Multiple Sclerosis Presented Acute Hearing Loss and Vertigo

Sasaki, Osamu; Ootsuka, Koichi; Taguchi, Kiichiro; Kikukawa, Masato

doi:10.1159/000276609

Cited by 17 publications

(5 citation statements)

References 13 publications

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“…The most common type of hearing loss (after normal hearing) for the group of subjects with MS and for the group of control subjects without MS was sensorineural hearing loss. This is the most common type of hearing loss typically reported in articles of both individuals with and without MS. Additionally, this type of hearing loss is consistent with the disease process of MS and prior investigations have suggested that sensorineural hearing loss in individuals with MS is due to swelling and/or scarring in the lower portions of the central auditory pathways or in the cochlear nerve [24,26,28,30,[33][34][37][38] …”

Section: Discussionsupporting

confidence: 81%

“…This is consistent with Noffsinger et al [1], as well as research on the general population [3,[6][7], which suggests that most hearing losses are bilateral rather than unilateral. It does, however, contradict case-study reports of individuals with MS presenting sudden Sensorineural hearing loss [24][25][26][27][28][29][30][31][32][33][34][35][36]. In those reports, the loss was typically unilateral but returned to normal or previous HLs after a given period of time (sometime after the exacerbation in symptoms).…”

Section: Discussionmentioning

confidence: 83%

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Audiometric hearing status of individuals with and without multiple sclerosis

Lewis¹,

Lilly²,

Hutter³

et al. 2010

JRRD

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Abstract-The purpose of the present investigation was to determine whether differences exist in audiometric hearing status between individuals with and without multiple sclerosis (MS) and between individuals with relapsing-remitting MS (RRMS) and individuals with secondary progressive MS (SPMS). Forty-seven subjects with MS (26 with RRMS and 21 with SPMS) and forty-nine control subjects without MS completed both a comprehensive case-history questionnaire and a conventional hearing evaluation. Statistical analyses, accounting for the potential confounding factors of age, sex, noise exposure, and use of ototoxic medications, revealed significant differences in hearing thresholds between subjects with and without MS at select audiometric test frequencies (p < 0.05). At these audiometric test frequencies, the subjects with MS had poorer hearing thresholds. Additional analyses revealed significant differences in hearing sensitivity at select audiometric frequencies between the subjects with RRMS and the subjects with SPMS, such that those with SPMS had poorer hearing thresholds. These findings have significant clinical implications for practitioners working with patients with MS.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 83%

Audiometric hearing status of individuals with and without multiple sclerosis

Lewis¹,

Lilly²,

Hutter³

et al. 2010

JRRD

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“…In MS there is a high incidence of vestibular disturbances, and some human conditions, such as vertigo, can be caused by inflammatory responses in the brainstem and cerebellum (45)(46)(47)(48), similar to what is observed in nonclassical EAE. The factors that determine the spatial localization of these lesions are not well understood, and the nonclassical model presented in this report holds promise in defining the mechanisms underlying these phenomena.…”

Section: Discussionmentioning

confidence: 67%

IFN-γ Determines Distinct Clinical Outcomes in Autoimmune Encephalomyelitis

Wensky

Furtado²,

Marcondes³

et al. 2005

The Journal of Immunology

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Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the CNS initiated by autoreactive CD4+ T cells. EAE classically presents with a progressive ascending paralysis and is a model of multiple sclerosis that recapitulates some aspects of the disease. In this report we describe a mouse strain that spontaneously develops a severe, nonclassical form of EAE with 100% incidence. The distinct clinical phenotype is marked initially by a slight head tilt, progressing to a severe head tilt, spinning, or a rotatory motion. Classical EAE spontaneously occurs in myelin basic protein (MBP)-specific TCR transgenic RAG-1−/− mice (referred to as T/R−), whereas nonclassical EAE spontaneously occurs in T/R− IFN-γ−/− mice (T/R−γ−). Thus, the TCR recognizes the same Ag (MBP) and uses identical TCR in both cases. The cellular infiltrate in nonclassical EAE is predominantly found in the brainstem and cerebellum, with very little inflammation in the spinal cord, which is primarily affected in classical disease. Importantly, depending on the genetic makeup and priming conditions of the MBP-specific T cells, nonclassical disease can occur in the presence of an inflammatory infiltrate with eosinophilic, neutrophilic, or monocytic characteristics. Finally, we believe that nonclassical spontaneous EAE could be a useful model for the study of some characteristics of multiple sclerosis not observed in classical EAE, such as the inflammatory responses in the brainstem and cerebellum that can cause vertigo.

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“…2,4,13 In our patient no brainstem demyelinating lesion was detected, but brain MRI was performed after a month of SSNHL initiation and after intratympanic dexamethasone administration. 2,5,[7][8][9][10][11] The same BAEPs pattern is present in most of the cases with definite MS and SSNHL. 13 There has been debate on the precise site of demyelination in definite MS patients with SSNHL.…”

Section: Discussionmentioning

confidence: 99%