Multiple sclerosis masquerading as a mass lesion

Giang, Daniel W.; Poduri, Kanakadurga R.; Eskin, Thomas A.; Ketonen, Leena; Friedman, Paul; Wang, D. D.; Herndon, Robert M.

doi:10.1007/bf00588163

Cited by 78 publications

(40 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rarely demyelinating disease may present as a solitary large lesion mimicking brain neoplasm. These large demyelinating lesions (LDLs) were previously named as "demyelinating pseudotumors," "tumefactive demyelinating lesions" (TDL) or "CNS IIDDs with tumefactive features" [2,3]. Literature suggests that LDLs do occur in patients already diagnosed with MS, with clinical outcome and prognosis similar to classic MS [2,4].…”

Section: Introductionmentioning

confidence: 97%

Evolution and long term outcome in patients presenting with large demyelinating lesions as their first clinical event

Wattamwar

Baheti

Kesavadas

et al. 2010

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 97%

Evolution and long term outcome in patients presenting with large demyelinating lesions as their first clinical event

Wattamwar

Baheti

Kesavadas

et al. 2010

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…In many cases, reliable differentiation of neoplastic from nonneoplastic brain masses is difficult, or even impossible, with conventional MR imaging. [1][2][3][4][5][6] In these cases, information provided by additional MR techniques may be of help. Proton MR spectroscopy ( 1 H-MR spectroscopy) is a noninvasive MR technique that provides biochemical information from tissues that has proved useful in discriminating between tumor types [7][8][9][10][11][12] as well as discriminating between tumors and pseudotumors.…”

mentioning

confidence: 99%

Proton MR Spectroscopy Improves Discrimination between Tumor and Pseudotumoral Lesion in Solid Brain Masses

Majós¹,

Aguilera²,

Alonso³

et al. 2008

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…In general, on magnetic resonance imaging (MRI) these lesions are characterized by hyperintensity on T2-weighted images, which often corresponds to hypointensity on T1-weighted images, usually less extensive. They frequently have a round shape, with regular borders, perilesional edema and mild mass effect [4,5,6,7]. Although a minimal diameter has not been defined before, a limit has been established by convention at 3 cm [8,9].…”

Section: Introductionmentioning

confidence: 99%

Pseudotumoral Forms of Multiple Sclerosis: Report of 14 Cases and Review of the Literature

et al. 2014

View full text Add to dashboard Cite

Background: The pseudotumoral form of multiple sclerosis (MS) is a rare condition with few descriptions in the literature. It supposes a diagnostic challenge especially when appearing at the onset of disease. Methods: We retrospectively describe a case series of pseudotumoral MS patients that attended our hospital from 2004, analyzing demographic, clinical and radiological variables. We classified the lesions according to the recently proposed morphologic classification (infiltrative, megacystic, Baló or ring-like) and according to the contrast enhancement pattern (nodular, complete ring, incomplete ring and diffuse). Results: Fourteen patients (11 female, 3 male), with a mean age of 35 years, were identified. All of them suffered from a relapsing-remitting form of MS. Eleven patients (78.57%) had symptomatic pseudotumoral lesions (PL), being the form of clinical presentation in the majority of those patients that were symptomatic (81.81%). Several patients presented atypical clinical manifestations such as cognitive impairment (21.42%) and epileptic seizures (14.28%). Full recovery was found in 53.84% of all symptomatic episodes. After a mean follow-up of 43 months, recurrent PL episodes were seldom observed (21.42%), the annualized relapse rate was 0.95 and the mean final Expanded Disability Status Scale score was 1.5. The majority of PLs were supratentorial, coexisted with typical demyelinating plaques and showed the ring-like morphology and the ring pattern of contrast enhancement. Three patients had more than one PL on the same scan, all of the lesions with similar morphology. Conclusions: Our findings contribute to a better characterization of pseudotumoral forms of MS. However, larger studies are required to define this atypical entity more exactly.

show abstract

Multiple sclerosis masquerading as a mass lesion

Abstract: Six patients presenting with new neurological deficits underwent magnetic resonance imaging (MRI) that displayed mass lesions leading to diagnoses of tumor or abscess. Biopsy revealed demyelinating lesions.

Cited by 78 publications

References 10 publications

Evolution and long term outcome in patients presenting with large demyelinating lesions as their first clinical event

Evolution and long term outcome in patients presenting with large demyelinating lesions as their first clinical event

Proton MR Spectroscopy Improves Discrimination between Tumor and Pseudotumoral Lesion in Solid Brain Masses

Pseudotumoral Forms of Multiple Sclerosis: Report of 14 Cases and Review of the Literature

Contact Info

Product

Resources

About