Multiple skin tumors on light-exposed areas during long-term treatment with hydroxyurea

Squamous Cell Carcinoma Accompanying Chronic Myeloid Leukemia: Case Report and Review of the Literature

“…Malign skin tumors may arise as early as 1.5-2 years after the initiation of hydroxyurea therapy. 9,23 For this reason, these lesions must be photographed on each follow-up, thus comparison may be done. Hydroxyurea therapy replacement with another drug may be offered to the hematology clinic if any suspicious squamous cell carcinoma or basal cell carcinoma lesions appear.…”

“…Best et al (1998) reported two cases with myeloproliferative diseases who developed multiple skin cancers after long term therapy with hydroxyurea which the cumulative dose was 3958 grams. 15 Papi et al (1993) reported the appearece of multiple squamous cell carcinomas and basal cell carcinomas in an old age patient with CML treated with hydroxyurea for 1.5 years with a cumulative dose of 1825 grams. 9 Esteve et al has reported an 83 year old woman recieving long term (2 years) hydroxyurea with a cumulative dose of 4745 grams for polycythemia vera, with synchrononus multiple cutaneous and oral squamous cell carcinomas.…”

“…15 Papi et al (1993) reported the appearece of multiple squamous cell carcinomas and basal cell carcinomas in an old age patient with CML treated with hydroxyurea for 1.5 years with a cumulative dose of 1825 grams. 9 Esteve et al has reported an 83 year old woman recieving long term (2 years) hydroxyurea with a cumulative dose of 4745 grams for polycythemia vera, with synchrononus multiple cutaneous and oral squamous cell carcinomas. 23 MDe Benedditis et al listed 23 available reported cases in litterature with cutaneous squamous and basal cell carcinomas and oral cancer which were affected by CML essential thrombocytopenia and polycythemia vera who recieved long term therapy with hydroxyurea mentioning their underlying diseases, ages, duration and cumulative dose of treatment with hydroxyurea.…”

“…[6][7][8] The occurence of actinic keratosis has been reported in some patients treated with long term hydroxyurea therapy for chronic myelogenous leukemia. [9][10] Our aim in this study was to present a case how we operated to excise the squamous cell cacinomas on the upper lip and dorsum of the hand and reconstruct them. At the same time, we tried to understand review and discuss the underlying reasons average time needed for the development of squamous cell carcinoma in patients recieving hydroxyurea.…”

Multiple Squamous-Cell Carcinomas of the Scalp and Chronic Myeloid Leukemia

“…There are however 2 recent cases [1][2][3] which are very similar to our patient: 2 men with CML aged 65 and 70 years, treated with 1.5 and 5.5 mg/day of hydroxyurea, respectively, for 2 and 4 years whilst in the accelerated phase, in whom actinic keratosis lesions and, later on, mul tiple squamous-cell carcinomas appeared in the light-ex posed areas, one of the patients having phototype I. The occurrence of cutaneous squamous-cell carcinomas in these patients does not appear to us to be coincidental, especially when taking into account the speed with which they devel oped, their large number, their chronological features with the CML and the fact that they appeared during or just be fore an accelerated phase of the CML, as in our patient.…”