Multiple small bowel metastasis of primary non‐small cell lung cancer

Kang, Do Kyun; Kang, Myung Koo; Heo, Woon Je; Hwang, Youn‐Ho; Nam, Kyung Han

doi:10.1002/ccr3.3821

Cited by 3 publications

(5 citation statements)

References 9 publications

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Section: Discussionmentioning

confidence: 57%

“…Small bowel metastasis has a relatively worse prognosis as it often leads to perforation [4,8]. Table 1 shows other presentations of adenocarcinoma that have a similar pathologic diagnosis to our patient's case [9][10][11][12][13][14][15][16]. Early detection, diagnosis, and treatment are crucial for improving patient outcomes in duodenal metastasis from primary lung cancer, which often goes unnoticed due to its benign clinical presentation, low incidence, and diagnostic challenges.…”

Section: Discussionmentioning

confidence: 62%

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Delayed Diagnosis of Duodenal Metastasis From Primary Lung Adenocarcinoma: A Case Report

Aldecoa,

Frame,

Satei

et al. 2023

Cureus

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The incidence of lung cancer metastasizing to the duodenum is rare, and its clinical presentation is still not fully understood due to its low frequency. It can be asymptomatic or present symptomatically in various ways. Here, we present the case of a 63-year-old female with an unusual case of duodenal metastasis from pulmonary adenocarcinoma, presenting with a new-onset seizure complicated by a fracture from a post-ictal fall. The diagnosis of anemia secondary to duodenal metastasis from lung cancer was delayed due to this sequence of events. The patient was ultimately found to have a circumferential mass in the third portion of the duodenum on esophagogastroduodenoscopy, which was found to be consistent with metastatic pulmonary adenocarcinoma on pathological examination.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 62%

Delayed Diagnosis of Duodenal Metastasis From Primary Lung Adenocarcinoma: A Case Report

Aldecoa,

Frame,

Satei

et al. 2023

Cureus

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“…Of the reported cases we found, all occurred in men (in contrast to our female patient) [ 24 - 33 ]. The most common type of NSCLC was adenocarcinoma (seven patients out of 11) [ 15 , 24 , 26 , 29 - 32 ]. Of the cases that directly identified the location of the metastases, the jejunum was a common site of disease occurrence [ 15 , 24 - 25 , 27 , 30 , 32 ], which is similar to our case.…”

Section: Discussionmentioning

confidence: 99%

“…The most common type of NSCLC was adenocarcinoma (seven patients out of 11) [ 15 , 24 , 26 , 29 - 32 ]. Of the cases that directly identified the location of the metastases, the jejunum was a common site of disease occurrence [ 15 , 24 - 25 , 27 , 30 , 32 ], which is similar to our case.…”

Section: Discussionmentioning

confidence: 99%

“…This discrepancy in prevalence between autopsy and clinical reports demonstrates how little is known regarding this type of metastatic disease and how it may be underdiagnosed. Interestingly, the prevalence of GI metastasis from NSCLC is 0.2-10% [ 15 , 16 ], whereas, in small cell lung cancer, the prevalence rate is roughly 8.0%, as determined by McNeill et al in the late 1980s [ 17 ]. In 2006, Yoshimoto et al determined the prevalence rate of GI metastasis from small cell lung cancer to be 14.9%, with 6.9% occurring in the small intestines [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Intraluminal Small Bowel Metastasis From Primary Lung Cancer

et al. 2022

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Lung cancer is the leading cause of cancer-related death worldwide, with frequent metastases to the brain, liver, adrenal glands, and bone. The incidence of intraluminal small bowel metastases of the lung is extremely rare and poorly documented within the literature. Few case studies have been published since the late 1980s and early 1990s. However, little is known about this rare form of metastasis. Small bowel metastatic disease has atypical symptoms that mimic a variety of other diseases; as a result, signs and symptoms may be overlooked until the disease has progressed to a late stage. Signs of small bowel obstruction, symptomatic anemia, abdominal pain, and peritonitis are commonly reported signs and symptoms. Various modalities can be utilized for the workup of suspected small bowel metastasis, including positron emission tomography, computed tomography, and various forms of endoscopy. The prognosis for lung cancer patients with intestinal metastases is poor, with many only surviving months to a few years after diagnosis. Therefore, it is critical to consider small bowel masses as a differential diagnosis in a patient with primary lung cancer who demonstrates clinical signs consistent with symptomatic anemia secondary to gastrointestinal (GI) bleeding, peritonitis, or small bowel obstruction. We report an unusual case of intraluminal and fungating small bowel masses in a patient who had previously undergone lung resections and chemo-immunotherapy. She was diagnosed with non-small undifferentiated carcinoma with tumor necrosis over 12 years before disease recurrence in the bilateral lungs, right adrenal gland, bone, and small bowel. The discovery of the small bowel metastases occurred while undergoing treatment for advanced-stage disease. At this time, she completed chemo-immunotherapy and remained on maintenance immunotherapy. The patient also underwent a partial right adrenalectomy and radiotherapy to the right adrenal gland. Given that she was experiencing symptomatic anemia and further workup indicated that the GI masses were causing her anemia, she underwent palliative small bowel resection of the masses. The pathology results demonstrated that the masses originated from her primary lung cancer, confirming metastatic disease to the small bowel.

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Metastatic lung adenocarcinoma presenting with small bowel obstruction

Latif,

Ang,

Holmes

et al. 2024

BMJ Case Rep

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Lung cancer is one of the most lethal solid organ malignancies. Metastasis commonly spreads to the liver, adrenal glands and bone. We report a case of a male patient who presented with an 8 week history of cramping abdominal pain and vomiting. Subsequent investigation revealed evidence of an obstructing small bowel lesion. He underwent a small bowel resection. Histopathology revealed evidence of lung adenocarcinoma as the likely primary disease. Although metastasis of lung adenocarcinoma to the small bowel is rare, early recognition may prevent potentially life-threatening sequelae including bowel perforation and peritonitis.

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Multiple small bowel metastasis of primary non‐small cell lung cancer

Abstract: Gastrointestinal metastasis could be considered in the differential diagnosis of melena in the patient with NSCLC history.

Cited by 3 publications

References 9 publications

Delayed Diagnosis of Duodenal Metastasis From Primary Lung Adenocarcinoma: A Case Report

Delayed Diagnosis of Duodenal Metastasis From Primary Lung Adenocarcinoma: A Case Report

Intraluminal Small Bowel Metastasis From Primary Lung Cancer

Metastatic lung adenocarcinoma presenting with small bowel obstruction

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