Multiple substance use among young males

Kapusta, Nestor D.; Plener, Paul L.; Schmid, Rainer; Thau, K.; Walter, Henriëtte; Lesch, Otto Michael

doi:10.1016/j.pbb.2006.10.007

Cited by 38 publications

(19 citation statements)

References 42 publications

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“…Correlations between past-month VSM and numerous risky behaviors (e.g., ID use, smoking, binge drinking, and Internet gambling) observed in this national Israeli adolescent sample have also been noted among adolescents in the United States and elsewhere (Johnson et al, 1995;Ramón, Ballesteros, Martinez-Arrieta, Torrecilla, & Cabrera, 2003;Schütz et al, 1994;Storr et al, 2005;Wu & Howard, 2007). Multiple psychoactive substances used concurrently may potentiate the "positive" pharmacological effects of a drug on the reward system (Kapusta et al, 2007), thus complicating diagnosis, prognosis, and treatment.…”

Section: Factors Associated With Past-month Volatile Substance Misusementioning

confidence: 60%

Volatile Substance Misuse Among Youth in Israel: Results of a National School Survey

Neumark

Bar-Hamburger

2011

Substance Use & Misuse

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Volatile substance misuse (VSM) among Israeli youth has been identified as widespread and growing. Using data from the 2009 National School Survey of 12-18 year olds (N = 7,166), this study describes VSM prevalence among Jews and Arabs, examining relationships between past-month VSM and sociodemographic, behavioral, psychological, and interpersonal characteristics. Past-month VSM, reported by 7.5% of respondents, was significantly associated with other risky behaviors including past-month illicit drug use (Adjusted odds ratios (AOR) = 5.41, 95% CI: 3.5-8.1), Internet gambling (AOR = 2.12, 95% CI: 1.5-3.1), smoking, binge drinking, and truancy. National drug policy must address VSM and develop strategies to reduce demand and supply. Potential study limitations are noted.

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Section: Factors Associated With Past-month Volatile Substance Misusementioning

confidence: 60%

Volatile Substance Misuse Among Youth in Israel: Results of a National School Survey

Neumark

Bar-Hamburger

2011

Substance Use & Misuse

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“…Several studies strongly support a general tendency to use and become dependent on multiple substances (18, 26-28). As such, we defined substance addiction phenotypically by combining dependence data across various classes of drugs.…”

Section: Methodsmentioning

confidence: 95%

Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence

et al. 2015

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Background and Aims Twin and family studies suggest that genetic influences are shared across substances of abuse. However, despite evidence of heritability, genome-wide association and candidate gene studies have indicated numerous markers of limited effects, suggesting that much of the heritability remains missing. We estimated (1) the aggregate effect of common single nucleotide polymorphisms (SNPs) on multiple indicators of comorbid drug problems that are typically employed across community and population-based samples, and (2) the genetic covariance across these measures. Participants 2596 unrelated subjects from the “Study of Addiction: Genetics and Environment” provided information on alcohol, tobacco, cocaine, cannabis, and other illicit substance dependence. Phenotypic measures included: (1) a factor score based on DSM-IV drug dependence diagnoses (DD), (2) a factor score based on problem use (PU; i.e., 1+ DSM-IV symptoms), and (3) dependence vulnerability (DV; a ratio of DSM-IV symptoms to the number of substances used). Findings Univariate and bivariate Genome-wide complex trait analyses of this selected sample indicated that common SNPs explained 25-36% of the variance across measures, with DD and DV having the largest effects [h2SNP (CI)=0.36 (0.11-0.62) and 0.33(0.07-0.58), respectively; PU = 0.25 (-0.01-0.51)]. Genetic effects were shared across the three phenotypic measures of comorbid drug problems (rSNP; rDD-PU = 0.92 (0.76-1.00), rDD-DV = 0.97 (0.87-1.00), and rPU-DV = 0.96 (0.82-1.00)). Conclusion At least 20% of the variance in the generalized vulnerability to substance dependence is attributable to common single nucleotide polymorphisms. The additive effect of common single nucleotide polymorphisms is shared across important indicators of comorbid drug problems.

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“…Tobacco use has been implicated as a gateway drug to the use of marijuana and other illicit drugs (Beenstock and Rahav, 2002;Bentler et al, 2002). Cigarette smoking is associated with the initiation (Agrawal et al, 2007;Lai et al, 2000) and the extent (Kapusta et al, 2007;Leatherdale et al, 2007) of marijuana use in young adulthood. One study demonstrated that young adults ages 18-25 are 10 times more likely to have ever used marijuana if they also have a history of smoking cigarettes (Lai et al, 2000).…”

Section: Association Between Tobacco and Marijuana Use In Young Adultmentioning

confidence: 99%

Marijuana and Tobacco Co-Use in Young Adults: Patterns and Thoughts About Use

Ramo

Delucchi

Hall

et al. 2013

J. Stud. Alcohol Drugs

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ABSTRACT. Objective:We examined the frequency and intensity of tobacco use and thoughts about abstinence among young adults in the United States as a function of their use of marijuana. We hypothesized that heavier marijuana use would be associated with heavier tobacco use and fewer attempts to quit smoking, and we explored relationships between marijuana use and ratings of intentions and thoughts related to quitting tobacco. Method: This was a cross-sectional survey consisting of online recruitment and anonymous self-report. Participants were English literate, were between the ages of 18 and 25 years, and reported past-month tobacco use. More than half (53%) had smoked marijuana in the past 30 days. Tobacco use (quantity/frequency, Heavy Smoking Index, past-year quit attempt), thoughts about tobacco use (outcome expectancies, desire, self-effi cacy, diffi culty of quitting, abstinence goal, pros and cons, stage of change), alcohol use, and other drug use were assessed. Results: Compared with those who smoked only tobacco, cousers were younger and had smoked for fewer years; had higher household income; were more likely to be male, multiethnic, and nondaily smokers; and reported greater alcohol and other drug use. The variable of days using marijuana in the past 30 days was associated with multiple measures of tobacco use intensity/frequency. Only one association was signifi cant between marijuana use and tobacco-related cognitions: Cousers had a lower likelihood of planning to quit tobacco for good (odds ratio = 0.75, 95% CI [0.58, 0.98]). Conclusions: Findings support the association between tobacco and marijuana use among young people but speak to the importance of addressing tobacco cognitions in young adult smokers regardless of level of marijuana use. (J. Stud. Alcohol Drugs, 74, 301-310, 2013)

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Multiple substance use among young males

Cited by 38 publications

References 42 publications

Volatile Substance Misuse Among Youth in Israel: Results of a National School Survey

Volatile Substance Misuse Among Youth in Israel: Results of a National School Survey

Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence

Marijuana and Tobacco Co-Use in Young Adults: Patterns and Thoughts About Use

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