Multiple‐site avascular necrosis A complication of Goodpasture's syndrome treated with plasma exchange and corticosteroids

Six patients with advanced squamous cell cancers of the head and neck, with serum IgA greater than or equal to 400 mg/dl and IgE less than or equal to 1000 IU/ml, underwent a trial of six 2-liter plasma exchanges over a 2-3-week period. Disease progressed in patients 1, 2, and 4, who died on days 44, 72, and 159. The tumor in patients 3 and 6 regressed significantly, repeatedly in patient 3 over each of four courses of apheresis. Tumor recurred in both patients after cessation of treatment, and they died at days 420 and 79. Patient 5, with inoperable disease, received full-dose radiotherapy immediately following the course of apheresis, and showed complete response in the primary lesion and a major response in the extensive lymph node metastases, dying on day 421 of apparently unrelated causes. Serum IgE in the three patients experiencing tumor regression rose paradoxically during plasmapheresis. Only patient 3 had an elevated level of soluble E-receptor suppressor factor prepheresis; the serum of patient 6 was lymphocytotoxic prepheresis but this activity decreased or disappeared during each of the exchanges studied. Controlled trials are now indicated.

show abstract

Plasma exchange in six patients with advanced cancers of the head and neck

Seder

Katz

Keggins

et al. 1985

J of Clinical Apheresis

View full text Add to dashboard Cite

show abstract

Case report 554

et al. 1989

View full text Add to dashboard Cite

Painful bone end sclerosis

Steadman

Rigby

Lloyd

et al. 1987

The American Journal of Medicine

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Multiple‐site avascular necrosis A complication of Goodpasture's syndrome treated with plasma exchange and corticosteroids

Cited by 5 publications

References 8 publications

Plasma exchange in six patients with advanced cancers of the head and neck

Plasma exchange in six patients with advanced cancers of the head and neck

Case report 554

Painful bone end sclerosis

Contact Info

Product

Resources

About