Multiple Serotypes of Vibrio Choleræ Isolated From a Case of Cholera

Gangarosa, Eugene J.; Sanati, Azar; Saghari, H.; Feeley, John C.

doi:10.1016/s0140-6736(67)92542-1

Cited by 44 publications

(28 citation statements)

References 7 publications

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“…Conversely, specific mutations in Inaba wbeT can convert the strain to Ogawa. The ability of V. cholerae O1 to undergo serotype conversion has been documented in cholera patients and in vitro [32,33]. Serotype changes also occur during epidemics.…”

Section: Cholerae O1 Serotype Epitopesmentioning

confidence: 99%

PaxVax CVD 103-HgR single-dose live oral cholera vaccine

Levine

Chen

Kaper

et al. 2017

Expert Review of Vaccines

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Section: Cholerae O1 Serotype Epitopesmentioning

confidence: 99%

PaxVax CVD 103-HgR single-dose live oral cholera vaccine

Levine

Chen

Kaper

et al. 2017

Expert Review of Vaccines

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“…cholerae O1 strains with such a periodic shift of different serotypes or serotype conversion between the Inaba and Ogawa may be a consequence of genetic reversion which is known to take place in vitro and in vivo (Colwell et al 1995, Gangarosa et al 1967, Stroeher et al 1992.The genes responsible for O1 antigen biosynthesis have been designated wbe [previously known as rfb] (Reeves et al 1996) and are localized on a 21.6-kb SacI fragment of DNA (Fallarino et al 1997). This region is highly conserved; the only changes observed between the Ogawa and Inaba serotypes are related to a mutation in the wbeT region (Yamasaki et al 1999, Stroeher et al 1992.…”

Section: Choleramentioning

confidence: 99%

“…According to Manning et al 1994, the epidemic strains had undergone a serotype conversion, possibly because of immune pressure in the population. Gangarosa et al (1967) described that the switch in O-antigen from Ogawa to Inaba is caused by selective pressure of antiOgawa antibodies and the emergence of anti-Inaba antibodies.…”

Section: Choleramentioning

confidence: 99%

Etiology of Diarrhoea with Reference to Multiple Drug Resistant Enteric Bacterial Pathogens

Shrestha¹,

Malla

Basnyat³

1970

Nepal Journal of Science and Technology

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A total of 340 stool samples were processed and studied from both sexes including all ages of patients. Association of enteropathogens between male and female was not statistically significant. Incidence of diarrhoea (28.23%) as well as prevalence of enteropathogens (34.31%) was found highest in the age group (20-30) years. The highest prevalence of enteropathogens (44.87%) was found in August. Of the total isolated enteropathogens, Vibrio cholerae O1 was observed in 51.96% followed by Shigella (18.6%) and Salmonella (8.82%) and parasites were also detected from 20.58% samples. All isolated V. cholerae O1 were El Tor, Inaba. Among Shigella, majority of isolates were S. flexneri. Among Salmonella, S. typhi, S. typhimurium and Salmonella spp. (polyvalent A-S positive) were identified. Entamoeba histolytica, Girdia lamblia, Ascaris lumbricoides and Trichuris trichiura were isolated among parasites. All isolated (100%) V. cholerae O1 were resistant to nalidixic acid and cotrimoxazole, whereas 68%; 63%; 53%; 37% and 11% Shigella were resistant to nalidixic acid, ampicillin, cotrimoxazol, mecillinam and ciprofloxacin respectively. Similarly, 55.5%; 44.4% and 11.1% Salmonella were resistant to nalidixic acid; ampicillin and cotrimoxazole respectively. All V. cholerae strains, 10 strains of Shigella and 2 strains of Salmonella were found multi drug resistant (MDR). The clinical history of the positive cases revealed that abdominal pain, fever, vomiting, dehydration and nausea were the symptoms of enteric infection.

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“…cholerae 01 strains have been demonstrated to interconvert between the Ogawa and Inaba forms (7)(8)(9)(10)(11). However, the reciprocal nature of these conversions has been the subject of contention.…”

mentioning

confidence: 99%

Serotype conversion in Vibrio cholerae O1.

Stroeher

Karageorgos

Morona

et al. 1992

Proc. Natl. Acad. Sci. U.S.A.

179

166

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Vibrio cholerae 01 exists as two major serotypes, Inaba and Ogawa, which are associated with the 0 antigen of the lipopolysaccharide and are capable of unequal reciprocal interconversion. The 20-kilobase rJb regions encoding O-antigen biosynthesis in strains 569B (Inaba) and 017 (Ogawa) have been cloned in Escherichia coi K-12 and the nucleotide sequences have been determined. Besides several base substitutions and a small deletion in the 569B sequence relative to 017, there is a single nucleotide change resulting in a TGA stop codon within the gene for the 32-kDa RfbT protein.

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Multiple Serotypes of Vibrio Choleræ Isolated From a Case of Cholera

Cited by 44 publications

References 7 publications

PaxVax CVD 103-HgR single-dose live oral cholera vaccine

PaxVax CVD 103-HgR single-dose live oral cholera vaccine

Etiology of Diarrhoea with Reference to Multiple Drug Resistant Enteric Bacterial Pathogens

Serotype conversion in Vibrio cholerae O1.

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