The nature and unpredictable prognosis of multiple sclerosis (MS) make pregnancy and motherhood challenging experiences for women with the disease. Using the thematic synthesis method, we aimed to systematically interpret and synthesize data from qualitative research examining the motherhood experiences of women with MS. The analyses revealed three analytical themes: “Deciding to become a mother,” “The journey during pregnancy, childbirth, and the postpartum period,” and “Surviving as a mother with multiple sclerosis.” For women with MS, being a mother, pregnancy, and the postpartum period were complex and challenging issues. During this period, most women felt lonely, thought that they were contradictory and inadequately informed by healthcare professionals and that they could not get enough social support. Despite all the difficulties, being a mother was a source of motivation for them. This meta-synthesis study provides healthcare professionals with an in-depth understanding of the experiences of women with MS with pregnancy, childbirth, postpartum period, and motherhood from their perspectives.