Multiple Roles of CD4 and CD8 in T Cell Activation

Koretzky, Gary A.

doi:10.4049/jimmunol.1090076

Cited by 57 publications

(58 citation statements)

References 23 publications

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“…The T lymphocyte subset plays a vital role in cellular immune response [31]. The proportions of CD4 + and CD8 + T lymphocyte subset are important indexes for T lymphocyte immune function.…”

Section: Discussionmentioning

confidence: 99%

“…T lymphocytes are mainly responsible for cellular immunity and B lymphocytes are for humoral immune. Inadequate proliferation is an indicator of immunosuppression [31]. Wiegers et al found that above physiological concentration of Cort suppressed ConAinduced peripheral blood T lymphocyte proliferation of rats in vivo and in vitro, whereas below physiological concentration of Cort stimulated that [32].…”

Section: Discussionmentioning

confidence: 99%

“…CD4 + T lymphocytes can recognize foreign antigens to mediate immune response, which affect the immunocyte activation. CD8 + T lymphocytes are mainly cytotoxic T lymphocyte, which can kill all the target cells [31,33,34]. Decreased CD4 + and CD8 + T lymphocyte subsets reflect the immunosuppression status [35].…”

Section: Discussionmentioning

confidence: 99%

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Effects of Corticosterone on Immune Functions of Cultured Rat Splenic Lymphocytes Exposed to Aluminum Trichloride

Yang

Zhuang

et al. 2016

Biol Trace Elem Res

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Aluminum (Al) exposure is toxic to immune system. Studies have implicated that glucocorticoids (GCs) exert the dual regulation effect on the immune function depending on the concentration. However, it is unknown whether a dual effect of GCs exists in the AlCl3-treated lymphocytes. Corticosterone (Cort) is one kind of GCs. To investigate the effect of different concentration Cort on AlCl3-treated lymphocytes, rat splenic lymphocyte was isolated and cultured with 0.55 mmol/L AlCl3, simultaneously administrated Cort at final concentration of 0 (control group, CG), 10(-8) (low-level group, LG), and 10(-6) (high-level group, HG) mol/L, respectively. Another group without AlCl3 and Cort served as the blank group (BG). We found that low concentration Cort increased the T and B lymphocyte proliferation rate, proportions of CD4(+) T lymphocyte subset, IgG, IL-2, and TNF-α contents, whereas high concentration Cort decreased those in AlCl3-treated lymphocytes. In conclusion, the results of this study indicated that low concentration Cort relieves the immunotoxicity of AlCl3 on the splenic lymphocytes, whereas high concentration Cort aggravates it.

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“…The T lymphocyte subset plays a vital role in cellular immune response [31]. The proportions of CD4 + and CD8 + T lymphocyte subset are important indexes for T lymphocyte immune function.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Corticosterone on Immune Functions of Cultured Rat Splenic Lymphocytes Exposed to Aluminum Trichloride

Yang

Zhuang

et al. 2016

Biol Trace Elem Res

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“…This mis-pairing hypothesis was modeled in mice with the ovalbumin-specific αβ TCR OT-I, which resulted in re-directed specificity of murine γδ T cells toward ovalbumin peptide, but whether or not the TCRs were actually mis-paired was not reported (89). Vγ2Vδ2 cells have been expanded with 2M3B1PP and infected with γ-retrovirus to transduce TCRαβ chains with specificity toward MAGE-A4 peptide, but co-transduction with CD8 was required in order to transfer significant MHC Class-I-restricted recognition of MAGE-A4 peptide-pulsed tumor cells (90,91). Similar studies have transferred αβ TCRs specific for CMV pp65 peptide or minor histocompatibility antigens into γδ T cells rendering them reactive to antigen-appropriate tumor cells (92).…”

Section: Genetic Modification Of γδ T Cells For Therapeutic Usementioning

confidence: 99%

Innovative T Cell-Targeted Therapy for Ovarian Cancer

Cooper¹

2014

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“…The adaptive immune system is composed of multiple, functionally distinct cell types, including CD3+CD4+CD8− and CD3+CD4−CD8+ lymphocytes [3]. The cellular subpopulations express the common lymphocyte antigen CD45 on their cell surface.…”

Section: Introductionmentioning

confidence: 99%

Memory AND effector cells in children with bacterial infections of the gastrointestinal and respiratory tracts

Palacios-Martínez¹,

González-Torres²,

Rodríguez-Cruz³

et al. 2012

OJI

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Infections in infants and children under five years of age are a public health in México and are one of the major causes of death. Methods In this study, lymphocyte immunophenotyping for CD3+ (T-cells), CD3+CD4+, CD3+CD8+, CD3+CD19+, CD3+CD16/56+, CD45RA+, CD45RO+, CD62L− and CD28− were determined in the whole blood of gastrointestinal and respiratory bacterial infected children, using a fourcolor flow cytometry technique. Results: Our data showed that the percentages and the absolute numbers of monocytes and granulocytes are increased in infected children, when compared to the control group. Similarly, we observed increases in the percentages of B lymphocytes, CD8+ cells, memory T cells (CD4+CD45RO+ and CD8+CD45RO+) and effector lymphocytes (CD4+CD62L− and CD8+CD28−) in infected children compared with the control group. In contrast, naive T cells were decreased in the bacterial infected children relative to the control group. Additionally, we used ELISA assays to identify the pathogen agent in gastrointestinal and respiratory infection.

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Multiple Roles of CD4 and CD8 in T Cell Activation

Cited by 57 publications

References 23 publications

Effects of Corticosterone on Immune Functions of Cultured Rat Splenic Lymphocytes Exposed to Aluminum Trichloride

Effects of Corticosterone on Immune Functions of Cultured Rat Splenic Lymphocytes Exposed to Aluminum Trichloride

Innovative T Cell-Targeted Therapy for Ovarian Cancer

Memory AND effector cells in children with bacterial infections of the gastrointestinal and respiratory tracts

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