Multiple scattering in optical coherence tomography II Experimental and theoretical investigation of cross talk in wide-field optical coherence tomography

Karamata, Boris; Leutenegger, Marcel; Laubscher, Markus; Bourquin, Stéphane; Lasser, Theo; Lambelet, Patrick

doi:10.1364/josaa.22.001380

Cited by 54 publications

(26 citation statements)

References 21 publications

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“…The whole subject has attracted wide interest in the last two decades particularly accelerated by the entrance of OCT, as a noninvasive powerful technique for biomedical imaging [17]. However, OCT has been considered so far basically as low temporal coherence interferometry and only recently was some attention dedicated to the importance of spatial coherence effects [32,40,41]. The high signal-to-noise ratios obtained by the different OCT techniques allowed imaging of scattering media such as tissue in spite of the very small signals available.…”

Section: Introductionmentioning

confidence: 99%

Spatial and temporal coherence effects in interference microscopy and full‐field optical coherence tomography

Abdulhalim

2012

Annalen der Physik

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Low‐coherence optical microscopy or optical coherence microscopy uses light with short coherence length. The well‐known case is: “white‐light interferometry”, which became recently more known as: “optical coherence tomography”. However, when lenses and microscope objectives are used to create interferometric images, in what is known classically as “interference microscopy” or today as “full‐field optical coherence tomography” the spatial coherence starts to play a critical role. In this article the coherence effects in low‐coherence optical microscopy are reviewed. As this technology is becoming increasingly publicized due to its importance in three‐dimensional imaging, particularly of scattering biological media and optical metrology, the understanding of the fundamental physics behind it is essential. The interplay between longitudinal spatial coherence and temporal coherence and the effects associated with them are discussed in detail particularly when high numerical apertures are used. An important conclusion of this study is that a high‐contrast, high‐resolution system for imaging of multilayered samples is the one that uses narrowband illumination and high‐NA objectives with an index‐matching fluid. Such a system, when combined with frequency‐domain operation, can reveal nearly real‐time three‐dimensional images, and is thus competitive with confocal microscopy.

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Section: Introductionmentioning

confidence: 99%

Spatial and temporal coherence effects in interference microscopy and full‐field optical coherence tomography

Abdulhalim

2012

Annalen der Physik

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“…Moreover, adaptive optics for aberration correction was coupled to OCT for better resolution of the retinal structure in B scans [46,47,49] and in C scans [48], and for correcting the wavefront in high-resolution 2 photon microscopy [50]. However Karamata et al demonstrated experimentally and explained in depth in [51][52][53] that coherent illumination is a source of crosstalks that may quickly degrade the image quality. Crosstalk does not appear with incoherent illumination.…”

Section: Spatially Coherent Vs Incoherent Sources: Advantages and Drmentioning

confidence: 99%

En face coherence microscopy [Invited]

Thouvenin¹,

Grieve²,

Xiao³

et al. 2017

Biomed. Opt. Express

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En face coherence microscopy or flying spot or full field optical coherence tomography or microscopy (FF-OCT/FF-OCM) belongs to the OCT family because the sectioning ability is mostly linked to the source coherence length. In this article we will focus our attention on the advantages and the drawbacks of the following approaches: en face versus B scan tomography in terms of resolution, coherent versus incoherent illumination and influence of aberrations, and scanning versus full field imaging. We then show some examples to illustrate the diverse applications of en face coherent microscopy and show that endogenous or exogenous contrasts can add valuable information to the standard morphological image. To conclude we discuss a few domains that appear promising for future development of en face coherence microscopy. tomography with a Linnik microscope," Appl. Opt. 41, 805-812 (2002). 6. L. Vabre, A. Dubois, and A. C. Boccara, "Thermal-light full-field optical coherence tomography," Opt. Lett. 27(7), 530-532 (2002). 7. Handbook of Full-Field Optical Coherence Microscopy: Technology and Applications; Arnaud Dubois editor.Pan Stanford 2016. 8. M. Akiba, K. P. Chan, and N. Tanno, "Full-field optical coherence tomography by two-dimensional heterodyne detection with a pair of CCD cameras," Opt. Lett. 28(10), 816-818 (2003). 9. L. Yu and M. Kim, "Full-color three-dimensional microscopy by wide-field optical coherence tomography," Opt.Express 12(26), 6632-6641 (2004 Hüttmann, "In-vivo retinal imaging with off-axis full-field time-domain optical coherence tomography," Opt. Lett. 41(21), 4987-4990 (2016). 44. M. Villiger, C. Pache, and T. Lasser, "Dark-field optical coherence microscopy," Opt. Lett. 35(20), 3489-3491 (2010). 45. E. Auksorius and A. C. Boccara, "Dark-field full-field optical coherence tomography," Opt. Lett. 40(14), 3272-3275 (2015 4948-4956 (2008). 107. C.-E. Leroux, F. Bertillot, O. Thouvenin, and A.-C. Boccara, "Intracellular dynamics measurements with full field optical coherence tomography suggest hindering effect of actomyosin contractility on organelle transport," Biomed. Opt. Express 7(11), 4501-4513 (2016). 108. J. Schmitt, "OCT elastography: imaging microscopic deformation and strain of tissue," Opt. Express 3(6), 199-211 (1998

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“…There is no correspondence between the arrival time t and the position of a scatterer. Thus, classical imaging fails in multiple scattering media [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Multiple scattering of ultrasound in weakly inhomogeneous media: Application to human soft tissues

Aubry

Derode

2011

The Journal of the Acoustical Society of America

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Waves scattered by a weakly inhomogeneous random medium contain a predominant single scattering contribution as well as a multiple scattering contribution which is usually neglected, especially for imaging purposes. A method based on random matrix theory is proposed to separate the single and multiple scattering contributions. The experimental set up uses an array of sources/receivers placed in front of the medium. The impulse responses between every couple of transducers are measured and form a matrix. Single-scattering contributions are shown to exhibit a deterministic coherence along the antidiagonals of the array response matrix, whatever the distribution of inhomogeneities. This property is taken advantage of to discriminate single from multiple-scattered waves. This allows one to evaluate the absorption losses and the scattering losses separately, by comparing the multiple scattering intensity with a radiative transfer model. Moreover, the relative contribution of multiple scattering in the backscattered wave can be estimated, which serves as a validity test for the Born approximation. Experimental results are presented with ultrasonic waves in the MHz range, on a synthetic sample (agar-gelatine gel) as well as on breast tissues. Interestingly, the multiple scattering contribution is found to be far from negligible in the breast around 4.3 MHz.

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Multiple scattering in optical coherence tomography II Experimental and theoretical investigation of cross talk in wide-field optical coherence tomography

Cited by 54 publications

References 21 publications

Spatial and temporal coherence effects in interference microscopy and full‐field optical coherence tomography

Spatial and temporal coherence effects in interference microscopy and full‐field optical coherence tomography

En face coherence microscopy [Invited]

Multiple scattering of ultrasound in weakly inhomogeneous media: Application to human soft tissues

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