2022
DOI: 10.26434/chemrxiv-2022-q6pqt-v2
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Multiple Routes to Bicontinuous Cubic Liquid Crystal Phases Discovered by High-Throughput Self-Assembly Screening of Multi-Tail Lipidoids

Abstract: Bicontinuous cubic phases offer advantageous routes to a broad range of applied materials ranging from drug delivery devices to membranes. However, a priori design of molecules that assemble into these phases remains a technological challenge. In this article, high-throughput synthesis of lipidoids which undergo protonation-driven self-assembly (PrSA) into liquid crystalline phases is conducted. With this screening approach we discover 12 different multi-tail lipidoid structures capable of assembling into the … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
7
0

Year Published

2023
2023
2023
2023

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(7 citation statements)
references
References 70 publications
0
7
0
Order By: Relevance
“…Inverse hexagonal phases were observed in our earlier study in lipidoids protonated by either sulfuric or hydrochloric acids. 24 However, the phase was only previously seen for protonated lipidoids with non-linear tails and branched headgroups. In addition, such protonated lipidoids more readily formed the double gyroid phase, a cubic phase consists of interpenetrating 3D networks with low interfacial curvature relative to the hexagonal phase.…”
Section: Resultsmentioning
confidence: 92%
See 4 more Smart Citations
“…Inverse hexagonal phases were observed in our earlier study in lipidoids protonated by either sulfuric or hydrochloric acids. 24 However, the phase was only previously seen for protonated lipidoids with non-linear tails and branched headgroups. In addition, such protonated lipidoids more readily formed the double gyroid phase, a cubic phase consists of interpenetrating 3D networks with low interfacial curvature relative to the hexagonal phase.…”
Section: Resultsmentioning
confidence: 92%
“…25,26 In this study we focused on lipidoid structures with 3 or more amines per headgroup and 4 or more hydrophobic tails, following our previously optimized synthetic procedure. 23,24 Headgroups were selected from either linear, branched, or cyclic arrangements of amines with variable hydrocarbon spacer groups between the amines (Figure 1A). One gemini lipidoid was also prepared for comparison, using a primary diamine fully substituted with four tails.…”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations