Multiple sclerosis-related cognitive changes: A review of cross-sectional and longitudinal studies

Amato, Maria Pia; Zipoli, Valentina; Portaccio, Emilio

doi:10.1016/j.jns.2005.08.019

Cited by 478 publications

(429 citation statements)

References 39 publications

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“…Cognitive impairment (CI) is known to be present in patients with POMS, being consistently reported in approximately one-third of patients, 3 while in the AOMS population 40%-65% of patients present CI. 4 The most affected cognitive domains in the paediatric population with MS are similar to those observed in adults, with a predominant involvement of memory, complex attention, information processing speed, executive functions and visual-spatial abilities. [3][4][5][6] Additionally, in POMS subjects, there is accumulating evidence of involvement of linguistic faculties 1,6 and lower intellectual efficiency in terms of intelligence quotient (IQ), particularly in those with younger age at MS onset.…”

Section: Introductionmentioning

confidence: 76%

Patients with paediatric-onset multiple sclerosis are at higher risk of cognitive impairment in adulthood: An Italian collaborative study

et al. 2017

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Background: Patients with paediatric-onset multiple sclerosis (POMS) could be at an increased risk for cognitive impairment (CI), given the potential harmful effects of disease activity in neurodevelopment. However, there is scarce information on their long-term cognitive outcomes. Objective: To compare the prevalence and profile of CI between adults with a history of POMS and those with classic, adult-onset multiple sclerosis (AOMS). Methods: Cognitive performance was assessed through the Brief Repeatable Battery (BRB) and the Stroop Test in consecutive patients referred to six Italian MS centres. CI was defined as impairment in ⩾2 cognitive domains. Results: In all, 119 patients with POMS and 712 with AOMS were included in this analysis. The prevalence of CI was 48.0% in AOMS, 44.5% in POMS; with similar neuropsychological profile between the two groups. However, when adjusting for current age, we found a significantly increased risk for CI (odds ratio (OR) = 1.71; p = 0.02) and for impairment in information processing speed (OR = 1.86; p < 0.01) in patients with POMS. A higher Expanded Disability Status Scale (EDSS) was also identified in POMS (p = 0.03) compared with AOMS patients. Conclusion: Patients with a history of POMS appear to be at higher risk of physical and cognitive disability than AOMS patients, after correcting for age effects, with particular involvement of information processing speed.

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Section: Introductionmentioning

confidence: 76%

Patients with paediatric-onset multiple sclerosis are at higher risk of cognitive impairment in adulthood: An Italian collaborative study

et al. 2017

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“…Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system of autoimmune origin [45]; based upon the clinical course, MS is classified in three distinct subtypes, i.e. relapsing remitting (RR), secondary progressive (SP), and primary progressive (PP).…”

Section: I) Immune-mediated Disordersmentioning

confidence: 99%

Soluble HLA-G: Are they clinically relevant?

Pistoia¹,

Morandi²,

Wang³

et al. 2007

Seminars in Cancer Biology

162

182

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HLA-G is a non-classical HLA-class Ib molecule with multiple immunoregulatory properties. Its main function in physiological conditions is to abrogate maternal NK cell activity against foetal tissue and to establish immune tolerance at maternal-foetal interface. HLA-G is expressed not only as a membrane bound molecule on the surface of cells, but also as a soluble moiety in body fluids. The major isoforms of HLA-G present in serum are soluble HLA-G1 and HLA-G5 which are generated by shedding or proteolytic cleavage of the membrane bound isoform and by secretion of a soluble isoform, respectively.Here we review the data about soluble HLA-G (sHLA-G) serum levels in different pathological conditions, including immune-mediated disorders, transplantation, and malignancies. In particular, we focus on sHLA-G expression and function in human neuroblastoma, a pediatric tumor, with special emphasis on a novel potential immuno escape mechanism utilized by NB to instruct monocytes to produce and release sHLA-G. Finally, the potential clinical relevance of sHLA-G serum levels is discussed.

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“…Similar to dysarthria, cognitive deficits are a common and prominent feature of MS. Research suggests that approximately 50% of MS patients are impaired on NP testing (Amato et al, 2006;Arnett, 2003;Benedict et al, 2006;Brass et al, 2006;Brassington & Marsh, 1998;Jonsson et al, 2006;Rao et al, 1991). As noted earlier, many of the tasks that are most sensitive to cognitive dysfunction in MS require the patient to make a rapid oral motor response.…”

Section: Introductionmentioning

confidence: 98%

Oralmotor slowing in multiple sclerosis: Relationship to neuropsychological tasks requiring an oral response

Arnett

Smith

Barwick

et al. 2008

J Inter Neuropsych Soc

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Although most neuropsychological batteries used with multiple sclerosis (MS) patients now exclude tests that require significant motor writing or manual manipulation speed, many of the most sensitive commonly used cognitive tests nonetheless require some type of rapid oral motor response. The aim of this study is to examine the extent to which primary oral motor articulation speed problems of individuals with MS contribute to performance and group differences on neuropsychological tasks requiring a rapid spoken response. Fifty MS patients and 50 healthy controls were administered the PASAT, COWAT, Animal Naming, and SDMT tests, in addition to a measure of rudimentary oral motor speed known as the maximum repetition rate of syllables and multisyllabic combinations (MRR) task. Regression analyses revealed that the amount of variance accounted for by the group (MS-Control) variable was reduced the following amounts for the tasks when the MRR was entered before the group variable: SDMT, 10% to 6%; PASAT, 4% to 2%; COWAT, 5% to 2%; Animal Naming, 11% to 7%. Our data suggest that rudimentary oral motor speed is slowed in MS patients and makes an important contribution to group differences in performance on commonly used neuropsychological tasks requiring a rapid spoken response. (JINS, 2008, 14, 454-462.)

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Multiple sclerosis-related cognitive changes: A review of cross-sectional and longitudinal studies

Cited by 478 publications

References 39 publications

Patients with paediatric-onset multiple sclerosis are at higher risk of cognitive impairment in adulthood: An Italian collaborative study

Patients with paediatric-onset multiple sclerosis are at higher risk of cognitive impairment in adulthood: An Italian collaborative study

Soluble HLA-G: Are they clinically relevant?

Oralmotor slowing in multiple sclerosis: Relationship to neuropsychological tasks requiring an oral response

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