Multiple surface interaction mechanisms direct the anchoring, co-aggregation and formation of dual-species biofilm between Candida albicans and Helicobacter pylori

Palencia, Sixta L.; García, Antonio Manuel Rodríguez; Palencia, Manuel

doi:10.1016/j.jare.2021.03.013

Cited by 18 publications

(7 citation statements)

References 79 publications

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“…In addition to glucans, extracellular DNA (eDNA) found in the biofilm matrix also plays a role in the S. mutans-C. albicans interaction, especially during the initial attachment and early stages (Guo et al, 2021). The interaction between C. albicans and Helicobacter pylori was also further clarified, indicating strong attachment of the bacterial cells to the surface of C. albicans via multiple mechanisms (Palencia et al, 2022), including hydrophobic bonds between non-polar peptide chains or lipids on C. albicans cell walls and membranes of H. pylori. Hydrogen bonds may increase the strength of these interactions and formation of disulfide bonds between cysteine residues of surface proteins of both microorganisms may also be involved.…”

Section: Regulation Of the Complex Interactionmentioning

confidence: 99%

Recent Advances and Opportunities in the Study of Candida albicans Polymicrobial Biofilms

Pohl

2022

Front. Cell. Infect. Microbiol.

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It is well known that the opportunistic pathogenic yeast, Candida albicans, can form polymicrobial biofilms with a variety of bacteria, both in vitro and in vivo, and that these polymicrobial biofilms can impact the course and management of disease. Although specific interactions are often described as either synergistic or antagonistic, this may be an oversimplification. Polymicrobial biofilms are complex two-way interacting communities, regulated by inter-domain (inter-kingdom) signaling and various molecular mechanisms. This review article will highlight advances over the last six years (2016-2021) regarding the unique biology of polymicrobial biofilms formed by C. albicans and bacteria, including regulation of their formation. In addition, some of the consequences of these interactions, such as the influence of co-existence on antimicrobial susceptibility and virulence, will be discussed. Since the aim of this knowledge is to inform possible alternative treatment options, recent studies on the discovery of novel anti-biofilm compounds will also be included. Throughout, an attempt will be made to identify ongoing challenges in this area.

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Section: Regulation Of the Complex Interactionmentioning

confidence: 99%

Recent Advances and Opportunities in the Study of Candida albicans Polymicrobial Biofilms

Pohl

2022

Front. Cell. Infect. Microbiol.

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“…In addition to the endosymbiotic relationship, other forms of interactions between fungal and bacterial gastric community members have been observed, including the adherence of H. pylori to Candida species and the development of polymicrobial biofilms [ 56 , 57 ]. However, it is still not clear whether the co-infection of Candida and H. pylori exacerbates the development of gastric diseases.…”

Section: Discussionmentioning

confidence: 99%

In Search for Reasons behind Helicobacter pylori Eradication Failure–Assessment of the Antibiotics Resistance Rate and Co-Existence of Helicobacter pylori with Candida Species

Bačić

Milivojević

Petković

et al. 2023

JoF

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Helicobacter pylori eradication is characterized by decreasing successful eradication rates. Although treatment failure is primarily associated with resistance to antibiotics, other unknown factors may influence the eradication outcome. This study aimed to assess the presence of the antibiotics resistance genes in H. pylori and the presence of Candida spp., which are proposed to be endosymbiotic hosts of H. pylori, in gastric biopsies of H. pylori-positive patients while simultaneously assessing their relationship. The detection and identification of Candida yeasts and the detection of mutations specific for clarithromycin and fluoroquinolones were performed by using the real-time PCR (RT-PCR) method on DNA extracted from 110 gastric biopsy samples of H. pylori-positive participants. Resistance rate to clarithromycin and fluoroquinolone was 52% and 47%, respectively. Antibiotic resistance was associated with more eradication attempts (p < 0.05). Candida species were detected in nine (8.18%) patients. Candida presence was associated with older age (p < 0.05). A high rate of antibiotic resistance was observed, while Candida presence was scarce, suggesting that endosymbiosis between H. pylori and Candida may not be a major contributing factor to the eradication failure. However, the older age favored Candida gastric mucosa colonization, which could contribute to gastric pathologies and microbiome dysbiosis.

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“…Candida albicans also forms biofilms. The fungal pathogen often co-colonizes with bacterial pathogens and contributes to biofilm-associated infections [50][51][52][53].…”

Section: Biofilm Development and Occurrencementioning

confidence: 99%

Horizontal Gene Transfer of Antibiotic Resistance Genes in Biofilms

2023

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Most bacteria attach to biotic or abiotic surfaces and are embedded in a complex matrix which is known as biofilm. Biofilm formation is especially worrisome in clinical settings as it hinders the treatment of infections with antibiotics due to the facilitated acquisition of antibiotic resistance genes (ARGs). Environmental settings are now considered as pivotal for driving biofilm formation, biofilm-mediated antibiotic resistance development and dissemination. Several studies have demonstrated that environmental biofilms can be hotspots for the dissemination of ARGs. These genes can be encoded on mobile genetic elements (MGEs) such as conjugative and mobilizable plasmids or integrative and conjugative elements (ICEs). ARGs can be rapidly transferred through horizontal gene transfer (HGT) which has been shown to occur more frequently in biofilms than in planktonic cultures. Biofilm models are promising tools to mimic natural biofilms to study the dissemination of ARGs via HGT. This review summarizes the state-of-the-art of biofilm studies and the techniques that visualize the three main HGT mechanisms in biofilms: transformation, transduction, and conjugation.

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Multiple surface interaction mechanisms direct the anchoring, co-aggregation and formation of dual-species biofilm between Candida albicans and Helicobacter pylori

Abstract: Graphical abstract

Cited by 18 publications

References 79 publications

Recent Advances and Opportunities in the Study of Candida albicans Polymicrobial Biofilms

Recent Advances and Opportunities in the Study of Candida albicans Polymicrobial Biofilms

In Search for Reasons behind Helicobacter pylori Eradication Failure–Assessment of the Antibiotics Resistance Rate and Co-Existence of Helicobacter pylori with Candida Species

Horizontal Gene Transfer of Antibiotic Resistance Genes in Biofilms

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