Multiple strawberry haemangiomas-side effect of rHuEPO?

Leung, Sum-Yee

doi:10.1080/080352500750043864

Cited by 17 publications

(9 citation statements)

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“…[22][23][24][25][26][27] (Table 1). In other reports of hemangiomas in twins, 26,[28][29][30][31][32][33][34][35][36][37][38] only one twin was affected ( Table 2). In five reports, 26,29,30,32,33 the twin developed only cutaneous lesions.…”

Section: Discussionmentioning

confidence: 92%

Hemangiomatosis in Two Sets of Premature Twins

2008

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We attempted to identify the association of multifocal hemangiomas, specifically hepatic hemangiomatosis, in twins. We retrospectively reviewed our database of infants with hemangiomas, identifying those twins who both had hemangiomas, and we report two cases of twins with hemangiomatosis, including hepatic hemangiomas. Of 39 sets of twins in our Hemangioma Program, both twins had hemangiomas in seven twin sets. Of these seven sets, only the two reported in this article had hemangiomatosis. There were also five sets of triplets, with one set having two siblings affected by hemangiomas. We concluded that although hemangiomas in multiple gestation infants is well known, hemangiomatosis including hepatic hemangiomatosis is unusual.

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Section: Discussionmentioning

confidence: 92%

Hemangiomatosis in Two Sets of Premature Twins

2008

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“…Recently, the role of Epo in vasoproliferative processes and its direct interaction with endothelial cells has been emphasized in human endothelial cell-line studies (3). Moreover, the proliferative effect of rHuEpo on endothelial cells has recently been observed by Leung, who reported the development of strawberry haemangiomas in a preterm neonate, multiple and very small, shortly after starting rHuEpo (4).…”

Section: Recombinant Human Erythropoietin Might Induce Strawberry Haementioning

confidence: 99%

“…We studied 56 CF patients (aged from 3 to 21 y) and 22 healthy subjects (HS) (aged from 4 to 20 y). The PUFA profiles for plasma phospholipids (2), clinical status (faecal elastase-1, faecal fat excretion and FEV 1 ), nutritional status (standardized weight and height values) and nutrition (3,4) were assessed in both CF patients and HS.…”

Section: Recombinant Human Erythropoietin Might Induce Strawberry Haementioning

confidence: 99%

Recombinant human erythropoietin might induce strawberry haemangiomas in very‐low‐birthweight preterm infants

2003

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“…The ability of rEpo to induce haemangiomas in very low birth weight preterm infants may partly be attributed to the high proliferation potential of endothelial cells in neonates. In a case report of a preterm infant, the proliferative effects of rEpo in the development of haemangiomas have been reported (Leung, 2000). The haemangiomas in this infant were multiple, shortly after starting rEpo treatment.…”

Section: Haemangiomamentioning

confidence: 99%