gene knockouts eliminate rhythms, but also damage adjacent brain regions or cause developmental effects that may impair cognitive or other physiological functions. We developed a method that avoids these problems and eliminates rhythms by noninvasive means in Siberian hamsters (Phodopus sungorus). The present study evaluated cognitive function in arrhythmic animals by using a hippocampal-dependent learning task. Control hamsters exhibited normal circadian modulation of performance in a delayed novel-object recognition task. By contrast, arrhythmic animals could not discriminate a novel object from a familiar one only 20 or 60 min after training. Memory performance was not related to prior sleep history as sleep manipulations had no effect on performance. The GABA antagonist pentylenetetrazol restored learning without restoring circadian rhythms. We conclude that the circadian system is involved in memory function in a manner that is independent of sleep. Circadian influence on learning may be exerted via cyclic GABA output from the SCN to target sites involved in learning. Arrhythmic hamsters may have failed to perform this task because of chronic inhibitory signaling from the SCN that interfered with the plastic mechanisms that encode learning in the hippocampus.GABA ͉ hippocampus ͉ memory ͉ sleep ͉ suprachiasmatic nucleus

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Section: Lack Of Object Recognition Memory In Arrhythmic Hamsters: Losupporting

confidence: 77%

Section: Lack Of Object Recognition Memory In Arrhythmic Hamsters: Lomentioning

confidence: 77%

Hippocampal-dependent learning requires a functional circadian system

Ruby

Hwang²,

Wessells³

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

206

219

View full text Add to dashboard Cite

show abstract

“…Phase shifting the light-dark cycle also impaired passive (Tapp and Holloway, 1981;Fekete et al, 1985) and active (Fekete et al, 1985) avoidance memory. This 24 h rhythm performance was abolished after destruction of the SCN (Stephan and Kovacevic, 1978). Acquisition of a shuttle avoidance task and 8-arm radial mazes were better in animals during the dark period (Pagano and Lovely, 1972;Hauber and Bareiss, 2001).…”

Section: Discussionmentioning

confidence: 91%

mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning

et al. 2005

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Summary. Learning and memory, like most physiological processes, seem to be under the control of circadian rhythm. The recently cloned mPer1 and mPer2 genes play an important role in the regulation of the circadian rhythm. In this study, we tested mPer1 and mPer2 mutant mice in two different learning and memory paradigms, a water-maze place navigation task and contextual fear conditioning. In both learning tests, the hippocampus is critically involved. None of these learning types were affected by the mutations, suggesting that mPer1 and mPer2 do not play a major role in the regulation of hippocampusdependent learning and memory.

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“…For example, circadian phase shifting following training interferes with the retention of the hippocampusdependent Morris water maze task (Devan et al 2001) and also causes retrograde amnesia for hippocampus-dependent passive avoidance memory (Tapp and Holloway 1981). Furthermore, lesions of the suprachiasmatic nucleus (SCN) decrease hippocampus-dependent LTM in rodents (Stephan and Kovacevic 1978). Aplysia also undergo circadian oscillations in long-term sensitization (Fernandez et al 2003).…”

Section: Role Of Camentioning

confidence: 99%

Role of signal transduction crosstalk between adenylyl cyclase and MAP kinase in hippocampus-dependent memory

Xia

Storm

2012

Learn. Mem.

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One of the intriguing questions in neurobiology is how long-term memory (LTM) traces are established and maintained in the brain. Memory can be divided into at least two temporally and mechanistically distinct forms. Short-term memory (STM) lasts no longer than several hours, while LTM persists for days or longer. A crucial step in the generation of LTM is consolidation, a process in which STM is converted to LTM. Hippocampus-dependent LTM depends on activation of Ca 2+ , Erk/MAP kinase (MAPK), and cAMP signaling pathways, as well as de novo gene expression and translation. One of the transcriptional pathways strongly implicated in LTM is the CREB/CRE (calcium, cAMP response element) transcriptional pathway. Interestingly, this transcriptional pathway may also contribute to other forms of neuroplasticity including adaptive responses to drugs. Evidence discussed in this review indicates that activation of the Erk1/2 MAP Kinase (MAPK)/ CRE transcriptional pathway during the formation of hippocampus-dependent memory depends on calmodulin (CaM)-stimulated adenylyl cyclases.

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Multiple retention deficit in passive avoidance in rats is eliminated by suprachiasmatic lesions

Cited by 86 publications

References 13 publications

Hippocampal-dependent learning requires a functional circadian system

Hippocampal-dependent learning requires a functional circadian system

mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning

Role of signal transduction crosstalk between adenylyl cyclase and MAP kinase in hippocampus-dependent memory

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