2019
DOI: 10.1155/2019/9783986
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Multiple-Strain Malaria Infection and Its Impacts on Plasmodium falciparum Resistance to Antimalarial Therapy: A Mathematical Modelling Perspective

Abstract: The emergence of parasite resistance to antimalarial drugs has contributed significantly to global human mortality and morbidity due to malaria infection. The impacts of multiple-strain malarial parasite infection have further generated a lot of scientific interest. In this paper, we demonstrate, using the epidemiological model, the effects of parasite resistance and competition between the strains on the dynamics and control of Plasmodium falciparum malaria. The analysed model has a trivial equilibrium point … Show more

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Cited by 10 publications
(6 citation statements)
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“…In addition to field evaluations and experimental laboratory studies, insight into the dynamics of parasite co-infection benefit from modelling and theoretical approaches. Modelling can assist with the interpretation of spatial/geographical mapping to identify areas of high co-infection risk, as well as determining the strength of interactions between co-infecting parasites in vivo [ 80 , 81 ] and therapeutic impact [ 82 ]. Such data will become increasingly important in future, as climate change and human activities alter parasite and vector distributions, which may increase or reduce opportunities for species to interact.…”
Section: Evolutionary Implications and Areas That Need Developmentmentioning
confidence: 99%
“…In addition to field evaluations and experimental laboratory studies, insight into the dynamics of parasite co-infection benefit from modelling and theoretical approaches. Modelling can assist with the interpretation of spatial/geographical mapping to identify areas of high co-infection risk, as well as determining the strength of interactions between co-infecting parasites in vivo [ 80 , 81 ] and therapeutic impact [ 82 ]. Such data will become increasingly important in future, as climate change and human activities alter parasite and vector distributions, which may increase or reduce opportunities for species to interact.…”
Section: Evolutionary Implications and Areas That Need Developmentmentioning
confidence: 99%
“…Importantly, parasite clearance curves in TES are less informative in African regions where most of infections consist of multiple parasite strains, 9 , 10 meaning that resistant parasites are likely to share their host with sensitive parasites, obscuring detection, particularly early during the spread of resistance. 10 , 11 Molecular surveillance of P. falciparum parasites is a powerful tool for early detection of emergence and monitoring the spread of antimalarial drug resistance for known resistance mutations and genes.…”
Section: Introductionmentioning
confidence: 99%
“…In a study by Tabo et al [34], the interaction of the malaria parasite in sexual and asexualual stages during its life cycle, i.e., a combination of hepatocyte stage, erythrocyte stage, and mosquitostage malaria parasite into one mathematical model is studied. The authors also include blood-stage treatment as a control strategy and investigate the effect of the treatment for malaria control within the host.…”
Section: Introductionmentioning
confidence: 99%
“…The findings indicated the progression of malaria and control of the disease with a treatment strategy that combines very efficient medications against malaria parasites with effective immune responses. The studies [34,36,37] are proposed the in-host dynamics of malaria infection by considering both erythrocyte stage and hepatocyte stage malaria infection. However, to the best of our knowledge, no study has considered the within-host dynamics of malaria parasites with stage-specific antimalarial drug treatment.…”
Section: Introductionmentioning
confidence: 99%