Multiple roles of the prostaglandin D2 signaling pathway in reproduction

Rossitto, Moïra; Ujjan, Safdar Ali; Poulat, Françis; Boizet-Bonhoure, Brigitte

doi:10.1530/rep-14-0381

Cited by 48 publications

(36 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the “Mediterranean” pattern, there was a notably high intake of vegetable oils that were rich in omega‐6 PUFA, including linoleic acids. Linoleic acids are the precursors of prostaglandins, which are involved in follicle development, corpus luteum function, and embryo implantation . Moreover, high adherence to the “Mediterranean” pattern was positively associated with vitamin B 6 in the blood and follicular fluid, in addition to red blood cell folate.…”

Section: Discussionmentioning

confidence: 99%

Lack of a meaningful association between dietary patterns and in vitro fertilization outcome among Japanese women

Sugawa¹,

Okubo

Sasaki

et al. 2018

Reprod Medicine & Biology

View full text Add to dashboard Cite

PurposeThe purpose of this study was to examine whether preconception maternal dietary pattern is associated with in vitro fertilization (IVF) outcome among Japanese women.MethodsThis prospective study included 140 Japanese women who underwent conventional‐IVF/intracytoplasmic sperm injection. The patients’ diets during the previous month before egg retrieval were assessed with validated brief‐type self‐administered diet history questionnaire. Dietary patterns from 33 predefined food groups [energy‐adjusted food (g/1000 kcal)] were extracted by factor analysis. The primary outcome measure was clinical pregnancy rate after IVF.ResultsThirty‐six women had confirmed clinical pregnancy. Three dietary patterns were identified: “Vegetable and seafood,” “Western,” and “Rice and miso soup.” The “Vegetables and seafood” dietary pattern (high intakes of green and other vegetables, mushrooms, seasoning, fish, soy products, chicken, and potatoes) was not associated with clinical pregnancy ([odds ratio per one‐quartile increase in dietary pattern: 0.94 (95% confidence interval: 0.67‐1.32), P = 0.73]. This relationship was unaltered after controlling for potential confounders. Furthermore, no association was seen between the other two dietary patterns and clinical pregnancy.ConclusionsThe three maternal preconception dietary patterns identified revealed no meaningful association with IVF outcome in Japanese women. Further studies in various populations with different dietary patterns are needed to confirm these findings.

show abstract

Section: Discussionmentioning

confidence: 99%

Lack of a meaningful association between dietary patterns and in vitro fertilization outcome among Japanese women

Sugawa¹,

Okubo

Sasaki

et al. 2018

Reprod Medicine & Biology

View full text Add to dashboard Cite

show abstract

“…It has been reported that paracetamol and some nonsteroidal antiinflammatory drugs (NSAIDs) such as aspirin and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent (Mazaud-Guittot et al 2013). Furthermore, PGD 2 influences male germ cell differentiation in the fetal mouse testis (Moniot et al 2014), and it has been proposed that the hematopoietic PGD 2 synthase participates in the SOX9 nuclear translocation necessary for the process of Sertoli cell differentiation (Rossitto et al 2015). PG receptors have been described in Leydig cells (i.e., EP1, DP, FP, TP, and PPARg receptors; Walch et al 2003, Frungieri et al 2006, Schell et al 2007, Kowalewski et al 2009, Pandey et al 2009), Sertoli cells (e.g., EP1, EP2, EP3, EP4, DP, IP, FP, and PPARg receptors; Ishikawa & Morris 2006, Winnal et al 2007, Kristensen et al 2011, Matzkin et al 2012a, and the seminiferous tubule wall (PPARg receptors; Frungieri et al 2002a).…”

Section: Cox and Pgs In The Human Testismentioning

confidence: 99%

Cyclooxygenase and prostaglandins in somatic cell populations of the testis

Frungieri¹,

Calandra²,

Mayerhofer³

et al. 2015

Reproduction

View full text Add to dashboard Cite

Prostaglandins (PGs) are synthesized through the action of the rate-limiting enzyme cyclooxygenase (COX) and further specific enzymes. The development of Cox-deficient mice in the 1990s gave insights into the reproductive roles of PGs. Female Cox-knockout mice were subfertile or infertile. Interestingly, fertility was not affected in male mice deficient in Cox, suggesting that PGs may not be critical for the functioning of the testis. However, this conclusion has recently been challenged by observations of important roles for PGs in both physiological and pathological processes in the testis. The two key somatic cell types in the testis, Leydig and Sertoli cells, express the inducible isoenzyme COX2 and produce PGs. Testicular COX2 expression in these somatic cells is regulated by hormonal input (FSH, prolactin (PRL), and testosterone) as well as by IL1b. PGs modulate steroidogenesis in Leydig cells and glucose uptake in Sertoli cells. Hence, the COX2/PG system in Leydig and Sertoli cells acts as a local modulator of testicular activity, and consequently may regulate spermatogenic efficiency. In addition to its expression in Leydig and Sertoli cells, COX2 has been detected in the seminiferous tubule wall, and in testicular macrophages and mast cells of infertile patients. These observations highlight the possible relevance of PGs in testicular inflammation associated with idiopathic infertility. Collectively, these data indicate that the COX2/PG system plays crucial roles not only in testicular physiology (i.e., development, steroidogenesis, and spermatogenesis), but more importantly in the pathogenesis or maintenance of infertility status in the male gonad. Further studies of these actions could lead to new therapeutic approaches to idiopathic male infertility.Free German abstract: A German translation of this abstract is freely available at

show abstract

“…Furthermore, expression of L-PGDS protein was present in E12.5 male gonads in both Sertoli and germ cells (Moniot et al . 2009) that it is regulated upstream through either COX1 (cyclooxygenase 1) or COX2 pathways (Rossitto et al 2015). However, neither male Cox2 - nor Cox1 - knockout mice are infertile; thus, there may be multiple ways to promote production of L-PGDS in order to have a sufficient quantity of PGD2 (Gerena et al .…”

Section: What Is the Origin Of The Sertoli Cell …A Cell That Is Thougmentioning

confidence: 99%

“…NR5A1 induces initial expression of Sox9 which is then upregulated by SRY and SOX9 (Sekido and Lovell-Badge 2008) and SOX9 not only upregulates FGF9 and PTGS but it also upregulates itself (DiTacchio et al 2012). A role of both PTGS and FGF9 is to continually provide sustained expression of SOX9 (Rossitto et al 2015) (Fig. 1).…”

Section: What Happens In Vivo When Vegfa Isoforms Are Eliminated In Smentioning

confidence: 99%

Vascular endothelial growth factor A: just one of multiple mechanisms for sex-specific vascular development within the testis?

Sargent¹,

McFee²,

Gomes³

et al. 2015

Journal of Endocrinology

View full text Add to dashboard Cite

Testis development from an indifferent gonad is a critical step in embryogenesis. A hallmark of testis differentiation is sex-specific vascularization which occurs as endothelial cells migrate from the adjacent mesonephros into the testis to surround Sertoli-germ cell aggregates and induce seminiferous cord formation. Many in vitro experiments have demonstrated that Vascular Endothelial Growth Factor A (VEGFA) is a critical regulator of this process. Both inhibitors to VEGFA signal transduction and excess VEGFA isoforms in testis organ cultures impaired vascular development and seminiferous cord formation. However, in vivo models using mice which selectively eliminated all VEGFA isoforms: in Sertoli and germ cells (pDmrt1-Cre;Vegfa−/−); Sertoli and Leydig cells (Amhr2-Cre;Vegfa−/−) or Sertoli cells (Amh-Cre;Vegfa−/− and Sry-Cre;Vegfa−/−) displayed testes with observably normal cords and vasculature at postnatal day 0 and onwards. Embryonic testis development may be delayed in these mice; however, the postnatal data indicate that VEGFA isoforms secreted from Sertoli, Leydig or germ cells are not required for testis morphogenesis within the mouse. A Vegfa signal transduction array was employed on postnatal testes from Sry-Cre;Vegfa−/− versus controls. Ptgs1 (Cox1) was the only upregulated gene (5-fold). COX1 stimulates angiogenesis and upregulates, VEGFA, Prostaglandin E2 (PGE2) and PGD2. Thus, other gene pathways may compensate for VEGFA loss, similar to multiple independent mechanisms to maintain SOX9 expression. Multiple independent mechanism that induce vascular development in the testis may contribute to and safeguard the sex-specific vasculature development responsible for inducing seminiferous cord formation, thus, ensuring appropriate testis morphogenesis in the male.

show abstract

Multiple roles of the prostaglandin D2 signaling pathway in reproduction

Cited by 48 publications

References 99 publications

Lack of a meaningful association between dietary patterns and in vitro fertilization outcome among Japanese women

Lack of a meaningful association between dietary patterns and in vitro fertilization outcome among Japanese women

Cyclooxygenase and prostaglandins in somatic cell populations of the testis

Vascular endothelial growth factor A: just one of multiple mechanisms for sex-specific vascular development within the testis?

Contact Info

Product

Resources

About