Multiple Sclerosis: Changes in Microarchitecture of White Matter Tracts after Training with a Video Game Balance Board

Prosperini, Luca; Fanelli, Fulvia; Petsas, Nikolaos; Sbardella, Emilia; Tona, Francesca; Raz, Eytan; Fortuna, Deborah; Angelis, Floriana De; Pozzilli, Carlo; Pantano, Patrizia

doi:10.1148/radiol.14140168

Cited by 97 publications

(112 citation statements)

References 38 publications

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“…51,52 Karim et al showed that playing exergames resulted in a robust hyperemic response in the superior temporal gryus and supramarginal gyrus, 51 indicating that these areas were important for balance. Furthermore, the duration of this response after cessation was prolonged (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) s longer than what would be expected), suggesting an adaptation of the vestibular network in response to the balance task.…”

Section: Participant's Experience Of Exergamingmentioning

confidence: 99%

“…Furthermore, the duration of this response after cessation was prolonged (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) s longer than what would be expected), suggesting an adaptation of the vestibular network in response to the balance task. After 12-weeks of Wii balance training, Prosperini et al showed an improvement in balance, 52 suggesting a functional restoration (i.e. activitydependent myelo-modulation in partially damaged pathways) of myelin sheaths on demyelinated axons.…”

Section: Participant's Experience Of Exergamingmentioning

confidence: 99%

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The use of gaming technology for rehabilitation in people with multiple sclerosis

Taylor

Griffin

2014

Mult Scler

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Gaming technology -exergaming -is a novel tool to facilitate exercise, improve balance, and encourage rehabilitation training. This review will describe some of the key exergame research to promote physical activity and its use in rehabilitation in other diseases or clinical populations. We will then describe the current state of research in exergaming in people with multiple sclerosis and describe the theories for the mechanism behind some of the improvements in outcomes seen after using exergaming. Lastly, we will identify gaps in the literature and provide directions for future work in this growing area. The current work is contradictory and there is no consensus with regards to training duration/intensity and the outcomes used to assess the clinical effectiveness. This in part is due to the off-the-shelf nature of the games used. A more satisfactory approach would be the development of bespoke games which match a clinical need. Exergames are seen as enjoyable and could be effective in enhancing adherence to rehabilitation. However, the definitive RCT has yet to be carried out comparing exergaming to traditional exercise.

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Section: Participant's Experience Of Exergamingmentioning

confidence: 99%

Section: Participant's Experience Of Exergamingmentioning

confidence: 99%

The use of gaming technology for rehabilitation in people with multiple sclerosis

Taylor

Griffin

2014

Mult Scler

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“…Moreover, environmental enrichment has been shown to preserve peristriatal cerebral volume in the R6/1 HD mouse model (van Dellen et al 2000). Motor and cognitive interventions have additionally been shown to increase hippocampal volume, white matter and gray matter volume as well as cortical thickness in the left middle frontal gyrus, inferior frontal gyrus, superior temporal gyrus in the elderly and those with other neurodegenerative disorders (Boyke et al 2008;Engvig et al 2010Engvig et al , 2012Erickson et al 2010Erickson et al , 2011L€ ovd en et al 2012;Burciu et al 2013;Bonzano et al 2014;Prosperini et al 2014;Sehm et al 2014). These findings provide evidence to suggest that lifestyle factors play an important role in modulating the pathology and clinical profile of HD.…”

Section: Discussionmentioning

confidence: 99%

The effect of multidisciplinary rehabilitation on brain structure and cognition in Huntington's disease: an exploratory study

Cruickshank

Thompson

et al. 2015

Brain and Behavior

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BackgroundThere is a wealth of evidence detailing gray matter degeneration and loss of cognitive function over time in individuals with Huntington's disease (HD). Efforts to attenuate disease-related brain and cognitive changes have been unsuccessful to date. Multidisciplinary rehabilitation, comprising motor and cognitive intervention, has been shown to positively impact on functional capacity, depression, quality of life and some aspects of cognition in individuals with HD. This exploratory study aimed to evaluate, for the first time, whether multidisciplinary rehabilitation can slow further deterioration of disease-related brain changes and related cognitive deficits in individuals with manifest HD.MethodsFifteen participants who manifest HD undertook a multidisciplinary rehabilitation intervention spanning 9 months. The intervention consisted of once-weekly supervised clinical exercise, thrice-weekly self-directed home based exercise and fortnightly occupational therapy. Participants were assessed using MR imaging and validated cognitive measures at baseline and after 9 months.ResultsParticipants displayed significantly increased gray matter volume in the right caudate and bilaterally in the dorsolateral prefrontal cortex after 9 months of multidisciplinary rehabilitation. Volumetric increases in gray matter were accompanied by significant improvements in verbal learning and memory (Hopkins Verbal Learning-Test). A significant association was found between gray matter volume increases in the dorsolateral prefrontal cortex and performance on verbal learning and memory.ConclusionsThis study provides preliminary evidence that multidisciplinary rehabilitation positively impacts on gray matter changes and cognitive functions relating to verbal learning and memory in individuals with manifest HD. Larger controlled trials are required to confirm these preliminary findings.

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“…Patients showed improvement of diffusion tensor imaging measures of superior cerebellar peduncles. Accordingly, there was also a clinical improvement of static balance [64].…”

Section: Pappalardo Et Al Mult Scler and Demyelinating Dismentioning

confidence: 84%

Neurorehabilitation in Persons with Multiple Sclerosis: Scientific Basis and Options of Treatment

Pappalardo¹,

Amico²,

Chisari³

2016

J Mult Scler

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Multiple Sclerosis: Changes in Microarchitecture of White Matter Tracts after Training with a Video Game Balance Board

Cited by 97 publications

References 38 publications

The use of gaming technology for rehabilitation in people with multiple sclerosis

The use of gaming technology for rehabilitation in people with multiple sclerosis

The effect of multidisciplinary rehabilitation on brain structure and cognition in Huntington's disease: an exploratory study

Neurorehabilitation in Persons with Multiple Sclerosis: Scientific Basis and Options of Treatment

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