2002
DOI: 10.1002/1521-4141(2002010)32:10<2737::aid-immu2737>3.0.co;2-0
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Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus

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Cited by 80 publications
(58 citation statements)
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“…However, conflicting results have been observed concerning MOG expression in human thymus. While MOG transcripts are found in purified mTEC [18] and in some but not all human thymus [20], Bruno et al [21] failed to detect MOG a and b isoforms in all human thymus tested. In C57BL/6 mice, Delarasse et al [7] have shown that MOG transcripts are expressed in thymus.…”
Section: Discussionmentioning
confidence: 95%
“…However, conflicting results have been observed concerning MOG expression in human thymus. While MOG transcripts are found in purified mTEC [18] and in some but not all human thymus [20], Bruno et al [21] failed to detect MOG a and b isoforms in all human thymus tested. In C57BL/6 mice, Delarasse et al [7] have shown that MOG transcripts are expressed in thymus.…”
Section: Discussionmentioning
confidence: 95%
“…Regarding immune privileged tissues, some proteins responsible for triggering the deletion of autoreactive T and B cells are not expressed in the central immune system, allowing autoreactive lymphocytes to escape from central selection. 142,143 Under normal physiological conditions, these autoreactive T and B cells are inactive because they are unable to enter immune privileged tissues; however, when immune privilege is disturbed, these autoreactive T and B cells may gain access to these tissues and cause an autoimmune response.…”
Section: Discussionmentioning
confidence: 99%
“…It is also important to notice that the MBP, PLP and MOG proteins could theoretically induce different levels of self tolerance [31]. Indeed, the MOG protein is only expressed in the central nervous system whereas MBP and PLP are also expressed in the thymus [32].…”
Section: Discussionmentioning
confidence: 99%