Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: Implications on lung carcinogenesis

Assessment of relationship between tobacco consumption and laryngopharyngeal cancers

“…[15][16][17][18][19] Nicotine is non-carcinogenic, but in vitro and animal studies have proved that nicotine plays a role in tumor promotion through angiogenesis and inhibition of apoptosis. [20,21] In the present study, nicotine levels were detected only in less number of samples by TLC method. Analysis by GC method showed that there is more percentage of blood nicotine levels (>1.425 ug/ml) in 55% cases of cancer group, alarming a possibility to acquire laryngopharyngeal cancer if there is prolonged consumption of tobacco.…”

Does Beta-blocker Therapy Improve the Survival of Patients with Metastatic Non-small Cell Lung Cancer?

“…Nicotine and its derivatives play important roles in the stimulation of NSCLC growth (Catassi et al, 2008;. In this regard, nicotinic acetylcholine receptors (nAChRs), beta-ARs (Schuller et al, 1999) and the activation of the betaadrenergic signaling cascade (Schuller et al, 1999;Laag et al, 2006) and the Akt pathway (Carlisle et al, 2007) are important, as shown in many animal studies (Schuller and Orloff, 1998;Schuller et al, 2000;West et al, 2004;Arredonda et al, 2006;Schuller, 2008;2009).…”

“…Nicotine causes a deficiency in GABA, an antagonist of betaadrenergic signalling . nAChRs are important for the autocrine-proliferative network that facilitates the growth of neoplastic cells (Catassi et al, 2008;. Regarding the intensity of the adrenergic and muscarinic cholinergic receptors in lung cancer tissue versus normal lung parenchyma, a study showed that beta-ARs were decreased, whereas muscarine receptors were increased in pulmonary adenocarcinoma (Kondratenko et al, 1991).…”

Effects of Different Phases of Cigarette Smoke on Lipid Peroxidation and Membrane Structure in Liposomes

“…It comes as no surprise that the development of pathogenic oxidative processes in human organism is lifestyle dependent. [2] Thus, cigarette smoking, which is considered in the literature as a risk factor for various pathological developments and diseases (such as chronic bronchitis, emphysema, cardiovascular disease, carcinogenic developments, and tumour growth [7][8][9][10][11][12][13][14] ) causes, in particular, the oxidative damage of cell membranes and biological macromolecules. [6,[15][16][17][18][19][20][21][22][23] Cigarette smoke is a complex chemical conglomerate that contains high concentrations of two distinctly different fractions of free radicals, one in its gas phase (GP) and another one in the particulate matter (tar).…”